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Association of Inti...
Association of Intima-Media Thickness Measured at the Common Carotid Artery With Incident Carotid Plaque : Individual Participant Data Meta-Analysis of 20 Prospective Studies
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- Tschiderer, Lena (author)
- Med Univ Innsbruck, Inst Hlth Econ, Innsbruck, Austria.
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- Seekircher, Lisa (author)
- Med Univ Innsbruck, Inst Hlth Econ, Innsbruck, Austria.
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- Izzo, Raffaele (author)
- Univ Naples Federico II, Dept Adv Biomed Sci, Naples, Italy.
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- Mancusi, Costantino V. (author)
- Univ Naples Federico II, Dept Adv Biomed Sci, Naples, Italy.
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- Manzi, Maria (author)
- Univ Naples Federico II, Dept Adv Biomed Sci, Naples, Italy.,Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.
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- Baldassarre, Damiano (author)
- Univ Milan, Dept Med Biotechnol & Translat Med, Milan, Italy.;Ctr Cardiol Monzino Stituto Ricovero & Cura & Cara, Milan, Italy.
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- Amato, Mauro (author)
- Ctr Cardiol Monzino Stituto Ricovero & Cura & Cara, Milan, Italy.
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- Tremoli, Elena (author)
- Maria Cecilia Hosp, Cotignola, Ravenna, Italy.
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- Veglia, Fabrizio (author)
- Maria Cecilia Hosp, Cotignola, Ravenna, Italy.
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- Tuomainen, Tomi-Pekka (author)
- Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.
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- Kauhanen, Jussi (author)
- Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.
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- Voutilainen, Ari (author)
- Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.
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- Iglseder, Bernhard (author)
- Gemeinnutzige Salzburger Landeskliniken Betriebsge, Dept Geriatr Med, Salzburg, Austria.;Paracelsus Med Univ, Dept Geriatr Med, Salzburg, Austria.
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- Lind, Lars (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.
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- Rundek, Tatjana (author)
- Univ Miami Miller, Dept Neurol, Sch Med, Miami, FL USA.
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- Desvarieux, Moise (author)
- Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY USA.;Inst Natl Sante & Rech Med Unite Mixte Rech 1153, Ctr Rech Epidemiol & Stat Paris Sorbonne Cite, METHODS Core, Paris, France.
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- Kato, Akihiko (author)
- Hamamatsu Univ Hosp, Blood Purificat Unit, Hamamatsu, Japan.
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- de Groot, Eric (author)
- Imagelabonline & Cardiovasc, Erichem, Netherlands.;Amsterdam Univ Med Ctr, Acad Med Ctr, Dept Gastroenterol & Hepatol, Amsterdam, Netherlands.
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- Asci, Guelay (author)
- Ege Univ, Nephrol Dept, Sch Med, Bornova, Izmir, Turkiye.
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- Ok, Ercan (author)
- Ege Univ, Nephrol Dept, Sch Med, Bornova, Izmir, Turkiye.
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- Agewall, Stefan (author)
- Karolinska Institutet,Univ Oslo, Inst Clin Sci, Oslo, Norway.;Danderyd Hosp, Karolinska Inst, Dept Clin Sci, Div Cardiol, Stockholm, Sweden.
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- Beulens, Joline W. J. D. (author)
- Vrije Univ Med Ctr, Amsterdam Univ Med Ctr, Dept Epidemiol & Data Sci, Amsterdam, Netherlands.
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- Byrne, Christopher C. (author)
- Univ Southampton, Fac Med, Sch Human Dev & Hlth, Southampton, England.;Univ Hosp Southampton, Southampton Natl Inst Hlth & Care Res, Biomed Res Ctr, Southampton, England.
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- Calder, Philip C. (author)
- Univ Southampton, Fac Med, Sch Human Dev & Hlth, Southampton, England.;Univ Hosp Southampton, Southampton Natl Inst Hlth & Care Res, Biomed Res Ctr, Southampton, England.
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- Gerstein, Hertzel (author)
- McMaster Univ, Dept Med & Populat Hlth, Res Inst, Hamilton, ON, Canada.;Hamilton Gen Hosp, Hamilton, ON, Canada.
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- Gresele, Paolo (author)
- Univ Perugia, Dept Med & Surg, Div Internal & Cardiovasc Med, Perugia, Italy.
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- Klingenschmid, Gerhard (author)
- Med Univ Innsbruck, Dept Neurol, Innsbruck, Austria.
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- Nagai, Michiaki H. (author)
- Hiroshima City Asa Hosp, Dept Internal Med Gen Med & Cardiol, Hiroshima, Japan.
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- Olsen, Michael (author)
- Univ Southern Denmark, Holbaek Hosp, Dept Internal Med, Odense, Denmark.
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- Parraga, Grace S. (author)
- Western Univ, Robarts Res Inst, Dept Med Biophys, London, ON, Canada.
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- Safarova, Maya (author)
- Univ Kansas Med Ctr, Dept Cardiovasc Med, Kansas City, KS USA.;Univ Sydney, Fac Med & Hlth, Charles Perkins Ctr, Sydney, NSW, Australia.
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- Sattar, Naveed (author)
- Univ Glasgow, British Heart Fdn Glasgow Cardiovasc Res Ctr, Glasgow, Scotland.
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Skilton, Michael (author)
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- Stehouwer, Coen D. A. (author)
- Maastricht Univ Med Ctr, Cardiovasc Res Inst Maastricht, Dept Internal Med, Maastricht, Netherlands.
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- Uthoff, Heiko A. (author)
- Univ Hosp Basel, Dept Angiol, Basel, Switzerland.
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- van Agtmael, Michiel A. (author)
- Amsterdam Univ Med Ctr, Vrije Univ, Dept Internal Med, Amsterdam, Netherlands.
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- van der Heijden, Amber A. (author)
- Vrije Univ Med Ctr, Amsterdam Univ Med Ctr, Dept Gen Practice, Amsterdam, Netherlands.
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- Zozulinska-Ziolkiewicz, Dorota (author)
- Poznan Univ Med Sci, Dept Internal Med & Diabetol, Poznan, Poland.
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- Park, Hyun-Woong (author)
- Chungnam Natl Univ, Sejong Hosp, Dept Internal Med, Div Cardiol, Sejong Si, South Korea.
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- Lee, Moo-Sik (author)
- Konyang Univ, Coll Med, Dept Prevent Med, Daejeon, South Korea.;Konyang Univ Hosp, Dept Occupat & Environm Med, Daejeon, South Korea.
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- Bae, Jang-Ho (author)
- Konyang Univ Hosp, Heart Ctr, Daejeon, South Korea.
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- Beloqui, Oscar F. (author)
- Univ Clin Navarra, Dept Internal Med, Navarra, Spain.
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- Landecho, Manuel (author)
- Univ Clin Navarra, Dept Internal Med, Navarra, Spain.
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- Plichart, Matthieu (author)
- Univ Paris 05, Paris Cardiovasc Res Ctr, Paris, France.
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- Ducimetiere, Pierre (author)
- Hosp Home, Fdn St Serv, Levallois Perret, France.
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- Empana, Jean Philippe (author)
- Univ Paris 05, Paris Cardiovasc Res Ctr, Paris, France.
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- Bokemark, Lena (author)
- Univ Gothenburg, Wallenberg Lab Cardiovasc Res, Gothenburg, Sweden.
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- Bergstroem, Goeran (author)
- Univ Gothenburg, Inst Med, Sahlgrenska Acad, Dept Mol & Clin Med, Gothenburg, Sweden.
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- Schmidt, Caroline (author)
- Univ Gothenburg, Wallenberg Lab Cardiovasc Res, Gothenburg, Sweden.
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- Castelnuovo, Samuela (author)
- Aziende Socio Sanitarie Territoriali Grande Osped, Ctr Dislipidemie, Milan, Italy.
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- Calabresi, Laura D. (author)
- Univ Milan, Dept Pharmacol & Biomol Sci, Milan, Italy.;Stituto Ricovero & Cura Carattere Sci Multimed, Milan, Italy.
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- Norata, Giuseppe (author)
- Univ Milan, Dept Pharmacol & Biomol Sci, Milan, Italy.;Bassini Hosp, Soc Italiana Studio Aterosclerosi Ctr Study Athero, Cinisello Balsamo, Italy.
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Grigore, Liliana (author)
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- Catapano, Alberico (author)
- Univ Milan, Dept Pharmacol & Biomol Sci, Milan, Italy.;Stituto Ricovero & Cura Carattere Sci Multimed, Milan, Italy.
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- Zhao, Dong (author)
- Capital Med Univ, Beijing Anzhen Hosp, Dept Epidemiol, Beijing, Peoples R China.
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- Wang, Miao (author)
- Capital Med Univ, Beijing Anzhen Hosp, Dept Epidemiol, Beijing, Peoples R China.
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- Liu, Jing (author)
- Capital Med Univ, Beijing Anzhen Hosp, Dept Epidemiol, Beijing, Peoples R China.
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- Ikram, M. Arfan (author)
- Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.
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- Kavousi, Maryam L. (author)
- Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.
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- Bots, Michiel J. (author)
- Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands.
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- Sweeting, Michael W. (author)
- Univ Leicester, Dept Hlth Sci, Leicester, England.;Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England.
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- Lorenz, Matthias (author)
- Goethe Univ, Dept Neurol, Frankfurt, Germany.;Krankenhaus NW Frankfurt, Klin Neurol, Frankfurt, Germany.
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- Willeit, Peter (author)
- Med Univ Innsbruck, Inst Hlth Econ, Innsbruck, Austria.;Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England.;Med Univ Innsbruck, Anichstr 35, A-6020 Innsbruck, Austria.
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Med Univ Innsbruck, Inst Hlth Econ, Innsbruck, Austria Univ Naples Federico II, Dept Adv Biomed Sci, Naples, Italy. (creator_code:org_t)
- Ovid Technologies (Wolters Kluwer Health), 2023
- 2023
- English.
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In: Journal of the American Heart Association. - : Ovid Technologies (Wolters Kluwer Health). - 2047-9980. ; 12:12
- Related links:
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Background: The association between common carotid artery intima-media thickness (CCA-IMT) and incident carotid plaque has not been characterized fully. We therefore aimed to precisely quantify the relationship between CCA-IMT and carotid plaque development.Methods and Results: We undertook an individual participant data meta-analysis of 20 prospective studies from the Proof-ATHERO (Prospective Studies of Atherosclerosis) consortium that recorded baseline CCA-IMT and incident carotid plaque involving 21 494 individuals without a history of cardiovascular disease and without preexisting carotid plaque at baseline. Mean baseline age was 56 years (SD, 9 years), 55% were women, and mean baseline CCA-IMT was 0.71 mm (SD, 0.17 mm). Over a median follow-up of 5.9 years (5th-95th percentile, 1.9-19.0 years), 8278 individuals developed first-ever carotid plaque. We combined study-specific odds ratios (ORs) for incident carotid plaque using random-effects meta-analysis. Baseline CCA-IMT was approximately log-linearly associated with the odds of developing carotid plaque. The age-, sex-, and trial arm-adjusted OR for carotid plaque per SD higher baseline CCA-IMT was 1.40 (95% CI, 1.31-1.50; I-2=63.9%). The corresponding OR that was further adjusted for ethnicity, smoking, diabetes, body mass index, systolic blood pressure, low- and high-density lipoprotein cholesterol, and lipid-lowering and antihypertensive medication was 1.34 (95% CI, 1.24-1.45; I-2=59.4%; 14 studies; 16 297 participants; 6381 incident plaques). We observed no significant effect modification across clinically relevant subgroups. Sensitivity analysis restricted to studies defining plaque as focal thickening yielded a comparable OR (1.38 [95% CI, 1.29-1.47]; I-2=57.1%; 14 studies; 17 352 participants; 6991 incident plaques).Conclusions: Our large-scale individual participant data meta-analysis demonstrated that CCA-IMT is associated with the long-term risk of developing first-ever carotid plaque, independent of traditional cardiovascular risk factors.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- carotid intima-media thickness
- carotid plaque
- individual participant data meta-analysis
- prospective studies
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Tschiderer, Lena
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Seekircher, Lisa
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Izzo, Raffaele
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Mancusi, Costant ...
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Manzi, Maria
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Baldassarre, Dam ...
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show more...
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Amato, Mauro
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Tremoli, Elena
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Veglia, Fabrizio
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Tuomainen, Tomi- ...
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Kauhanen, Jussi
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Voutilainen, Ari
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Iglseder, Bernha ...
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Lind, Lars
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Rundek, Tatjana
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Desvarieux, Mois ...
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Kato, Akihiko
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de Groot, Eric
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Asci, Guelay
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Ok, Ercan
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Agewall, Stefan
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Beulens, Joline ...
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Byrne, Christoph ...
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Calder, Philip C ...
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Gerstein, Hertze ...
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Gresele, Paolo
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Klingenschmid, G ...
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Nagai, Michiaki ...
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Olsen, Michael
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Parraga, Grace S ...
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Safarova, Maya
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Sattar, Naveed
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Skilton, Michael
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Stehouwer, Coen ...
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Uthoff, Heiko A.
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van Agtmael, Mic ...
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van der Heijden, ...
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Zozulinska-Ziolk ...
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Park, Hyun-Woong
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Lee, Moo-Sik
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Bae, Jang-Ho
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Beloqui, Oscar F ...
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Landecho, Manuel
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Plichart, Matthi ...
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Ducimetiere, Pie ...
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Empana, Jean Phi ...
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Bokemark, Lena
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Bergstroem, Goer ...
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Schmidt, Carolin ...
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Castelnuovo, Sam ...
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Calabresi, Laura ...
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Norata, Giuseppe
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Grigore, Liliana
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Catapano, Alberi ...
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Zhao, Dong
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Wang, Miao
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Liu, Jing
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Ikram, M. Arfan
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Kavousi, Maryam ...
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Bots, Michiel J.
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Sweeting, Michae ...
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Lorenz, Matthias
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Willeit, Peter
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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Journal of the A ...
- By the university
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Uppsala University
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Karolinska Institutet