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Diarylether-Amino A...
Diarylether-Amino Acid Conjugates as New Class of Anticancer Agents
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- Thanh Le, Thanh (author)
- PetroVietnam Univ, Long Toan Ward, Fac Petr Engn, 762 Cach Mang Thang Tam St, Ba Ria City, Ba RiaVungTau P, Vietnam.
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- Huy Vo, Vinh (author)
- Ho Chi Minh City Univ Educ, Ward 4, Fac Chem, Dept Organ Chem, 280 Duong Vuong St, Ho Chi Minh City, Vietnam.
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- Thanh Huong Le, Thi (author)
- TNU Univ Sci, Tan Thinh Ward, Fac Biotechnol, Thai Nguyen City, Vietnam.;Thai Nguyen Univ, Tan Thinh Ward, Ctr Interdisciplinary Sci & Educ CISE, Thai Nguyen City, Vietnam.
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- Huy Hoang Vo, Nguyen (author)
- Ton Duc Thang Univ, Fac Pharm, Ho Chi Minh City, Vietnam.
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- Loc Le, Xuan (author)
- Vietnam Natl Univ Ho Chi Minh City, Linh Trung Ward, Sch Med, Ho Chi Minh City, Vietnam.
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- Hong Tuoi Do, Thi (author)
- Univ Med & Pharm Ho Chi Minh City, Ben Nghe Ward, Fac Pharm, Dept Pharmacol, 41 Dinh Tien Hoang St, Ho Chi Minh City, Vietnam.
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- Vu, Thien Y. (author)
- Ton Duc Thang Univ, Fac Pharm, Ho Chi Minh City, Vietnam.
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- Hung Nguyen, Phu (author)
- TNU Univ Sci, Tan Thinh Ward, Fac Biotechnol, Thai Nguyen City, Vietnam.;Thai Nguyen Univ, Tan Thinh Ward, Ctr Interdisciplinary Sci & Educ CISE, Thai Nguyen City, Vietnam.
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- Vo, Duc Duy (author)
- Uppsala universitet,Institutionen för kemi - BMC,Institutionen för cell- och molekylärbiologi,Tra Vinh Univ, Ward 5, Sch Appl Chem, 126 Nguyen Thien Thanh St, Tra Vinh, Vietnam.
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- Le, Tin Thanh (author)
- Ho Chi Minh City Univ Educ, Ward 4, Fac Chem, Dept Organ Chem, 280 Duong Vuong St, Ho Chi Minh City, Vietnam.
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PetroVietnam Univ, Long Toan Ward, Fac Petr Engn, 762 Cach Mang Thang Tam St, Ba Ria City, Ba RiaVungTau P, Vietnam Ho Chi Minh City Univ Educ, Ward 4, Fac Chem, Dept Organ Chem, 280 Duong Vuong St, Ho Chi Minh City, Vietnam. (creator_code:org_t)
- Wiley, 2023
- 2023
- English.
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In: CHEMISTRYSELECT. - : Wiley. - 2365-6549. ; 8:28
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Diarylether (DE) is a privileged structure found in both natural products and synthetic compounds including small molecule drugs. We present the synthesis of a series of 13 new DE-amino acid conjugates which were screened for cancer cells antiproliferation activity. Structure-activity relationship suggests ester and phenyl groups in DE-Phe-OEt 4 c are important for the activity. Compound 4 c inhibited strongly MCF-7 3D tumor sphere formation and have favourable calculated physical chemical properties according to Lipinski's rule of 5. Docking study suggests estrogen receptor and/ or 3a-HSD type 3 protein could be the target(s) for anticancer activity of this class of compounds.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- NATURVETENSKAP -- Kemi -- Organisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Organic Chemistry (hsv//eng)
Keyword
- anticancer
- amino acid conjugate
- amide coupling
- diaryl ether
- SNAr reaction
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Thanh Le, Thanh
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Huy Vo, Vinh
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Thanh Huong Le, ...
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Huy Hoang Vo, Ng ...
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Loc Le, Xuan
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Hong Tuoi Do, Th ...
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show more...
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Vu, Thien Y.
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Hung Nguyen, Phu
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Vo, Duc Duy
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Le, Tin Thanh
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biochemistry and ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Chemical Science ...
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and Organic Chemistr ...
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CHEMISTRYSELECT
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Uppsala University