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  • Benz, Alexander P.McMaster Univ, Populat Hlth Res Inst, 237 Barton St E, Hamilton, ON L8L 2X2, Canada.;Johannes Gutenberg Univ Mainz, Univ Med Ctr Mainz, Dept Cardiol, Langenbeckstr 1, D-55131 Mainz, Germany. (author)

Plasma angiopoietin-2 and its association with heart failure in patients with atrial fibrillation

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • Oxford University Press (OUP),2023
  • electronicrdacarrier

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  • LIBRIS-ID:oai:DiVA.org:uu-508880
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-508880URI
  • https://doi.org/10.1093/europace/euad200DOI

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  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Aims: Several biomarkers are associated with clinical outcomes in patients with atrial fibrillation (AF), but a causal relationship has not been established. This study aimed to evaluate angiopoietin-2, a novel candidate biomarker of endothelial inflammation and vascular remodelling, in patients with AF.Methods and results: Angiopoietin-2 was measured in plasma obtained from patients with AF treated with aspirin monotherapy (exploration cohort, n = 2987) or with oral anticoagulation (validation cohort, n = 13 079). Regression models were built to assess the associations between angiopoietin-2, clinical characteristics, and outcomes. In both cohorts, plasma angiopoietin-2 was independently associated with AF on the baseline electrocardiogram and persistent/permanent AF, age, history of heart failure, female sex, tobacco use/smoking, body mass index, renal dysfunction, diabetes, and N-terminal pro-B-type natriuretic peptide (NT-proBNP). Angiopoietin-2 was independently associated with subsequent hospitalization for heart failure after adjusting for age, creatinine, and clinical characteristics in the exploration cohort [c-index 0.79, 95% confidence interval (CI) 0.75-0.82; third vs. first quartile, hazard ratio (HR) 1.74, 95% CI 1.26-2.41] and in the validation cohort (c-index 0.76, 95% CI 0.74-0.78; HR 1.58, 95% CI 1.37-1.82). In both cohorts, the association persisted when also adjusting for NT-proBNP (P & LE; 0.001). In full multivariable models also adjusted for NT-proBNP, angiopoietin-2 did not show statistically significant associations with ischaemic stroke, cardiovascular and all-cause death, or major bleeding that were consistent across the two cohorts.Conclusions: In patients with AF, plasma levels of angiopoietin-2 were independently associated with subsequent hospitalization for heart failure and provided incremental prognostic value to clinical risk factors and NT-proBNP.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Hijazi, ZiadUppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi(Swepub:uu)ziahi940 (author)
  • Lindbäck, JohanUppsala universitet,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)jolin255 (author)
  • Connolly, Stuart J.McMaster Univ, Populat Hlth Res Inst, 237 Barton St E, Hamilton, ON L8L 2X2, Canada. (author)
  • Eikelboom, John W.McMaster Univ, Populat Hlth Res Inst, 237 Barton St E, Hamilton, ON L8L 2X2, Canada. (author)
  • Kastner, PeterRoche Diagnost GmbH, Penzberg, Germany. (author)
  • Ziegler, AndreRoche Diagnost GmbH, Penzberg, Germany. (author)
  • Alexander, John H.Duke Univ, Duke Clin Res Inst, Durham, NC USA. (author)
  • Granger, Christopher B.Duke Univ, Duke Clin Res Inst, Durham, NC USA. (author)
  • Lopes, Renato D.Duke Univ, Duke Clin Res Inst, Durham, NC USA. (author)
  • Oldgren, Jonas,1964-Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)jonaoldg (author)
  • Siegbahn, Agneta,1947-Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Klinisk kemi(Swepub:uu)agsie424 (author)
  • Wallentin, Lars,1943-Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)larswall (author)
  • McMaster Univ, Populat Hlth Res Inst, 237 Barton St E, Hamilton, ON L8L 2X2, Canada.;Johannes Gutenberg Univ Mainz, Univ Med Ctr Mainz, Dept Cardiol, Langenbeckstr 1, D-55131 Mainz, Germany.Uppsala kliniska forskningscentrum (UCR) (creator_code:org_t)

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  • In:Europace: Oxford University Press (OUP)25:71099-51291532-2092

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