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  • Jansen, Theodorus J. P.Radboud Univ Nijmegen, Dept Med Imaging, Med Ctr, Nijmegen, Netherlands. (author)

Monitoring beta-Cell Survival After Intrahepatic Islet Transplantation Using Dynamic Exendin PET Imaging : A Proof-of-Concept Study in Individuals With Type 1 Diabetes

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • American Diabetes Association,2023
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-509288
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-509288URI
  • https://doi.org/10.2337/db22-0884DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Intrahepatic transplantation of islets of Langerhans (ITx) is a treatment option for individuals with complicated type 1 diabetes and profoundly unstable glycemic control, but its therapeutic success is hampered by deterioration of graft function over time. To improve ITx strategies, technologies to noninvasively monitor the fate and survival of transplanted islets over time are of great potential value. We used [Ga-68]Ga-NODAGA-exendin-4 (Ga-68-exendin) positron emission tomography (PET)/computed tomography (CT) imaging to demonstrate the feasibility of quantifying b-cellmass in intrahepatic islet grafts in 13 individuals with type 1 diabetes, nine after ITx with functional islet grafts and four control patients not treated with ITx. beta-Cell function was measured by mixed-meal tolerance test. With dynamic Ga-68-exendin PET/CT images, we determined tracer accumulation in hepatic hotspots, and intrahepatic fat was assessed using MRI and spectroscopy. Quantification of hepatic hotspots showed a significantly higher uptake of Ga-68-exendin in the ITx group compared with the control group (median 0.55 [interquartile range 0.51-0.63] vs. 0.43 [0.42-0.45]). GLP-1 receptor expression was found in transplanted islets by immunohistochemistry. Intrahepatic fat was not detected in a majority of the individuals. Our study provides the first clinical evidence that radiolabeled exendin imaging can be used to monitor viable transplanted islets after intraportal ITx.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Buitinga, MijkeMaastricht Univ, Dept Nutr & Movement Sci, Maastricht, Netherlands.;Maastricht Univ, Dept Radiol & Nucl Med, Med Ctr, Maastricht, Netherlands. (author)
  • Boss, MartiRadboud Univ Nijmegen, Dept Med Imaging, Med Ctr, Nijmegen, Netherlands. (author)
  • Nijhoff, Michiel F.Leiden Univ, Internal Med, Med Ctr, Leiden, Netherlands. (author)
  • Brom, MaartenRadboud Univ Nijmegen, Dept Med Imaging, Med Ctr, Nijmegen, Netherlands. (author)
  • de Galan, Bastiaan E.Radboud Univ Nijmegen, Internal Med, Med Ctr, Nijmegen, Netherlands.;Maastricht Univ, Internal Med, Med Ctr, Maastricht, Netherlands.;Maxima Med Ctr, Internal Med, Veldhoven, Netherlands. (author)
  • van der Graaf, MarinetteRadboud Univ Nijmegen, Dept Med Imaging, Med Ctr, Nijmegen, Netherlands. (author)
  • van Koeverden, SebastiaanRadboud Univ Nijmegen, Dept Med Imaging, Med Ctr, Nijmegen, Netherlands. (author)
  • Vantyghem, Marie-ChristineCHU Lille, Endocrinol, Lille, France.;Translat Res Diabet, Lille, France. (author)
  • Beron, AmandineCHU Lille, Nucl Med, Lille, France. (author)
  • Pattou, FrancoisTranslat Res Diabet, Lille, France. (author)
  • Engelse, Marten A.Leiden Univ, Internal Med, Med Ctr, Leiden, Netherlands. (author)
  • Velikyan, Irina,1966-Uppsala universitet,Institutionen för läkemedelskemi(Swepub:uu)irinveli (author)
  • Eriksson, OlofUppsala universitet,Institutionen för läkemedelskemi(Swepub:uu)oloer586 (author)
  • de Koning, Eelco J. P.Leiden Univ, Internal Med, Med Ctr, Leiden, Netherlands. (author)
  • Gotthardt, MartinRadboud Univ Nijmegen, Dept Med Imaging, Med Ctr, Nijmegen, Netherlands. (author)
  • Radboud Univ Nijmegen, Dept Med Imaging, Med Ctr, Nijmegen, Netherlands.Maastricht Univ, Dept Nutr & Movement Sci, Maastricht, Netherlands.;Maastricht Univ, Dept Radiol & Nucl Med, Med Ctr, Maastricht, Netherlands. (creator_code:org_t)

Related titles

  • In:Diabetes: American Diabetes Association72:7, s. 898-9070012-17971939-327X

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