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Predictive biomarke...
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Slipsager, AnnaAalborg Univ Hosp, Dept Oncol, Aalborg, Denmark.;Aalborg Univ Hosp, Clin Canc Res Ctr, Aalborg, Denmark.;Aalborg Univ, Dept Clin Med, Aalborg, Denmark.;Dept Oncol, Hobrovej 18-22, DK-9000 Aalborg, Denmark.,Aalborg University Hospital
(author)
Predictive biomarkers in radioresistant rectal cancer : A systematic review
- Article/chapterEnglish2023
Publisher, publication year, extent ...
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Elsevier,2023
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-509307
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-509307URI
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https://doi.org/10.1016/j.critrevonc.2023.103991DOI
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https://lup.lub.lu.se/record/095250d0-73d2-4220-afe9-913669d23de4URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:for swepub-publicationtype
Notes
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Background and aimsThe treatment of locally advanced rectal cancer often consists of neoadjuvant chemoradiotherapy followed by surgery. However, approximately 15% of patients show no response to this neoadjuvant chemoradiotherapy. This systematic review aimed to identify biomarkers of innate radioresistant rectal cancer.MethodThrough a systematic literature search, 125 papers were included and analyzed using ROBINS-I, a Cochrane risk of bias tool for non-randomized studies of interventions. Both statistically significant and nonsignificant biomarkers were identified. Biomarkers mentioned more than once in the results or biomarkers with a low or moderate risk of bias were included as the final results.ResultsThirteen unique biomarkers, three genetic signatures, one specific pathway, and two combinations of two or four biomarkers were identified. In particular, the connection between HMGCS2, COASY, and PI3K-pathway seems promising. Future scientific research should focus on further validating these genetic resistance markers.
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Henrichsen, Sofie N.Aalborg Univ Hosp, Clin Canc Res Ctr, Aalborg, Denmark.;Aalborg Univ, Dept Clin Med, Aalborg, Denmark.,Aalborg University Hospital
(author)
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Falkmer, Ursula G.Aalborg Univ Hosp, Dept Oncol, Aalborg, Denmark.;Aalborg Univ Hosp, Clin Canc Res Ctr, Aalborg, Denmark.;Aalborg Univ, Dept Clin Med, Aalborg, Denmark.,Aalborg University Hospital
(author)
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Dybkaer, KarenAalborg Univ, Dept Clin Med, Aalborg, Denmark.;Aalborg Univ Hosp, Dept Hematol, Aalborg, Denmark.,Aalborg University Hospital
(author)
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Belting, MattiasUppsala University,Lund University,Lunds universitet,Uppsala universitet,Neuroonkologi och neurodegeneration,Lund Univ, Dept Clin Sci, Lund, Sweden,Tumörmikromiljön,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Tumor microenvironment,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments(Swepub:lu)medk-mbe
(author)
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Poulsen, Laurids Ø.Aalborg Univ Hosp, Dept Oncol, Aalborg, Denmark.;Aalborg Univ Hosp, Clin Canc Res Ctr, Aalborg, Denmark.;Aalborg Univ, Dept Clin Med, Aalborg, Denmark.,Aalborg University Hospital
(author)
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Aalborg Univ Hosp, Dept Oncol, Aalborg, Denmark.;Aalborg Univ Hosp, Clin Canc Res Ctr, Aalborg, Denmark.;Aalborg Univ, Dept Clin Med, Aalborg, Denmark.;Dept Oncol, Hobrovej 18-22, DK-9000 Aalborg, Denmark.Aalborg University Hospital
(creator_code:org_t)
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In:Critical reviews in oncology/hematology: Elsevier1861040-84281879-0461
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