Plasma levels of arginines at term pregnancy in relation to mode of onset of labor and mode of childbirth

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Akhter, Tansim,1967-Uppsala universitet,Obstetrisk och reproduktiv hälsoforskning (author)

Plasma levels of arginines at term pregnancy in relation to mode of onset of labor and mode of childbirth

Article/chapterEnglish2023

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John Wiley & Sons,2023
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LIBRIS-ID:oai:DiVA.org:uu-510533
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-510533URI
https://doi.org/10.1111/aji.13767DOI

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Language:English
Summary in:English

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PROBLEM: The exact biochemical mechanisms that initiate labor are not yet fully understood. Nitric oxide is a potent relaxant of uterine smooth muscles until labor starts, and its precursor is L-arginine. Asymmetric (ADMA) and symmetric (SDMA) dimethylarginines, are potent NO-inhibitors. However, arginines (dimethylarginines and L-arginine) are scarcely studied in relation to labor and childbirth. We aimed to investigate arginines in women with spontaneous (SLVB) and induced (ILVB) term labor with vaginal birth and in women undergoing elective caesarean section (ECS).METHOD OF STUDY: Women at gestational week 16-18 were recruited to the population-based prospective cohort study BASIC at the Uppsala University Hospital, Sweden. Plasma samples taken at start of labor were analyzed for arginines, from SLVB (n = 45), ILVB (n = 45), and ECS (n = 45), using Ultra-High Performance Liquid Chromatography. Between-group differences were assessed using Kruskal-Wallis and Mann-Whitney U-test.RESULTS: Women with SLVB and ILVB had higher levels of ADMA (p < .0001), SDMA (p < .05) and lower L-arginines (p < .01), L-arginine/ADMA (p < .0001), and L-arginine/SDMA (p < .01, respectively <.001) compared to ECS. However, ILVB had higher ADMA (p < .0001) and lower L-arginine (p < .01), L-arginine/ADMA (p < .0001), and L-arginine/SDMA (p < .01) compared to SLVB. Results are adjusted for gestational length at birth and cervical dilatation at sampling.CONCLUSION: Our novel findings of higher levels of dimethylarginines in term vaginal births compared to ECS give insights into the biochemical mechanisms of labor. These findings might also serve as a basis for further studies of arginines in complicated pregnancies and labor.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Reproduktionsmedicin och gynekologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Obstetrics, Gynaecology and Reproductive Medicine hsv//eng
arginines
dimethylarginines
mode of childbirth
mode of onset of labor
term pregnancy

Added entries (persons, corporate bodies, meetings, titles ...)

Hedeland, MikaelUppsala universitet,Analytisk kemi(Swepub:uu)mikahede (author)
Bergquist, JonasUppsala universitet,Analytisk farmaceutisk kemi(Swepub:uu)jbe25356 (author)
Ubhayasekera, KumariUppsala universitet,Analytisk farmaceutisk kemi(Swepub:uu)kumub884 (author)
Larsson, AndersUppsala universitet,Klinisk kemi(Swepub:uu)andlarss (author)
Kullinger, MeritUppsala universitet,Obstetrisk och reproduktiv hälsoforskning,Centrum för klinisk forskning, Västerås(Swepub:uu)merku451 (author)
Skalkidou, Alkistis,1977-Uppsala universitet,Obstetrisk och reproduktiv hälsoforskning(Swepub:uu)alksk607 (author)
Uppsala universitetObstetrisk och reproduktiv hälsoforskning (creator_code:org_t)

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In:American Journal of Reproductive Immunology: John Wiley & Sons90:31046-74081600-0897

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