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Met-enkephalin inhibits 5-hydroxytryptamine release from the rat ventral spinal cord via delta opioid receptors
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- Franck, Johan (author)
- Karolinska Institutet
-
- Nylander, Ingrid (author)
- Department of Clinical Neuroscience, Alcohol and Drug Dependence Research Section, Karolinska Hospital,Pharmacology
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- Rosen, Annika (author)
- Karolinska Institutet
- (creator_code:org_t)
- Elsevier BV, 1996
- 1996
- English.
- In: Neuropharmacology. - : Elsevier BV. - 0028-3908 .- 1873-7064. ; 35:6, s. 743-749
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- The effect of opioid receptor agonists and antagonists on the electrically evoked release of endogenous serotonin (5-hydroxytryptamine, 5-HT) was studied in superfused slices of the rat ventral lumbar spinal cord. Met-ENK (1 x 10(-8)M-1 x 10(-6)M) and DPDPE (1 x 10(-8)M-1 x 10(-6)M) reduced the evoked 5-Ht release in a concentration dependent fashion. DAMGO (1 x 10(-8)-1 x 10(-6)) and (-)-trans-(1S,2S)-U-50488 (1 x 10(-6)M) had no effect on the 5-HT release. The inhibitory effect of met-ENK was completely abolished by ICI-174,864, but neither by naloxonazine nor nor-binaltorphimine. Following i.c.v. treatment with 5,7-dihydroxytryptamine (5,7-DHT), the tissue concentration of 5-HT was reduced by 97%, whereas the concentration of noradrenaline was reduced by only 5%. The tissue concentration of met-ENK, as measured by radioimmunoassay, was not significantly altered. The results suggest that met-ENK is present in the rat ventral spinal cord mainly in non-serotonergic nerve terminals and exerts an inhibitory action on 5-HT release via delta opioid receptors.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Keyword
- DAMGO
- DPDPE
- 5
- 7-dihydroxytryptamine
- 5-hydroxytryptamine
- ICI-174
- 864
- met-enkephalin
- naloxonazine
- nor-binaltorphimine
- opioid receptors
- spinal cord slices (ventral)
- (-)-trans-(1S
- 2S)-U-50488
- PHARMACY
- FARMACI
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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- Franck, Johan
- Nylander, Ingrid
- Rosen, Annika
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- Uppsala University
- Karolinska Institutet
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