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Repeated ethanol ad...
Repeated ethanol administration induces short- and long-term changes in enkephalin and dynorphin tissue concentrations in rat brain
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- Lindholm, Sara (author)
- Karolinska Institutet
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- Ploj, Karolina (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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- Franck, Johan (author)
- Karolinska Institutet
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- Nylander, Ingrid (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Pharmacology
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(creator_code:org_t)
- 2000
- 2000
- English.
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In: Alcohol. - 0741-8329 .- 1873-6823. ; 22:3, s. 165-171
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Recently, we have shown that rats repeatedly treated with ethanol and/or cocaine have decreased kappa-opioid receptor mRNA levels in the mesolimbic system. The aim of the present study was to investigate the short- and long-term effects of repeated ethanol administration on opioid peptide concentrations in brain tissue of male Sprague-Dawley rats. Dynorphin B (1-13) (Dyn B) and Met-enkephalinArg(6)Phe(7) (MEAP), endogenous ligands to kappa- and delta-opioid receptors, respectively, were measured using radioimmunoassays. The rats were given either ethanol [intraperitoneal (ip), twice daily, 2 g/kg bw/dose] or saline for 13 consecutive days. Thirty minutes after the last ethanol dose on Day 13, the Dyn B tissue concentration was significantly decreased in the cingulate cortex. The MEAP tissue concentration was decreased in the hippocampus 5 days after the last ethanol injection as compared to saline-treated controls. Furthermore, the Dyn B and the MEAP concentrations were increased in the periaqueductal grey area (PAG) at this time point. Of particular interest were the significant increases in Dyn B tissue concentrations found in the nucleus accumbens (NAcc) at 30 min and at 21 days after the last ethanol dose. The results suggest that repeated ethanol administration induces both short- and long-term changes in the tissue concentrations of opioids in certain brain regions associated with motivation and reward.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Keyword
- opioids
- nucleus accumbens
- dynorphin B
- ethanol
- Met-enkephalinArg(6)Phe(7)
- PHARMACY
- FARMACI
Publication and Content Type
- ref (subject category)
- art (subject category)
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