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Alphitol, a phenoli...
Alphitol, a phenolic substance from Alphitonia zizyphoides which inhibits prostaglandin biosynthesis in vitro
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- Andersson Dunstan, Christina (author)
- Uppsala universitet,Avdelningen för farmakognosi
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- Liu, Boling (author)
- Uppsala universitet,Avdelningen för farmakognosi
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- Welch, Christopher J (author)
- Uppsala universitet,Avdelningen för organisk farmaceutisk kemi
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- Perera, Premila (author)
- Uppsala universitet,Avdelningen för farmakognosi
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- Bohlin, Lars (author)
- Uppsala universitet,Avdelningen för farmakognosi
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(creator_code:org_t)
- 1998
- 1998
- English.
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In: Phytochemistry. - 0031-9422 .- 1873-3700. ; 48:3, s. 495-497
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- The new phenolic compound, 3,5-dihydroxy-4-methoxy phenethyl alcohol, named alphitol, and betulinic acid were isolated from the bark of Alphitonia zizyphoides. The chemical structure of alphitol was determined by mass spectrometry in combination with one and two dimensional NMR, including HMBC. Both compounds inhibited prostaglandin biosynthesis in vitro, alphitol with an IC50 value of 0.66 mM, which is of the same magnitude as acetyl salicylic acid.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Keyword
- Alphitonia zizyphoides
- Rhamnaceae
- prostaglandin biosynthesis
- phenyl ethanoid
- alphitol
- 3.5-dihydroxy-4-methoxy phenethyl alcohol
- betulinic acid
- PHARMACY
- FARMACI
Publication and Content Type
- ref (subject category)
- art (subject category)
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