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Efficacy of Dapagli...
Efficacy of Dapagliflozin in Heart Failure with Reduced Ejection Fraction According to Body Mass Index.
- Article/chapterEnglish2021
Publisher, publication year, extent ...
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2021-07-29
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Wiley,2021
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-512634
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-512634URI
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https://doi.org/10.1002/ejhf.2308DOI
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https://gup.ub.gu.se/publication/306172URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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AIMS: In heart failure with reduced ejection fraction (HFrEF), there is an ’obesity paradox’, where survival is better in patients with a higher body mass index (BMI) and weight loss is associated with worse outcomes. We examined the effect of a sodium-glucose co-transporter 2 inhibitor according to baseline BMI in the Dapagliflozin And Prevention of Adverse- outcomes in Heart Failure trial (DAPA-HF). METHODS AND RESULTS: Body mass index was examined using standard categories, i.e. underweight ($<$18.5 kg/m(2) ); normal weight (18.5-24.9 kg/m(2) ); overweight (25.0-29.9 kg/m(2) ); obesity class I (30.0-34.9 kg/m(2) ); obesity class II (35.0-39.9 kg/m(2) ); and obesity class III ($>$/=40 kg/m(2) ). The primary outcome in DAPA-HF was the composite of worsening heart failure or cardiovascular death. Overall, 1348 patients (28.4%) were under/normal- weight, 1722 (36.3%) overweight, 1013 (21.4%) obesity class I and 659 (13.9%) obesity class II/III. The unadjusted hazard ratio (95% confidence interval) for the primary outcome with obesity class 1, the lowest risk group, as reference was: under/normal-weight 1.41 (1.16-1.71), overweight 1.18 (0.97-1.42), obesity class II/III 1.37 (1.10-1.72). Patients with class I obesity were also at lowest risk of death. The effect of dapagliflozin on the primary outcome and other outcomes did not vary by baseline BMI, e.g. hazard ratio for primary outcome: under/normal-weight 0.74 (0.58-0.94), overweight 0.81 (0.65-1.02), obesity class I 0.68 (0.50-0.92), obesity class II/III 0.71 (0.51-1.00) (P-value for interaction = 0.79). The mean decrease in weight at 8 months with dapagliflozin was 0.9 (0.7-1.1) kg (P $<$ 0.001). CONCLUSION: We confirmed an ’obesity survival paradox’ in HFrEF. We showed that dapagliflozin was beneficial across the wide range of BMI studied. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov NCT03036124.
Subject headings and genre
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Jhund, Pardeep S.
(author)
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Docherty, Kieran F.
(author)
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Belohlavek, Jan
(author)
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Chiang, Chern-En
(author)
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Diez, Mirta
(author)
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Drozdz, Jaroslaw
(author)
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Dukat, Andrej
(author)
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Howlett, Jonathan
(author)
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Ljungman, Charlotta,1977Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xljcha
(author)
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Petrie, Mark C.
(author)
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Schou, Morten
(author)
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Inzucchi, Silvio E.
(author)
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Kober, Lars
(author)
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Kosiborod, Mikhail N.
(author)
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Martinez, Felipe A.
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Ponikowski, Piotr
(author)
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Sabatine, Marc S.
(author)
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Solomon, Scott D.
(author)
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Bengtsson, Olof
(author)
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Langkilde, Anna Maria
(author)
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Lindholm, Daniel
(author)
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Sjöstrand, Mikaela,1964
(author)
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McMurray, John J. V.
(author)
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Adamsson, Lisa
(author)
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Göteborgs universitetInstitutionen för medicin, avdelningen för molekylär och klinisk medicin
(creator_code:org_t)
Related titles
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In:European journal of heart failure: Wiley23:10, s. 1662-16721388-98421879-0844
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Adamson, Carly
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Jhund, Pardeep S ...
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Docherty, Kieran ...
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Belohlavek, Jan
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Chiang, Chern-En
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Diez, Mirta
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Drozdz, Jaroslaw
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Dukat, Andrej
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Howlett, Jonatha ...
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Ljungman, Charlo ...
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Petrie, Mark C.
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Schou, Morten
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Inzucchi, Silvio ...
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Kober, Lars
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Kosiborod, Mikha ...
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Martinez, Felipe ...
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Ponikowski, Piot ...
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Sabatine, Marc S ...
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Solomon, Scott D ...
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Bengtsson, Olof
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Langkilde, Anna ...
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Lindholm, Daniel
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Sjöstrand, Mikae ...
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McMurray, John J ...
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Adamsson, Lisa
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Cardiac and Card ...
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European journal ...
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Uppsala University
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University of Gothenburg