Search: onr:"swepub:oai:DiVA.org:uu-512651" >
Effects of Dapaglif...
Effects of Dapagliflozin in Heart Failure with Reduced Ejection Fraction and Chronic Obstructive Pulmonary Disease : An Analysis of DAPA-HF.
-
Dewan, Pooja (author)
-
Docherty, Kieran F. (author)
-
Bengtsson, Olof (author)
-
show more...
-
de Boer, Rudolf A. (author)
-
Desai, Akshay S. (author)
-
Drozdz, Jaroslaw (author)
-
Hawkins, Nathaniel M. (author)
-
Inzucchi, Silvio E. (author)
-
Kitakaze, Masafumi (author)
-
Kober, Lars (author)
-
Kosiborod, Mikail N. (author)
-
Langkilde, Anna Maria (author)
-
Lindholm, Daniel (author)
-
Martinez, Felipe A. (author)
-
Merkely, Bela (author)
-
Petrie, Mark C. (author)
-
Ponikowski, Piotr (author)
-
Sabatine, Marc S. (author)
-
Schou, Morten (author)
-
Sjostrand, Mikaela (author)
-
Solomon, Scott D. (author)
-
Verma, Subodh (author)
-
Jhund, Pardeep S. (author)
-
McMurray, John J. V. (author)
-
show less...
- 2021-01-18
- 2021
- English.
-
In: European journal of heart failure. - : Wiley. - 1388-9842 .- 1879-0844. ; 23:4, s. 632-643
- Related links:
-
https://onlinelibrar...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- AIMS: Chronic obstructive pulmonary disease (COPD) is an important comorbidity in heart failure (HF) with reduced ejection fraction (HFrEF), associated with worse outcomes and often suboptimal treatment because of under-prescription of beta-blockers. Consequently, additional effective therapies are especially relevant in patients with COPD. The aim of this study was to examine outcomes related to COPD in a post hoc analysis of the Dapagliflozin And Prevention of Adverse-outcomes in Heart Failure (DAPA-HF) trial. METHODS AND RESULTS: We examined whether the effects of dapagliflozin in DAPA-HF were modified by COPD status. The primary outcome was the composite of an episode of worsening HF or cardiovascular death. Overall, 585 (12.3%) of the 4744 patients randomized had a history of COPD. Patients with COPD were more likely to be older men with a history of smoking, worse renal function, and higher baseline N-terminal pro B-type natriuretic peptide, and less likely to be treated with a beta-blocker or mineralocorticoid receptor antagonist. The incidence of the primary outcome was higher in patients with COPD than in those without [18.9 (95% confidence interval 16.0-22.2) vs. 13.0 (12.1-14.0) per 100 person-years; hazard ratio (HR) for COPD vs. no COPD 1.44 (1.21-1.72); P $<$ 0.001]. The effect of dapagliflozin, compared with placebo, on the primary outcome, was consistent in patients with [HR 0.67 (95% confidence interval 0.48-0.93)] and without COPD [0.76 (0.65-0.87); interaction P-value 0.47]. CONCLUSIONS: In DAPA-HF, one in eight patients with HFrEF had concomitant COPD. Participants with COPD had a higher risk of the primary outcome. The benefit of dapagliflozin on all pre-specified outcomes was consistent in patients with and without COPD. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov ID NCT03036124.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- *Heart Failure/complications/drug therapy/epidemiology
- *Pulmonary Disease
- Chronic Obstructive/complications/drug therapy/epidemiology
- Aged
- Benzhydryl Compounds
- Chronic obstructive pulmonary disease
- Dapagliflozin
- Glucosides/therapeutic use
- Heart failure
- Humans
- Male
- Stroke Volume
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Dewan, Pooja
-
Docherty, Kieran ...
-
Bengtsson, Olof
-
de Boer, Rudolf ...
-
Desai, Akshay S.
-
Drozdz, Jaroslaw
-
show more...
-
Hawkins, Nathani ...
-
Inzucchi, Silvio ...
-
Kitakaze, Masafu ...
-
Kober, Lars
-
Kosiborod, Mikai ...
-
Langkilde, Anna ...
-
Lindholm, Daniel
-
Martinez, Felipe ...
-
Merkely, Bela
-
Petrie, Mark C.
-
Ponikowski, Piot ...
-
Sabatine, Marc S ...
-
Schou, Morten
-
Sjostrand, Mikae ...
-
Solomon, Scott D ...
-
Verma, Subodh
-
Jhund, Pardeep S ...
-
McMurray, John J ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cardiac and Card ...
- Articles in the publication
-
European journal ...
- By the university
-
Uppsala University