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First cyclotide fro...
First cyclotide from Hybanthus (Violaceae)
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Broussalis, Adriana M. (author)
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- Göransson, Ulf (author)
- Uppsala universitet,Avdelningen för farmakognosi
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Coussio, Jorge D. (author)
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Ferraro, Graciela (author)
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Martino, Virginia (author)
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- Claeson, Per (author)
- Uppsala universitet,Avdelningen för farmakognosi
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(creator_code:org_t)
- Elsevier, 2001
- 2001
- English.
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In: Phytochemistry. - : Elsevier. - 0031-9422 .- 1873-3700. ; 58:1, s. 47-51
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
Close
- Hypa A, a novel macrocyclic polypeptide containing 30 amino acid residues, has been isolated from the n-butanol extract of the Argentine plant Hybanthus parviflorus. The sequence, cyclo-(SCVYIPCTITALLGCSCKNKVCYNGIPCAE), was determined by automated Edman degradation, quantitative amino acid analysis and nanospray MS/MS2. Three intramolecular disulfide bridges stabilize the cyclic peptide backbone of hypa A. Using these structural features to classify the peptide as a cyclotide, we extended the distribution of that substance class to a new genus, and now propose a uniform nomenclature for cyclotides.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Keyword
- Hybanthus parviflorus (Mutis ex L. F.) Baill.; Violaceae; Violetilla; Isolation; Primary structure; Cyclotides; Macrocyclic polypeptides; Hypa A; LCQ
- Pharmacognosy
- Farmakognosi
Publication and Content Type
- ref (subject category)
- art (subject category)
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