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The Combination of ...
The Combination of Quantitative Proteomics and Systems Genetics Analysis Reveals that PTN Is Associated with Sleep-Loss-Induced Cognitive Impairment
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- Zhou, Yutong (författare)
- Binzhou Med Univ, Shandong Technol Innovat Ctr Mol Targeting & Intel, Yantai 264003, Shandong, Peoples R China.
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- Li, Hui (författare)
- Binzhou Med Univ, Shandong Technol Innovat Ctr Mol Targeting & Intel, Yantai 264003, Shandong, Peoples R China.
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- Liu, Xiaoya (författare)
- Binzhou Med Univ, Shandong Technol Innovat Ctr Mol Targeting & Intel, Yantai 264003, Shandong, Peoples R China.
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- Chi, Xiaodong (författare)
- Binzhou Med Univ, Shandong Technol Innovat Ctr Mol Targeting & Intel, Yantai 264003, Shandong, Peoples R China.
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- Gu, Zhaoxi (författare)
- Binzhou Med Univ, Shandong Technol Innovat Ctr Mol Targeting & Intel, Yantai 264003, Shandong, Peoples R China.
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- Cui, Binsen (författare)
- Binzhou Med Univ, Shandong Technol Innovat Ctr Mol Targeting & Intel, Yantai 264003, Shandong, Peoples R China.
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- Bergquist, Jonas (författare)
- Uppsala universitet,Analytisk kemi,Science for Life Laboratory, SciLifeLab,Binzhou Med Univ, Shandong Technol Innovat Ctr Mol Targeting & Intel, Yantai 264003, Shandong, Peoples R China. Uppsala University
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- Wang, Binsheng (författare)
- Binzhou Med Univ, Shandong Technol Innovat Ctr Mol Targeting & Intel, Yantai 264003, Shandong, Peoples R China.
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- Tian, Geng (författare)
- Binzhou Med Univ, Shandong Technol Innovat Ctr Mol Targeting & Intel, Yantai 264003, Shandong, Peoples R China.
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- Yang, Chunhua (författare)
- Binzhou Med Univ, Shandong Technol Innovat Ctr Mol Targeting & Intel, Yantai 264003, Shandong, Peoples R China.
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- Xu, Fuyi (författare)
- Binzhou Med Univ, Shandong Technol Innovat Ctr Mol Targeting & Intel, Yantai 264003, Shandong, Peoples R China.
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- Mi, Jia (författare)
- Binzhou Med Univ, Shandong Technol Innovat Ctr Mol Targeting & Intel, Yantai 264003, Shandong, Peoples R China.
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Binzhou Med Univ, Shandong Technol Innovat Ctr Mol Targeting & Intel, Yantai 264003, Shandong, Peoples R China Analytisk kemi (creator_code:org_t)
- American Chemical Society (ACS), 2023
- 2023
- Engelska.
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Ingår i: Journal of Proteome Research. - : American Chemical Society (ACS). - 1535-3893 .- 1535-3907. ; 22:9, s. 2936-2949
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Sleep loss is associated with cognitive dysfunction. However, the detailed mechanisms remain unclear. In this study, we established a para-chlorophenylalanine (PCPA)-induced insomniac mouse model with impaired cognitive function. Mass-spectrometry-based proteomics showed that the expression of 164 proteins was significantly altered in the hippocampus of the PCPA mice. To identify critical regulators among the potential markers, a transcriptome-wide association screening was performed in the BXD mice panel. Among the candidates, the expression of pleiotrophin (Ptn) was significantly associated with cognitive functions, indicating that Ptn-mediates sleep-loss-induced cognitive impairment. Gene co-expression analysis further revealed the potential mechanism by which Ptn mediates insomnia-induced cognitive impairment via the MAPK signaling pathway; that is, the decreased secretion of Ptn induced by insomnia leads to reduced binding to Ptprz1 on the postsynaptic membrane with the activation of the MAPK pathway via Fos and Nr4a1, further leading to the apoptosis of neurons. In addition, Ptn is genetically trans-regulated in the mouse hippocampus and implicated in neurodegenerative diseases in human genome-wide association studies. Our study provides a novel biomarker for insomnia-induced cognitive impairment and a new strategy for seeking neurological biomarkers by the integration of proteomics and systems genetics.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- quantitative proteomics
- systems genetics
- sleep loss
- pleiotrophin
- cognitive impairment
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Zhou, Yutong
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Li, Hui
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Liu, Xiaoya
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Chi, Xiaodong
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Gu, Zhaoxi
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Cui, Binsen
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visa fler...
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Bergquist, Jonas
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Wang, Binsheng
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Tian, Geng
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Yang, Chunhua
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Xu, Fuyi
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Mi, Jia
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
- Artiklar i publikationen
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Journal of Prote ...
- Av lärosätet
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Uppsala universitet