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Anti-inflammatory a...
Anti-inflammatory activity of dichloromethane extract of Heterotheca inuloides in vivo and in vitro
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- Segura, Laura (author)
- Uppsala universitet,Avdelningen för farmakognosi
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Freixa, Blanca (author)
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- Ringbom, Therese (author)
- Uppsala universitet,Avdelningen för farmakognosi
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Vila, Roser (author)
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- Perera, Premila (author)
- Uppsala universitet,Avdelningen för farmakognosi
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Adzet, Tomás (author)
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- Bohlin, Lars (author)
- Uppsala universitet,Avdelningen för farmakognosi
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Cañigueral, Salvador (author)
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(creator_code:org_t)
- Georg Thieme Verlag KG, 2000
- 2000
- English.
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In: Planta Medica. - : Georg Thieme Verlag KG. - 0032-0943 .- 1439-0221. ; 66:6, s. 553-555
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- The dichloromethane extract from the dried flowers of Heterotheca inuloides Cass. was investigated on several pharmacological models of inflammation in vivo and in vitro. It showed anti-inflammatory activity on the croton oil-induced oedema test in mouse ear, at 1 mg/ear. The compound isolated from this extract, 7-hydroxy-3,4-dihydrocadalin, showed anti-inflammatory effect on the same experimental model (ED50 of 0.9 mumol/ear), as well as on COX-1 and COX-2 catalysed prostaglandin biosynthesis assays, with IC50 values of 22 microM and 526 microM, respectively. No effect was observed on carrageenan-induced oedema and on fMLP/PAF-induced exocytosis of human neutrophils. The COX-1 inhibitory effect showed by 7-hydroxy-3,4-dihydrocadalin might be related to the anti-inflammatory activity on the topical oedema induced by croton oil.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Keyword
- Pharmacognosy
- Farmakognosi
Publication and Content Type
- ref (subject category)
- art (subject category)
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