Importance of CD23 for collagen-induced arthritis: delayed onset and reduced severity in CD23-deficient mice

Importance of CD23 for collagen-induced arthritis : delayed onset and reduced severity in CD23-deficient mice

Kleinau, Sandra (author): Uppsala universitet,Institutionen för genetik och patologi

Martinsson, Pernilla (author): Uppsala universitet,Hematologi och immunologi

Gustavsson, Susanne (author)

Heyman, Birgitta (author): Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi

(creator_code:org_t)

1999
1999
English.
In: Journal of Immunology. - 0022-1767 .- 1550-6606. ; 162:7, s. 4266-4270

Abstract Subject headings

Increased expression of the low affinity receptor for IgE, FcepsilonRII/CD23 has been observed in rheumatoid arthritis. In view of this, we have investigated the expression and influence of CD23 in collagen-induced arthritis (CIA), an animal model for rheumatoid arthritis. CD23+ cells were analyzed in lymph nodes of DBA/1 mice immunized with bovine collagen type II (BCII) in CFA or with CFA only. The percentage of CD23+ lymph node cells was increased in both BCII/CFA- and CFA-immunized mice at 1, 3, and 7 wk after immunization compared with unimmunized mice, indicating a role for the adjuvant to trigger general inflammation and CD23 expression. To investigate the functional role of CD23 in CIA, CD23-deficient mice on the DBA/1 genetic background were studied. After immunization with BCII/CFA, these mice developed CIA with delayed onset and reduced severity compared with wild-type mice. These findings suggest that an increased number of CD23+ cells is part of an inflammatory response and that CD23 expression is of pathogenic importance in the arthritic process.

By the author/editor: Kleinau, Sandra; Martinsson, Pern ...; Gustavsson, Susa ...; Heyman, Birgitta

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