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Hallberg, IdaUppsala universitet,Reproduktionsbiologi
(author)
Associations between lifestyle factors and levels of per- and polyfluoroalkyl substances (PFASs), phthalates and parabens in follicular fluid in women undergoing fertility treatment
- Article/chapterEnglish2023
Publisher, publication year, extent ...
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Springer Nature,2023
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-514758
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-514758URI
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https://doi.org/10.1038/s41370-023-00579-1DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:153840657URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:du-46634URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Background: Concerns have been raised whether exposure to endocrine-disrupting chemicals (EDCs) can alter reproductive functions and play a role in the aetiology of infertility in women. With increasing evidence of adverse effects, information on factors associated with exposure is necessary to form firm recommendations aiming at reducing exposure.Objective: Our aim was to identify associations between lifestyle factors including the home environment, use of personal care products (PCP), and dietary habits and concentrations of EDCs in ovarian follicular fluid.Methods: April-June 2016, 185 women undergoing ovum pick-up for in vitro fertilisation in Sweden were recruited. Correlation analyses were performed between self-reported lifestyle factors and concentration of EDCs analysed in follicular fluid. Habits related to cleaning, PCPs, and diet were assessed together with concentration of six per- and polyfluoroalkyl substances (PFASs) [PFHxS, PFOA, PFOS, PFNA, PFDA and PFUnDA], methyl paraben and eight phthalate metabolites [MECPP, MEHPP, MEOHP, MEHP, cxMinCH, cxMiNP, ohMiNP, MEP, MOHiBP]. Spearman's partial correlations were adjusted for age, parity and BMI.Results: Significant associations were discovered between multiple lifestyle factors and concentrations of EDCs in ovarian follicular fluid. After correcting p values for multiple testing, frequent use of perfume was associated with MEP (correlation rho = 0.41 (confidence interval 0.21-0.47), p < 0.001); hens' egg consumption was positively associated with PFOS (rho = 0.30 (0.15-0.43), p = 0.007) and PFUnDA (rho = 0.27 (0.12-0.40), p = 0.036). White fish consumption was positively associated with PFUnDA (rho = 0.34 (0.20-0.47), p < 0.001) and PFDA (rho = 0.27 (0.13-0.41), p = 0.028). More correlations were discovered when considering the raw uncorrected p values. Altogether, our results suggest that multiple lifestyle variables affect chemical contamination of follicular fluid.Impact statement: This study shows how lifestyle factors correlate with the level of contamination in the ovary by both persistent and semi-persistent chemicals in women of reproductive age. Subsequently, these data can be used to form recommendations regarding lifestyle to mitigate possible negative health outcomes and fertility problems associated with chemical exposure, and to inform chemical policy decision making. Our study can also help form the basis for the design of larger observational and intervention studies to examine possible effects of lifestyle changes on exposure levels, and to unravel the complex interactions between biological factors, lifestyle and chemical exposures in more detail.
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Duque Björvang, RichelleUppsala universitet,Institutionen för kvinnors och barns hälsa(Swepub:uu)ricdu778
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Hadziosmanovic, NerminUppsala universitet,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)nerha973
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Koekkoekk, JaccoVrije Univ Amsterdam, Amsterdam Inst Life & Environm, Environm & Hlth, NL-1081 HV Amsterdam, Netherlands.
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Pikki, AnneCarl von Linnekliniken, SE-75183 Uppsala, Sweden.
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van Duursen, MajorieUniv Utrecht, Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Univ Weg 100, NL-3584 CG Utrecht, Netherlands.
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Lenters, VirissaVrije Univ Amsterdam, Amsterdam Inst Life & Environm, Environm & Hlth, NL-1081 HV Amsterdam, Netherlands.;Univ Utrecht, Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Univ Weg 100, NL-3584 CG Utrecht, Netherlands.
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Sjunnesson, YlvaSwedish Univ Agr Sci, Dept Clin Sci, SE-75007 Uppsala, Sweden.
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Holte, JanUppsala universitet,Reproduktionsbiologi,Carl von Linnekliniken, SE-75183 Uppsala, Sweden.(Swepub:uu)janho845
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Berglund, Lars,Docent,1955-Högskolan Dalarna,Uppsala universitet,Klinisk geriatrik,Dalarna Univ, Sch Hlth & Welf, S-79131 Falun, Sweden.,Medicinsk vetenskap,Department of Public Health and Caring Sciences, Geriatrics, Uppsala University(Swepub:du)labr
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Persson, SaraSwedish Univ Agr Sci, Dept Clin Sci, SE-75007 Uppsala, Sweden.
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Olovsson, Matts,1958-Uppsala universitet,Reproduktionsbiologi,Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Obstet & Gynecol, SE-14186 Stockholm, Sweden.(Swepub:uu)mattolov
(author)
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Damdimopoulou, PauliinaKarolinska Institutet,Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Karolinska Univ, Dept Reprod Med, Dept Med, Hosp Huddinge, SE-14186 Stockholm, Sweden.
(author)
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Uppsala universitetReproduktionsbiologi
(creator_code:org_t)
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In:Journal of Exposure Science and Environmental Epidemiology: Springer Nature33, s. 699-7091559-06311559-064X
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