onr:"swepub:oai:DiVA.org:uu-514762"
Search: onr:"swepub:oai:DiVA.org:uu-514762" > Helicobacter pylori...
- 1 of 1
- Previous record
- Next record
- To hitlist
Helicobacter pylori and Pro-Inflammatory Protein Biomarkers in Myocardial Infarction with and without Obstructive Coronary Artery Disease
-
- Warme, Jonatan (author)
- Karolinska Inst, Sodersjukhuset, Dept Clin Sci & Educ, SE-11883 Stockholm, Sweden.;Soder Sjukhuset, Dept Cardiol, SE-11883 Stockholm, Sweden.
-
- Sundqvist, Martin O. (author)
- Karolinska Inst, Sodersjukhuset, Dept Clin Sci & Educ, SE-11883 Stockholm, Sweden.;Soder Sjukhuset, Dept Cardiol, SE-11883 Stockholm, Sweden.
-
- Hjort, Marcus (author)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Institutionen för medicinska vetenskaper
- show more...
- show less...
- Karolinska Inst, Sodersjukhuset, Dept Clin Sci & Educ, SE-11883 Stockholm, Sweden;Soder Sjukhuset, Dept Cardiol, SE-11883 Stockholm, Sweden. Uppsala kliniska forskningscentrum (UCR) (creator_code:org_t)
- MDPI AG, 2023
- 2023
- English.
- In: International Journal of Molecular Sciences. - : MDPI AG. - 1661-6596 .- 1422-0067. ; 44
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Myocardial infarction (MI) with obstructive coronary artery disease (MI-CAD) and MI in the absence of obstructive coronary artery disease (MINOCA) affect different populations and may have separate pathophysiological mechanisms, with greater inflammatory activity in MINOCA compared to MI-CAD. Helicobacter pylori (Hp) can cause systemic inflammation and has been associated with cardiovascular disease (CVD). We aimed to investigate whether Hp infection is associated with concentrations of protein biomarkers of inflammation and CVD. In a case-control study, patients with MINOCA (n = 99) in Sweden were included, complemented by matched subjects with MI-CAD (n = 99) and controls (n = 100). Protein biomarkers were measured with a proximity extension assay in plasma samples collected 3 months after MI. The seroprevalence of Hp and cytotoxin-associated gene A (CagA) was determined using ELISA. The associations between protein levels and Hp status were studied with linear regression. The prevalence of Hp was 20.2%, 19.2%, and 16.0% for MINOCA, MI-CAD, and controls, respectively (p = 0.73). Seven proteins were associated with Hp in an adjusted model: tissue plasminogen activator (tPA), interleukin-6 (IL-6), myeloperoxidase (MPO), TNF-related activation-induced cytokine (TRANCE), pappalysin-1 (PAPPA), soluble urokinase plasminogen activator receptor (suPAR), and P-selectin glycoprotein ligand 1 (PSGL-1). Hp infection was present in one in five patients with MI, irrespective of the presence of obstructive CAD. Inflammatory proteins were elevated in Hp-positive subjects, thus not ruling out that Hp may promote an inflammatory response and potentially contribute to the development of CVD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- myocardial infarction
- coronary artery disease
- MINOCA
- Helicobacter pylori
- inflammation
- biomarkers
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- International Journal of Molecular Sciences (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Warme, Jonatan
- Sundqvist, Marti ...
- Hjort, Marcus
- Agewall, Stefan
- Collste, Olov
- Ekenback, Christ ...
- show more...
- Frick, Mats
- Henareh, Loghman
- Hofman-Bang, Cla ...
- Spaak, Jonas
- Sorensson, Peder
- Y-Hassan, Shams
- Svensson, Per
- Lindahl, Bertil, ...
- Hofmann, Robin
- Tornvall, Per
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Cardiac and Card ...
- Articles in the publication
- International Jo ...
- EUROPEAN HEART J ...
- By the university
- Uppsala University
- Karolinska Institutet
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
