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Stabilized and Cont...
Stabilized and Controlled Release of Radicals within Copper Formate-Based Nanozymes for Biosensing
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- Zhou, Yue (author)
- Wuhan Univ Technol, State Key Lab Adv Technol Mat Synth & Proc, Wuhan 430070, Peoples R China.;Wuhan Univ Technol, Sch Chem Chem Engn & Life Sci, Wuhan 430070, Peoples R China.
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- Chen, Xiaohua (author)
- Southern Med Univ, Nanfang Hosp, Dept Lab Med, Guangzhou 51015, Peoples R China.
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- Zhan, Shaoqi (author)
- Uppsala universitet,Biokemi
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- Wang, Qiang (author)
- Chinese Acad Sci, Innovat Acad Precis Measurement Sci & Technol, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China.
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- Deng, Feng (author)
- Chinese Acad Sci, Innovat Acad Precis Measurement Sci & Technol, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China.
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- Wu, Qingzhi (author)
- Wuhan Univ Technol, State Key Lab Adv Technol Mat Synth & Proc, Wuhan 430070, Peoples R China.;Wuhan Univ Technol, Sch Chem Chem Engn & Life Sci, Wuhan 430070, Peoples R China.
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- Peng, Jian (author)
- Wuhan Univ Technol, State Key Lab Adv Technol Mat Synth & Proc, Wuhan 430070, Peoples R China.;Wuhan Univ Technol, Sch Chem Chem Engn & Life Sci, Wuhan 430070, Peoples R China.
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Wuhan Univ Technol, State Key Lab Adv Technol Mat Synth & Proc, Wuhan 430070, Peoples R China;Wuhan Univ Technol, Sch Chem Chem Engn & Life Sci, Wuhan 430070, Peoples R China. Southern Med Univ, Nanfang Hosp, Dept Lab Med, Guangzhou 51015, Peoples R China. (creator_code:org_t)
- American Chemical Society (ACS), 2023
- 2023
- English.
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In: ACS Applied Materials and Interfaces. - : American Chemical Society (ACS). - 1944-8244 .- 1944-8252. ; 15:37, s. 43431-43440
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Abstract
Subject headings
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- Fenton-like radical processes are widely utilized to explain catalytic mechanisms of peroxidase-like nanozymes, which exhibit remarkable catalytic activity, cost-effectiveness, and stability. However, there is still a need for a comprehensive understanding of the formation, stabilization, and transformation of such radicals. Herein, a copper formate-based nanozyme (Cuf-TMB) was fabricated via a pre-catalytic strategy under ambient conditions. The as-prepared nanozyme shows comparable catalytic activity (K-m, 1.02 x 10(-5) mM(-1); K-cat, 3.09 x 10(-2) s(-1)) and kinetics to those of natural peroxidase toward H2O2 decomposition. This is attributed to the feasible oxidation by *OH species via the *O intermediate, as indicated by density functional theory calculations. The key .OH radicals were detected to be stable for over 52 days and can be released in a controlled manner during the catalytic process via in situ electron spin-resonance spectroscopy measurements. Based on the understanding, an ultrasensitive biosensing platform was constructed for the sensitive monitoring of biochemical indicators in clinic settings.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Keyword
- Cuf-TMB nanozymes
- (OH)-O-. radicals
- peroxidase-likeactivity
- radical stability
- biosensors
Publication and Content Type
- ref (subject category)
- art (subject category)
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