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An idiosyncratic zo...
An idiosyncratic zonated stroma encapsulates desmoplastic liver metastases and originates from injured liver
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- Moro, Carlos Fernandez (author)
- Karolinska Institutet
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- Geyer, Natalie (author)
- Karolinska Institutet
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- Harrizi, Sara (author)
- Karolinska Inst, Dept Biosci & Nutr, S-14183 Huddinge, Sweden.
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- Hamidi, Yousra (author)
- Karolinska Inst, Dept Biosci & Nutr, S-14183 Huddinge, Sweden.
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- Söderqvist, Sara (author)
- Karolinska Inst, Dept Biosci & Nutr, S-14183 Huddinge, Sweden.
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- Kuznyecov, Danyil (author)
- Skane Univ Hosp, Dept Clin Genet Pathol & Mol Diagnost, Med Serv, S-22185 Lund, Sweden.
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- Tidholm Qvist, Evelina (author)
- Karolinska Univ Hosp, Dept Clin Pathol & Canc Diagnost, S-14186 Stockholm, Sweden.
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- Salmonson Schaad, Media (author)
- Karolinska Inst, Dept Biosci & Nutr, S-14183 Huddinge, Sweden.
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- Hermann, Laura (author)
- Karolinska Inst, Dept Biosci & Nutr, S-14183 Huddinge, Sweden.
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- Lindberg, Amanda (author)
- Uppsala universitet,Cancerimmunterapi
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- Heuchel, Rainer L. (author)
- Karolinska Institutet
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- Martin-Bernabe, Alfonso (author)
- Karolinska Inst, Dept Oncol Pathol, S-17176 Solna, Sweden.
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- Dhanjal, Soniya (author)
- Karolinska Inst, SciLifeLab, CRISPR Funct Genom, S-17165 Solna, Sweden.;Karolinska Inst, Dept Med Biochem & Biophys, S-17165 Solna, Sweden.
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- Navis, Anna C. (author)
- Karolinska Institutet
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- Villard, Christina (author)
- Karolinska Institutet
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- del Valle, Andrea C. (author)
- Karolinska Institutet
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- Bozoky, Lorand (author)
- Karolinska Inst, Dept Biosci & Nutr, S-14183 Huddinge, Sweden.
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- Sparrelid, Ernesto (author)
- Karolinska Institutet
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- Dirix, Luc (author)
- GZA Hosp, Translat Canc Res Unit, Antwerp, Belgium.;Univ Antwerp, Antwerp, Belgium.
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- Strell, Carina (author)
- Uppsala universitet,Cancerimmunterapi,Univ Bergen, Ctr Canc Biomarkers CCBIO, Dept Clin Med, 1222222, N-5020 Bergen, Norway.
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- Östman, Arne (author)
- Karolinska Institutet
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- Schmierer, Bernhard (author)
- Karolinska Inst, SciLifeLab, CRISPR Funct Genom, S-17165 Solna, Sweden.
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- Vermeulen, Peter B. (author)
- GZA Hosp, Translat Canc Res Unit, Antwerp, Belgium.;Univ Antwerp, Antwerp, Belgium.
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- Engstrand, Jennie (author)
- Karolinska Institutet
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- Bozoky, Bela (author)
- Karolinska Univ Hosp, Dept Clin Pathol & Canc Diagnost, S-14186 Stockholm, Sweden.
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- Gerling, Marco (author)
- Karolinska Institutet
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Karolinska Institutet Karolinska Inst, Dept Biosci & Nutr, S-14183 Huddinge, Sweden (creator_code:org_t)
- Springer Nature, 2023
- 2023
- English.
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In: Nature Communications. - : Springer Nature. - 2041-1723. ; 14
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https://uu.diva-port... (primary) (Raw object)
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Abstract
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- A perimetastatic capsule is a strong positive prognostic factor in liver metastases, but its origin remains unclear. Here, we systematically quantify the capsule's extent and cellular composition in 263 patients with colorectal cancer liver metastases to investigate its clinical significance and origin. We show that survival improves proportionally with increasing encapsulation and decreasing tumor-hepatocyte contact. Immunostaining reveals the gradual zonation of the capsule, transitioning from benign-like NGFR(high) stroma at the liver edge to FAP(high) stroma towards the tumor. Encapsulation correlates with decreased tumor viability and preoperative chemotherapy. In mice, chemotherapy and tumor cell ablation induce capsule formation. Our results suggest that encapsulation develops where tumor invasion into the liver plates stalls, representing a reparative process rather than tumor-induced desmoplasia. We propose a model of metastases growth, where the efficient tumor colonization of the liver parenchyma and a reparative liver injury reaction are opposing determinants of metastasis aggressiveness.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Moro, Carlos Fer ...
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Geyer, Natalie
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Harrizi, Sara
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Hamidi, Yousra
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Söderqvist, Sara
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Kuznyecov, Danyi ...
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show more...
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Tidholm Qvist, E ...
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Salmonson Schaad ...
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Hermann, Laura
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Lindberg, Amanda
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Heuchel, Rainer ...
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Martin-Bernabe, ...
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Dhanjal, Soniya
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Navis, Anna C.
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Villard, Christi ...
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del Valle, Andre ...
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Bozoky, Lorand
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Sparrelid, Ernes ...
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Dirix, Luc
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Strell, Carina
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Östman, Arne
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Schmierer, Bernh ...
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Vermeulen, Peter ...
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Engstrand, Jenni ...
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Bozoky, Bela
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Gerling, Marco
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Nature Communica ...
- By the university
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Uppsala University
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Karolinska Institutet