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Urinary phosphate i...
Urinary phosphate is associated with cardiovascular disease incidence.
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Donat-Vargas, Carolina (author)
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Guallar-Castillon, Pilar (author)
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Nyström, Jenny (author)
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- Larsson, Susanna C. (author)
- Karolinska Institutet,Uppsala universitet,Medicinsk epidemiologi,Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
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- Kippler, Maria (author)
- Karolinska Institutet
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- Vahter, Marie (author)
- Karolinska Institutet
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Faxén-Irving, Gerd (author)
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- Michaëlsson, Karl (author)
- Uppsala universitet,Medicinsk epidemiologi
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- Wolk, Alicja (author)
- Uppsala universitet,Medicinsk epidemiologi,Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
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Stenvinkel, Peter (author)
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- Åkesson, Agneta (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2023
- 2023
- English.
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In: Journal of Internal Medicine. - 0954-6820 .- 1365-2796. ; 294:3, s. 358-369
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
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- INTRODUCTION: Elevated phosphate (P) in urine may reflect a high intake of inorganic P salts from food additives. Elevated P in plasma is linked to vascular dysfunction and calcification.OBJECTIVE: To explore associations between P in urine as well as in plasma and questionnaire-estimated P intake, and incidence of cardiovascular disease (CVD).METHODS: We used the Swedish Mammography Cohort-Clinical, a population-based cohort study. At baseline (2004-2009), P was measured in urine and plasma in 1625 women. Dietary P was estimated via a food-frequency questionnaire. Incident CVD was ascertained via register-linkage. Associations were assessed using Cox proportional hazards regression.RESULTS: After a median follow-up of 9.4 years, 164 composite CVD cases occurred (63 myocardial infarctions [MIs] and 101 strokes). Median P (percentiles 5-95) in urine and plasma were 2.4 (1.40-3.79) mmol/mmol creatinine and 1.13 (0.92-1.36) mmol/L, respectively, whereas dietary P intake was 1510 (1148-1918) mg/day. No correlations were observed between urinary and plasma P (r = -0.07) or dietary P (r = 0.10). Urinary P was associated with composite CVD and MI. The hazard ratio of CVD comparing extreme tertiles was 1.57 (95% confidence interval 1.05, 2.35; P trend 0.037)-independently of sodium excretion, the estimated glomerular filtration rate, both P and calcium in plasma, and diuretic use. Association with CVD for plasma P was 1.41 (0.96, 2.07; P trend 0.077).CONCLUSION: Higher level of urinary P, likely reflecting a high consumption of highly processed foods, was linked to CVD. Further investigation is needed to evaluate the potential cardiovascular toxicity associated with excessive intake of P beyond nutritional requirements.
Keyword
- cardiovascular disease incidence
- dietary phosphate intake
- phosphate-based additives
- plasma phosphate
- ultra-processed food
- urinary phosphate
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Donat-Vargas, Ca ...
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Guallar-Castillo ...
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Nyström, Jenny
-
Larsson, Susanna ...
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Kippler, Maria
-
Vahter, Marie
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show more...
-
Faxén-Irving, Ge ...
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Michaëlsson, Kar ...
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Wolk, Alicja
-
Stenvinkel, Pete ...
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Åkesson, Agneta
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show less...
- Articles in the publication
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Journal of Inter ...
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Uppsala University
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Karolinska Institutet