onr:"swepub:oai:DiVA.org:uu-518092"
Search: onr:"swepub:oai:DiVA.org:uu-518092" > Increased OCT3 Expr...
- 1 of 1
- Previous record
- Next record
- To hitlist
Increased OCT3 Expression in Adipose Tissue With Aging : Implications for Catecholamine and Lipid Turnover and Insulin Resistance in Women
-
- Ahmed, Fozia (author)
- Uppsala universitet,Klinisk diabetologi och metabolism
-
- Vranic, Milica (author)
- Uppsala universitet,Klinisk diabetologi och metabolism
-
- Hetty, Susanne, PhD, 1979- (author)
- Uppsala universitet,Klinisk diabetologi och metabolism
- show more...
- show less...
- (creator_code:org_t)
- Oxford University Press, 2023
- 2023
- English.
- In: Endocrinology. - : Oxford University Press. - 0013-7227 .- 1945-7170. ; 165:1
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Background Catecholamine-stimulated lipolysis is reduced with aging, which may promote adiposity and insulin resistance. Organic cation transporter 3 (OCT3), which is inhibited by estradiol (E2), mediates catecholamine transport into adipocytes for degradation, thus decreasing lipolysis. In this study, we investigated the association of OCT3 mRNA levels in subcutaneous adipose tissue (SAT) with aging and markers of insulin resistance in women.Methods SAT biopsies were obtained from 66 women with (19) or without (47) type 2 diabetes (age 22-76 years, 20.0-40.1 kg/m2). OCT3 mRNA and protein levels were measured for group comparisons and correlation analysis. SAT was incubated with E2 and OCT3 mRNA levels were measured. Associations between OCT3 single nucleotide polymorphisms (SNPs) and diabetes-associated traits were assessed.Results OCT3 mRNA and protein levels in SAT increased with aging. SAT from postmenopausal women had higher levels of OCT3 than premenopausal women, and there was a dose-dependent reduction in OCT3 mRNA levels in SAT treated with E2. OCT3 mRNA levels were negatively associated with markers of insulin resistance, and ex vivo lipolysis. OCT3 SNPs were associated with BMI, waist to hip ratio, and circulating lipids (eg, triglycerides).Conclusion OCT3 mRNA and protein levels in SAT increased with aging, and mRNA levels were negatively associated with markers of insulin resistance. E2 incubation downregulated OCT3 mRNA levels, which may explain lower OCT3 mRNA in premenopausal vs postmenopausal women. High OCT3 protein levels in adipose tissue may result in increased catecholamine degradation, and this can contribute to the reduction in lipolysis observed in women with aging.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- OCT3
- adipose tissue
- estradiol
- aging
- T2D
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- Endocrinology (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Ahmed, Fozia
- Vranic, Milica
- Hetty, Susanne, ...
- Mathioudaki, Arg ...
- Patsoukaki, Vagi ...
- Fanni, Giovanni
- show more...
- Pereira, Maria J ...
- Eriksson, Jan
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Endocrinology an ...
- Articles in the publication
- Endocrinology
- By the university
- Uppsala University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
