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Structure of a ribonucleotide reductase R2 protein radical

Lebrette, Hugo, 1986- (author)
Stockholm University,Stockholms universitet,Institutionen för biokemi och biofysik,Université Toulouse III, France,Stockholm Univ, Dept Biochem & Biophys, Arrhenius Labs Nat Sci, Stockholm, Sweden.;Univ Toulouse III, CNRS, Ctr Biol Integrat, Lab Microbiol & Genet Mol, Toulouse, France.
Srinivas, Vivek, 1988- (author)
Stockholm University,Stockholms universitet,Institutionen för biokemi och biofysik,Stockholm Univ, Dept Biochem & Biophys, Arrhenius Labs Nat Sci, Stockholm, Sweden.
John, Juliane, 1987- (author)
Stockholm University,Stockholms universitet,Institutionen för biokemi och biofysik,Stockholm Univ, Dept Biochem & Biophys, Arrhenius Labs Nat Sci, Stockholm, Sweden.
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Aurelius, Oskar, 1987- (author)
Stockholm University,Lunds universitet,Stockholms universitet,Institutionen för biokemi och biofysik,Lund University, Lund, Sweden,Stockholm Univ, Dept Biochem & Biophys, Arrhenius Labs Nat Sci, Stockholm, Sweden.;Lund Univ, MAX Lab 4, Lund, Sweden.,MAX IV-laboratoriet,MAX IV Laboratory
Kumar, Rohit, 1985- (author)
Stockholm University,Stockholms universitet,Institutionen för biokemi och biofysik,Stockholm Univ, Dept Biochem & Biophys, Arrhenius Labs Nat Sci, Stockholm, Sweden.
Lundin, Daniel, 1965- (author)
Stockholm University,Stockholms universitet,Institutionen för biokemi och biofysik,Stockholm Univ, Dept Biochem & Biophys, Arrhenius Labs Nat Sci, Stockholm, Sweden.
Brewster, Aaron S. (author)
Lawrence Berkeley Natl Lab, Mol Biophys & Integrated Bioimaging Div, Berkeley, CA 94720 USA.,Lawrence Berkeley National Laboratory
Bhowmick, Asmit (author)
Lawrence Berkeley Natl Lab, Mol Biophys & Integrated Bioimaging Div, Berkeley, CA 94720 USA.,Lawrence Berkeley National Laboratory
Sirohiwal, Abhishek, 1993- (author)
Stockholm University,Stockholms universitet,Institutionen för biokemi och biofysik,Stockholm Univ, Dept Biochem & Biophys, Arrhenius Labs Nat Sci, Stockholm, Sweden.
Kim, In-Sik (author)
Lawrence Berkeley Natl Lab, Mol Biophys & Integrated Bioimaging Div, Berkeley, CA 94720 USA.,Lawrence Berkeley National Laboratory
Gul, Sheraz (author)
Lawrence Berkeley Natl Lab, Mol Biophys & Integrated Bioimaging Div, Berkeley, CA 94720 USA.,Lawrence Berkeley National Laboratory
Pham, Cindy (author)
Lawrence Berkeley Natl Lab, Mol Biophys & Integrated Bioimaging Div, Berkeley, CA 94720 USA.,Lawrence Berkeley National Laboratory
Sutherlin, Kyle D. (author)
Lawrence Berkeley Natl Lab, Mol Biophys & Integrated Bioimaging Div, Berkeley, CA 94720 USA.,Lawrence Berkeley National Laboratory
Simon, Philipp (author)
Lawrence Berkeley Natl Lab, Mol Biophys & Integrated Bioimaging Div, Berkeley, CA 94720 USA.,Lawrence Berkeley National Laboratory
Butryn, Agata (author)
Diamond Light Source Ltd, Harwell Sci & Innovat Campus, Didcot, Oxon, England.;Res Complex Harwell, Harwell Sci & Innovat Campus, Didcot, Oxon, England.;Francis Crick Inst, Macromol Machines Lab, London, England.
Aller, Pierre (author)
Diamond Light Source Ltd, Harwell Sci & Innovat Campus, Didcot, Oxon, England.;Res Complex Harwell, Harwell Sci & Innovat Campus, Didcot, Oxon, England.
Orville, Allen M. (author)
Diamond Light Source Ltd, Harwell Sci & Innovat Campus, Didcot, Oxon, England.;Res Complex Harwell, Harwell Sci & Innovat Campus, Didcot, Oxon, England.
Fuller, Franklin D. (author)
SLAC Natl Accelerator Lab, LCLS, Menlo Pk, CA USA.,Stanford Linear Accelerator Center (SLAC)
Alonso-Mori, Roberto (author)
SLAC Natl Accelerator Lab, LCLS, Menlo Pk, CA USA.,Stanford Linear Accelerator Center (SLAC)
Batyuk, Alexander (author)
SLAC Natl Accelerator Lab, LCLS, Menlo Pk, CA USA.,Stanford Linear Accelerator Center (SLAC)
Sauter, Nicholas K. (author)
Lawrence Berkeley Natl Lab, Mol Biophys & Integrated Bioimaging Div, Berkeley, CA 94720 USA.,Lawrence Berkeley National Laboratory
Yachandra, Vittal K. (author)
Lawrence Berkeley Natl Lab, Mol Biophys & Integrated Bioimaging Div, Berkeley, CA 94720 USA.,Lawrence Berkeley National Laboratory
Yano, Junko (author)
Lawrence Berkeley Natl Lab, Mol Biophys & Integrated Bioimaging Div, Berkeley, CA 94720 USA.,Lawrence Berkeley National Laboratory
Kaila, Ville R. I., 1983- (author)
Stockholm University,Stockholms universitet,Institutionen för biokemi och biofysik,Stockholm Univ, Dept Biochem & Biophys, Arrhenius Labs Nat Sci, Stockholm, Sweden.
Sjöberg, Britt-Marie, 1944- (author)
Stockholm University,Stockholms universitet,Institutionen för biokemi och biofysik,Stockholm Univ, Dept Biochem & Biophys, Arrhenius Labs Nat Sci, Stockholm, Sweden.
Kern, Jan (author)
Lawrence Berkeley Natl Lab, Mol Biophys & Integrated Bioimaging Div, Berkeley, CA 94720 USA.,Lawrence Berkeley National Laboratory
Roos, Katarina (author)
Uppsala University,Uppsala universitet,Beräkningsbiologi och bioinformatik,Sprint Biosci, Huddinge, Sweden.
Högbom, Martin, 1974- (author)
Stockholm University,Stockholms universitet,Institutionen för biokemi och biofysik,Stockholm Univ, Dept Biochem & Biophys, Arrhenius Labs Nat Sci, Stockholm, Sweden.
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 (creator_code:org_t)
American Association for the Advancement of Science (AAAS), 2023
2023
English.
In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 382:6666, s. 109-113
Related links:
http://dx.doi.org/10...
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https://urn.kb.se/re...
https://doi.org/10.1...
https://urn.kb.se/re...
https://lup.lub.lu.s...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Aerobic ribonucleotide reductases (RNRs) initiate synthesis of DNA building blocks by generating a free radical within the R2 subunit; the radical is subsequently shuttled to the catalytic R1 subunit through proton-coupled electron transfer (PCET). We present a high-resolution room temperature structure of the class Ie R2 protein radical captured by x-ray free electron laser serial femtosecond crystallography. The structure reveals conformational reorganization to shield the radical and connect it to the translocation path, with structural changes propagating to the surface where the protein interacts with the catalytic R1 subunit. Restructuring of the hydrogen bond network, including a notably short O-O interaction of 2.41 angstroms, likely tunes and gates the radical during PCET. These structural results help explain radical handling and mobilization in RNR and have general implications for radical transfer in proteins.

Subject headings

NATURVETENSKAP  -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
NATURVETENSKAP  -- Kemi -- Fysikalisk kemi (hsv//swe)
NATURAL SCIENCES  -- Chemical Sciences -- Physical Chemistry (hsv//eng)
NATURVETENSKAP  -- Biologi -- Strukturbiologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Structural Biology (hsv//eng)

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