Sökning: onr:"swepub:oai:DiVA.org:uu-519647" > Synthesis of Substi...
Fältnamn | Indikatorer | Metadata |
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000 | 03481naa a2200505 4500 | |
001 | oai:DiVA.org:uu-519647 | |
003 | SwePub | |
008 | 240112s2023 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:152626107 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5196472 URI |
024 | 7 | a https://doi.org/10.1002/ejoc.2023002912 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1526261072 URI |
040 | a (SwePub)uud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Odell, Luke R.u Uppsala universitet,Institutionen för läkemedelskemi4 aut0 (Swepub:uu)lucod220 |
245 | 1 0 | a Synthesis of Substituted Indazole Acetic Acids by N-N Bond Forming Reactions |
264 | 1 | b Wiley-Blackwell,c 2023 |
338 | a electronic2 rdacarrier | |
520 | a Herein, we report on the discovery and development of novel cascade N-N bond forming reactions for the synthesis of rare indazole acetic acid scaffolds. This approach allows for convenient synthesis of three distinct indazole acetic acid derivatives (unsubstituted, hydroxy, and alkoxy) by heating 3-amino-3-(2-nitroaryl)propanoic acids with an appropriate nucleophile/solvent under basic conditions. The reaction tolerates a range of functional groups and electronic effects and, in total, 23 novel indazole acetic acids were synthesized and characterized. This work offers a valuable strategy for the synthesis of useful scaffolds for drug discovery programs. | |
650 | 7 | a NATURVETENSKAPx Kemix Organisk kemi0 (SwePub)104052 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Chemical Sciencesx Organic Chemistry0 (SwePub)104052 hsv//eng |
653 | a annulation | |
653 | a cyclization | |
653 | a Michael addition | |
653 | a nitrogen heterocycles | |
653 | a synthetic methods | |
700 | 1 | a Skillinghaug, Bobou Uppsala universitet,Institutionen för läkemedelskemi4 aut0 (Swepub:uu)bobsk501 |
700 | 1 | a Matt, Christofu Uppsala universitet,Preparativ läkemedelskemi4 aut0 (Swepub:uu)chrma538 |
700 | 1 | a Wu, Pengu Uppsala universitet,Institutionen för läkemedelskemi4 aut |
700 | 1 | a Koolmeister, Tobiasu Karolinska Inst, Sci Life Lab, Dept Oncol Pathol, S-17176 Stockholm, Sweden.4 aut |
700 | 1 | a Desroses, Matthieuu Karolinska Inst, Sci Life Lab, Dept Oncol Pathol, S-17176 Stockholm, Sweden.4 aut |
700 | 1 | a Llona-Minguez, Sabinu Karolinska Inst, Sci Life Lab, Dept Oncol Pathol, S-17176 Stockholm, Sweden.4 aut |
700 | 1 | a Wallner, Olovu Karolinska Institutet,Karolinska Inst, Sci Life Lab, Dept Oncol Pathol, S-17176 Stockholm, Sweden.4 aut |
700 | 1 | a Helleday, Thomasu Karolinska Inst, Sci Life Lab, Dept Oncol Pathol, S-17176 Stockholm, Sweden.4 aut |
700 | 1 | a Scobie, Martinu Karolinska Inst, Sci Life Lab, Dept Oncol Pathol, S-17176 Stockholm, Sweden.4 aut |
710 | 2 | a Uppsala universitetb Institutionen för läkemedelskemi4 org |
773 | 0 | t European Journal of Organic Chemistryd : Wiley-Blackwellg 26:29q 26:29x 1434-193Xx 1099-0690 |
856 | 4 | u https://doi.org/10.1002/ejoc.202300291y Fulltext |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1827054/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-519647 |
856 | 4 8 | u https://doi.org/10.1002/ejoc.202300291 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:152626107 |
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