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Eosinophil-derived neurotoxin levels in early childhood and association with preschool asthma - A prospective observational study

Färdig, Martin (author)
Lie, Anine (author)
Borres, Magnus P., 1956- (author)
Uppsala universitet,Pediatrisk inflammations- och metabolismforskning samt barnhälsa
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Ekenkrantz, Tina (author)
Granum, Berit (author)
Haugen, Guttorm (author)
Jonassen, Christine M (author)
Movérare, Robert (author)
Uppsala universitet,Lungmedicin och allergologi,Lung- allergi- och sömnforskning
Rehbinder, Eva Maria (author)
Skjerven, Håvard O (author)
Cathrine, Anne (author)
Vettukattil, Riyas (author)
Lødrup Carlsen, Karin C (author)
Söderhäll, Cilla (author)
Karolinska Institutet
Nordlund, Björn (author)
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 (creator_code:org_t)
John Wiley & Sons, 2023
2023
English.
In: Clinical and Experimental Allergy. - : John Wiley & Sons. - 0954-7894 .- 1365-2222. ; 53:11, s. 1198-1211
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https://uu.diva-port... (primary) (Raw object)
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Introduction: Eosinophil-derived neurotoxin (EDN) is related to childhood asthma, while normal values are lacking. We aimed to document serum EDN levels at 1 and 3 years in general and in non-atopic children, and explore if EDN levels differed by sex or were associated with preschool asthma at 3 years.Methods: From the PreventADALL birth cohort, we included 1233 children with EDN analysed using ImmunoCAP at 1 and/or 3 years. Non-atopic children had no history of wheeze, asthma, allergic sensitization or atopic dermatitis. Preschool asthma was defined as having ≥3 episodes of bronchial obstruction between 2 and 3 years, plus doctor diagnosed asthma and/or asthma medication use by 3 years. The upper limit of normal (ULN) of EDN was defined as the 95th percentile. With Youden Index we calculated EDN cut-off levels for risk of preschool asthma.Results: The overall median (ULN) EDN levels were 27.4 (121) μg/L at 1 year (n = 787), and 20.1 (87.8) μg/L at 3 years (n = 857). Non-atopic children had EDN levels of 24.0 (107) μg/L at 1 year (n = 147), and 17.3 (84.6) μg/L at 3 years (n = 173). EDN levels were higher in boys compared to girls; 32.0 (133) versus 24.5 (97.0) μg/L at 1 year, and 20.9 (96.3) versus 19.0 (72.4) μg/L at 3 years. Preschool asthma was observed in 109/892 (12.2%) children. Higher EDN levels at 1 (>26.7 μg/L) and 3 (≥20.5 μg/L) years were associated with preschool asthma; adjusted OR (95% CI) 2.20 (1.09, 4.41) and 4.68 (2.29, 9.55), respectively.Conclusion and Clinical Relevance: We report EDN values in early childhood, demonstrating higher levels at 1 compared to 3 years and in boys compared to girls at both ages. Higher EDN levels at both ages were associated with preschool asthma. However, EDN cut-off levels for preschool asthma were overall lower than the ULN of non-atopic children, limiting translation into clinical practice.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)

Keyword

PreventADALL
asthma
child
eosinophil-derived neurotoxin
sex
type 2 inflammation
wheeze

Publication and Content Type

ref (subject category)
art (subject category)

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