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Omega-3 Blood Level...
Omega-3 Blood Levels and Stroke Risk : A Pooled and Harmonized Analysis of 183 291 Participants From 29 Prospective Studies
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O'Keefe, James H. (author)
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- Lind, Lars (author)
- Uppsala universitet,Klinisk epidemiologi
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Harris, William S. (author)
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- O'Keefe, Evan L. (author)
- Karolinska Institutet
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Sala-Vila, Aleix (author)
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Attia, John (author)
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Garg, G. Manohar (author)
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Hure, Alexis (author)
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Sørensen Bork, Christian (author)
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Berg Schmidt, Erik (author)
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Krogh Venø, Stine (author)
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Chien, Kuo-Liong (author)
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Chen, Yun-Yu Amelia (author)
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Egert, Sarah (author)
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- Rudholm Feldreich, Tobias (author)
- Högskolan Dalarna,Medicinsk vetenskap
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- Ärnlöv, Johan, 1970- (author)
- Karolinska insitutet
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- Lind, Lars (author)
- Uppsala universitet,Klinisk epidemiologi
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Forouhi, Nita G. (author)
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- Marklund, Matti (author)
- Uppsala universitet,Klinisk nutrition och metabolism,The George Institute for Global Health, University of New South Wales, Newtown, Australia; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
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Pertiwi, Kamalita (author)
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Imamura, Fumiaki (author)
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de Mello Laaksonen, Vanessa (author)
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Uusitupa, W. Matti (author)
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Tuomilehto, Jaakko (author)
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Laakso, Markku (author)
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Lankinen, Maria Anneli (author)
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Laurin, Danielle (author)
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Carmichael, Pierre-Hugues (author)
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Lindsay, Joan (author)
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Leander, Karin (author)
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Laguzzi, Federica (author)
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Swenson, Brenton R. (author)
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Longstreth, William T. (author)
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Manson, JoAnn E. (author)
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Mora, Samia (author)
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Cook, Nancy R. (author)
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- Marklund, Matti (author)
- Uppsala universitet,Klinisk nutrition och metabolism,The George Institute for Global Health, University of New South Wales, Newtown, Australia; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
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Melo van Lent, Debora (author)
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Murphy, Rachel (author)
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Gudnason, Vilmundur (author)
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Ninomiya, Toshihara (author)
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Hirakawa, Yoichiro (author)
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Qian, Frank (author)
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Sun, Qi (author)
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Hu, Frank (author)
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Ardisson Korat, Andres V. (author)
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- Risérus, Ulf, 1967- (author)
- Uppsala universitet,Klinisk nutrition och metabolism
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Lázaro, Iolanda (author)
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Samieri, Cecilia (author)
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Le Goff, Mélanie (author)
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Helmer, Catherine (author)
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Steur, Marinka (author)
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Voortman, Trudy (author)
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Ikram, M. Kamran (author)
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Tanaka, Toshiko (author)
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Das, Jayanta K. (author)
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Ferrucci, Luigi (author)
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Bandinelli, Stefania (author)
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Tsai, Michael (author)
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Guan, Weihua (author)
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Garg, Parveen (author)
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Verschuren, W. M. Monique (author)
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Boer, Jolanda M. A. (author)
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Biokstra, Anneke (author)
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Virtanen, Jyrki (author)
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Wagner, Michael (author)
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Westra, Jason (author)
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Albuisson, Luc (author)
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Yamagishi, Kazumasa (author)
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Siscovick, David S. (author)
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Lemaitre, Rozenn N. (author)
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Mozaffarian, Dariush (author)
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(creator_code:org_t)
- American Heart Association, 2024
- 2024
- English.
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In: Stroke. - : American Heart Association. - 0039-2499 .- 1524-4628. ; 55:1, s. 50-58
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Subject headings
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- BACKGROUND:The effect of marine omega-3 PUFAs on risk of stroke remains unclear.METHODS:We investigated the associations between circulating and tissue omega-3 PUFA levels and incident stroke (total, ischemic, and hemorrhagic) in 29 international prospective cohorts. Each site conducted a de novo individual-level analysis using a prespecified analytical protocol with defined exposures, covariates, analytical methods, and outcomes; the harmonized data from the studies were then centrally pooled. Multivariable-adjusted HRs and 95% CIs across omega-3 PUFA quintiles were computed for each stroke outcome.RESULTS:Among 183 291 study participants, there were 10 561 total strokes, 8220 ischemic strokes, and 1142 hemorrhagic strokes recorded over a median of 14.3 years follow-up. For eicosapentaenoic acid, comparing quintile 5 (Q5, highest) with quintile 1 (Q1, lowest), total stroke incidence was 17% lower (HR, 0.83 [CI, 0.76–0.91]; P<0.0001), and ischemic stroke was 18% lower (HR, 0.82 [CI, 0.74–0.91]; P<0.0001). For docosahexaenoic acid, comparing Q5 with Q1, there was a 12% lower incidence of total stroke (HR, 0.88 [CI, 0.81–0.96]; P=0.0001) and a 14% lower incidence of ischemic stroke (HR, 0.86 [CI, 0.78–0.95]; P=0.0001). Neither eicosapentaenoic acid nor docosahexaenoic acid was associated with a risk for hemorrhagic stroke. These associations were not modified by either baseline history of AF or prevalent CVD.CONCLUSIONS:Higher omega-3 PUFA levels are associated with lower risks of total and ischemic stroke but have no association with hemorrhagic stroke.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- atrial fibrillation
- cerebrovascular disease
- fish
- fish oil
- stroke
Publication and Content Type
- ref (subject category)
- art (subject category)
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Stroke
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- By the author/editor
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O'Keefe, James H ...
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Lind, Lars
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Harris, William ...
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O'Keefe, Evan L.
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Sala-Vila, Aleix
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Attia, John
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show more...
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Garg, G. Manohar
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Hure, Alexis
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Sørensen Bork, C ...
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Berg Schmidt, Er ...
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Krogh Venø, Stin ...
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Chien, Kuo-Liong
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Chen, Yun-Yu Ame ...
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Egert, Sarah
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Rudholm Feldreic ...
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Ärnlöv, Johan, 1 ...
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Forouhi, Nita G.
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Marklund, Matti
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Pertiwi, Kamalit ...
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Imamura, Fumiaki
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de Mello Laakson ...
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Uusitupa, W. Mat ...
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Tuomilehto, Jaak ...
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Laakso, Markku
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Lankinen, Maria ...
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Laurin, Danielle
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Carmichael, Pier ...
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Lindsay, Joan
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Leander, Karin
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Laguzzi, Federic ...
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Swenson, Brenton ...
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Longstreth, Will ...
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Manson, JoAnn E.
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Mora, Samia
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Cook, Nancy R.
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Melo van Lent, D ...
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Murphy, Rachel
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Gudnason, Vilmun ...
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Ninomiya, Toshih ...
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Hirakawa, Yoichi ...
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Qian, Frank
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Sun, Qi
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Hu, Frank
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Ardisson Korat, ...
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Risérus, Ulf, 19 ...
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Lázaro, Iolanda
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Samieri, Cecilia
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Le Goff, Mélanie
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Helmer, Catherin ...
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Steur, Marinka
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Voortman, Trudy
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Ikram, M. Kamran
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Tanaka, Toshiko
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Das, Jayanta K.
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Ferrucci, Luigi
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Bandinelli, Stef ...
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Tsai, Michael
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Guan, Weihua
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Garg, Parveen
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Verschuren, W. M ...
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Boer, Jolanda M. ...
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Biokstra, Anneke
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Virtanen, Jyrki
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Wagner, Michael
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Westra, Jason
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Albuisson, Luc
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Yamagishi, Kazum ...
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Siscovick, David ...
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Lemaitre, Rozenn ...
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Mozaffarian, Dar ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
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Stroke
- By the university
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Uppsala University
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Karolinska Institutet
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Högskolan Dalarna