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Omega-3 Blood Level...
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O'Keefe, James H.
(author)
Omega-3 Blood Levels and Stroke Risk : A Pooled and Harmonized Analysis of 183 291 Participants From 29 Prospective Studies
- Article/chapterEnglish2024
Publisher, publication year, extent ...
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American Heart Association,2024
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-520257
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-520257URI
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https://doi.org/10.1161/STROKEAHA.123.044281DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:154636157URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:du-47667URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:238134264URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:155127405URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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BACKGROUND:The effect of marine omega-3 PUFAs on risk of stroke remains unclear.METHODS:We investigated the associations between circulating and tissue omega-3 PUFA levels and incident stroke (total, ischemic, and hemorrhagic) in 29 international prospective cohorts. Each site conducted a de novo individual-level analysis using a prespecified analytical protocol with defined exposures, covariates, analytical methods, and outcomes; the harmonized data from the studies were then centrally pooled. Multivariable-adjusted HRs and 95% CIs across omega-3 PUFA quintiles were computed for each stroke outcome.RESULTS:Among 183 291 study participants, there were 10 561 total strokes, 8220 ischemic strokes, and 1142 hemorrhagic strokes recorded over a median of 14.3 years follow-up. For eicosapentaenoic acid, comparing quintile 5 (Q5, highest) with quintile 1 (Q1, lowest), total stroke incidence was 17% lower (HR, 0.83 [CI, 0.76–0.91]; P<0.0001), and ischemic stroke was 18% lower (HR, 0.82 [CI, 0.74–0.91]; P<0.0001). For docosahexaenoic acid, comparing Q5 with Q1, there was a 12% lower incidence of total stroke (HR, 0.88 [CI, 0.81–0.96]; P=0.0001) and a 14% lower incidence of ischemic stroke (HR, 0.86 [CI, 0.78–0.95]; P=0.0001). Neither eicosapentaenoic acid nor docosahexaenoic acid was associated with a risk for hemorrhagic stroke. These associations were not modified by either baseline history of AF or prevalent CVD.CONCLUSIONS:Higher omega-3 PUFA levels are associated with lower risks of total and ischemic stroke but have no association with hemorrhagic stroke.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Lind, LarsUppsala universitet,Klinisk epidemiologi(Swepub:uu)larslind
(author)
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Harris, William S.
(author)
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O'Keefe, Evan L.Karolinska Institutet
(author)
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Sala-Vila, Aleix
(author)
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Attia, John
(author)
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Garg, G. Manohar
(author)
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Hure, Alexis
(author)
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Sørensen Bork, Christian
(author)
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Berg Schmidt, Erik
(author)
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Krogh Venø, Stine
(author)
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Chien, Kuo-Liong
(author)
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Chen, Yun-Yu Amelia
(author)
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Egert, Sarah
(author)
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Rudholm Feldreich, TobiasHögskolan Dalarna,Medicinsk vetenskap(Swepub:du)trf
(author)
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Ärnlöv, Johan,1970-Karolinska Institutet,Karolinska insitutet(Swepub:du)jan
(author)
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Lind, LarsUppsala universitet,Klinisk epidemiologi(Swepub:uu)larslind
(author)
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Forouhi, Nita G.
(author)
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Marklund, MattiUppsala universitet,Klinisk nutrition och metabolism,The George Institute for Global Health, University of New South Wales, Newtown, Australia; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA(Swepub:uu)matma701
(author)
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Pertiwi, Kamalita
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Imamura, Fumiaki
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de Mello Laaksonen, Vanessa
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Uusitupa, W. Matti
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Tuomilehto, Jaakko
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Laakso, Markku
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Lankinen, Maria Anneli
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Laurin, Danielle
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Carmichael, Pierre-Hugues
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Lindsay, Joan
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Leander, Karin
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Laguzzi, FedericaKarolinska Institutet
(author)
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Swenson, Brenton R.
(author)
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Longstreth, William T.
(author)
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Manson, JoAnn E.
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Mora, Samia
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Cook, Nancy R.
(author)
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Marklund, MattiUppsala universitet,Klinisk nutrition och metabolism,The George Institute for Global Health, University of New South Wales, Newtown, Australia; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA(Swepub:uu)matma701
(author)
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Melo van Lent, Debora
(author)
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Murphy, Rachel
(author)
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Gudnason, Vilmundur
(author)
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Ninomiya, Toshihara
(author)
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Hirakawa, Yoichiro
(author)
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Qian, Frank
(author)
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Sun, Qi
(author)
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Hu, Frank
(author)
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Ardisson Korat, Andres V.
(author)
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Risérus, Ulf,1967-Uppsala universitet,Klinisk nutrition och metabolism(Swepub:uu)ulfriser
(author)
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Lázaro, Iolanda
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Samieri, Cecilia
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Le Goff, Mélanie
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Helmer, Catherine
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Steur, Marinka
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Voortman, Trudy
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Ikram, M. Kamran
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Tanaka, Toshiko
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Das, Jayanta K.
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Ferrucci, Luigi
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Bandinelli, Stefania
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Tsai, Michael
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Guan, Weihua
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Garg, Parveen
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Verschuren, W. M. Monique
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Boer, Jolanda M. A.
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Biokstra, Anneke
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Virtanen, Jyrki
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Wagner, Michael
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Westra, Jason
(author)
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Albuisson, Luc
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Yamagishi, Kazumasa
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Siscovick, David S.
(author)
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Lemaitre, Rozenn N.
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Mozaffarian, Dariush
(author)
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Uppsala universitetKlinisk epidemiologi
(creator_code:org_t)
Related titles
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In:Stroke: American Heart Association55:1, s. 50-580039-24991524-4628
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Stroke
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O'Keefe, James H ...
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Lind, Lars
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Harris, William ...
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O'Keefe, Evan L.
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Sala-Vila, Aleix
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Attia, John
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Garg, G. Manohar
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Hure, Alexis
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Sørensen Bork, C ...
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Berg Schmidt, Er ...
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Krogh Venø, Stin ...
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Chien, Kuo-Liong
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Chen, Yun-Yu Ame ...
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Egert, Sarah
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Rudholm Feldreic ...
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Ärnlöv, Johan, 1 ...
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Forouhi, Nita G.
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Marklund, Matti
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Pertiwi, Kamalit ...
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Imamura, Fumiaki
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de Mello Laakson ...
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Uusitupa, W. Mat ...
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Tuomilehto, Jaak ...
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Laakso, Markku
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Lankinen, Maria ...
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Laurin, Danielle
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Carmichael, Pier ...
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Lindsay, Joan
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Leander, Karin
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Laguzzi, Federic ...
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Swenson, Brenton ...
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Longstreth, Will ...
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Manson, JoAnn E.
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Mora, Samia
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Cook, Nancy R.
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Melo van Lent, D ...
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Murphy, Rachel
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Gudnason, Vilmun ...
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Ninomiya, Toshih ...
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Hirakawa, Yoichi ...
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Qian, Frank
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Sun, Qi
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Hu, Frank
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Ardisson Korat, ...
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Risérus, Ulf, 19 ...
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Lázaro, Iolanda
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Samieri, Cecilia
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Le Goff, Mélanie
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Helmer, Catherin ...
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Steur, Marinka
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Voortman, Trudy
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Ikram, M. Kamran
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Tanaka, Toshiko
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Das, Jayanta K.
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Ferrucci, Luigi
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Bandinelli, Stef ...
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Tsai, Michael
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Guan, Weihua
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Garg, Parveen
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Verschuren, W. M ...
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Boer, Jolanda M. ...
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Biokstra, Anneke
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Virtanen, Jyrki
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Wagner, Michael
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Westra, Jason
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Albuisson, Luc
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Yamagishi, Kazum ...
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Siscovick, David ...
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Lemaitre, Rozenn ...
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Mozaffarian, Dar ...
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Stroke
- By the university
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Uppsala University
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Karolinska Institutet
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Högskolan Dalarna