Flavonoids as dual-target inhibitors against Î±-glucosidase and Î±-amylase: a systematic review of in vitro studies

Lam, Thua-PhongUppsala universitet,Institutionen för farmaci,Univ Med & Pharm Ho Chi Minh City, Fac Pharm, Ho Chi Minh City 700000, Vietnam. (author)

Flavonoids as dual-target inhibitors against Î±-glucosidase and Î±-amylase : a systematic review of in vitro studies

Diabetes mellitus remains a major global health issue, and great attention is directed at natural therapeutics. This systematic review aimed to assess the potential of flavonoids as antidiabetic agents by investigating their inhibitory effects on alpha-glucosidase and alpha-amylase, two key enzymes involved in starch digestion. Six scientific databases (PubMed, Virtual Health Library, EMBASE, SCOPUS, Web of Science, and WHO Global Index Medicus) were searched until August 21, 2022, for in vitro studies reporting IC50 values of purified flavonoids on alpha-amylase and alpha-glucosidase, along with corresponding data for acarbose as a positive control. A total of 339 eligible articles were analyzed, resulting in the retrieval of 1643 flavonoid structures. These structures were rigorously standardized and curated, yielding 974 unique compounds, among which 177 flavonoids exhibited inhibition of both alpha-glucosidase and alpha-amylase are presented. Quality assessment utilizing a modified CONSORT checklist and structure-activity relationship (SAR) analysis were performed, revealing crucial features for the simultaneous inhibition of flavonoids against both enzymes. Moreover, the review also addressed several limitations in the current research landscape and proposed potential solutions. The curated datasets are available online at https://github.com/MedChemUMP/FDIGA.

Tran, Ngoc-Vi NguyenUppsala universitet,Institutionen för farmaci,Univ Med & Pharm Ho Chi Minh City, Fac Pharm, Ho Chi Minh City 700000, Vietnam. (author)
Pham, Long-Hung DinhUniv Med & Pharm Ho Chi Minh City, Fac Pharm, Ho Chi Minh City 700000, Vietnam.;Imperial Coll London, Dept Chem, London W12 0BZ, England. (author)
Lai, Nghia Vo-TrongUniv Med & Pharm Ho Chi Minh City, Fac Pharm, Ho Chi Minh City 700000, Vietnam. (author)
Dang, Bao-Tran NgocUniv Med & Pharm Ho Chi Minh City, Fac Pharm, Ho Chi Minh City 700000, Vietnam. (author)
Truong, Ngoc-Lam NguyenUniv Med & Pharm Ho Chi Minh City, Fac Pharm, Ho Chi Minh City 700000, Vietnam. (author)
Nguyen-Vo, Song-KyUniv Med & Pharm Ho Chi Minh City, Fac Pharm, Ho Chi Minh City 700000, Vietnam. (author)
Hoang, Thuy-LinhCalif Northstate Univ, Coll Pharm, Elk Grove, CA 95757 USA. (author)
Mai, Tan ThanhUniv Med & Pharm Ho Chi Minh City, Fac Pharm, Ho Chi Minh City 700000, Vietnam. (author)
Tran, Thanh-DaoUniv Med & Pharm Ho Chi Minh City, Fac Pharm, Ho Chi Minh City 700000, Vietnam. (author)
Uppsala universitetInstitutionen för farmaci (creator_code:org_t)

By the author/editor: Lam, Thua-Phong; Tran, Ngoc-Vi Ng ...; Pham, Long-Hung ...; Lai, Nghia Vo-Tr ...; Dang, Bao-Tran N ...; Truong, Ngoc-Lam ...; show more...; Nguyen-Vo, Song- ...; Hoang, Thuy-Linh; Mai, Tan Thanh; Tran, Thanh-Dao; show less...

About the subject

AGRICULTURAL SCIENCES: AGRICULTURAL SCI ...; and Agriculture Fore ...; and Food Science

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