SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:DiVA.org:uu-521510"
 

Search: onr:"swepub:oai:DiVA.org:uu-521510" > Spatial multiomic i...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Nezhyva, MariyaUppsala universitet,Institutionen för farmaceutisk biovetenskap,Jansson group (author)

Spatial multiomic insights into acute cocaine exposure

  • BookEnglish

Publisher, publication year, extent ...

  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-521510
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-521510URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:vet swepub-contenttype
  • Subject category:ovr swepub-publicationtype

Notes

  • Recent studies provide compelling evidence that cocaine-induced neurotoxicity begins within hours of a single acute cocaine exposure. Despite this, a comprehensive understanding of the molecular alterations occurring in vivo within the reward system following such an exposure has been lacking. In this study, we developed an analytical workflow that combines mass spectrometry imaging with microscale proteomics of brain regions. Here, we present a multiomic perspective on the molecular consequences of acute cocaine exposure on the principal areas of the reward system and the hippocampus. Our findings include distinct region-specific alterations in the tricarboxylic acid (TCA) cycle and lipid synthesis within the reward circuitry highlighting a significant energy depletion in mice 24 hours post-cocaine injections. Additionally, we linked widespread reductions in key neurotransmitters (GABA, glutamate, aspartate) across the reward system and calcium level modifications to changes in synaptic plasticity and mitochondria dysfunction. Mitochondrial dysfunction and energy metabolism disruption were evident through imbalances in the mitochondrial ATP production and electron transport chain components, increased susceptibility to oxidative stress, disturbances in mitochondrial transport proteins, and fluctuations in creatine and taurine levels. Among the brain regions within the reward circuitry, the prefrontal cortex (PFC) exhibited the most pronounced effects. This study not only provides a holistic overview of the intricate interplay between proteins and metabolites within the reward circuitry regions during the onset of cocaine-induced neurotoxicity but also offers novel insights into the underlying molecular mechanisms.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Shahen, Samah (author)
  • Kabirova, Marina (author)
  • Bentov-Arav, Einav (author)
  • Shalev, Ori (author)
  • Andrén, Per E.,Professor,1957-Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Science for Life Laboratory, SciLifeLab(Swepub:uu)perandre (author)
  • Thornton, Claire (author)
  • Yaka, Rami (author)
  • Margulis, Katherine (author)
  • Jansson, Erik T.,Docent, tekn. dr.1984-Uppsala universitet,Institutionen för farmaceutisk biovetenskap(Swepub:uu)erija780 (author)
  • Uppsala universitetInstitutionen för farmaceutisk biovetenskap (creator_code:org_t)

Internet link

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view