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Plasma Protein Prof...
Plasma Protein Profiling of Incident Cardiovascular Diseases : A Multisample Evaluation
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- Lind, Lars (author)
- Uppsala universitet,Klinisk epidemiologi,Uppsala University, Uppsala
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- Titova, Olga (author)
- Uppsala universitet,Medicinsk epidemiologi,Uppsala University, Uppsala
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- Zeng, Rui (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Uppsala University, Uppsala
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- Zanetti, Daniela (author)
- Stanford Univ, Sch Med, Dept Med, Div Cardiovasc Med, Stanford, CA USA.,Stanford University School of Medicine, CA, US
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- Ingelsson, Martin (author)
- Uppsala universitet,Molekylär geriatrik,Uppsala University, Uppsala
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- Gustafsson, Stefan (author)
- Uppsala universitet,Klinisk epidemiologi,Uppsala University, Uppsala
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- Sundström, Johan, Professor, 1971- (author)
- Uppsala universitet,Klinisk epidemiologi,Uppsala University, Uppsala
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- Ärnlöv, Johan, 1970- (author)
- Högskolan Dalarna,Medicinsk vetenskap,Karolinska Institutet, Huddinge,Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Family Med & Primary Care, Huddinge, Sweden.;Dalarna Univ, Sch Hlth & Social Sci, Falun, Sweden.
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- Elmståhl, Sölve (author)
- Lund University,Lunds universitet,Geriatrik,Forskargrupper vid Lunds universitet,Geriatrics,Lund University Research Groups
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- Assimes, Themistocles (author)
- Stanford Univ, Sch Med, Dept Med, Div Cardiovasc Med, Stanford, CA USA.;Palo Alto VA Healthcare Syst, Palo Alto, CA USA.,Stanford University School of Medicine,VA Palo Alto Health Care System
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- Michaëlsson, Karl, 1959- (author)
- Uppsala universitet,Medicinsk epidemiologi,Uppsala University, Uppsala
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- Assimes, Tim (author)
- Uppsala University, Uppsala; Palo Alto VA Healthcare System, CA, US
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(creator_code:org_t)
- Wolters Kluwer, 2023
- 2023
- English.
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In: CIRCULATION-GENOMIC AND PRECISION MEDICINE. - : Wolters Kluwer. - 2574-8300. ; 16:6
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Abstract
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- BACKGROUND: Proteomic profiling could potentially disclose new pathophysiological pathways for cardiovascular diseases (CVD) and improve prediction at the individual level. We therefore aimed to study the plasma protein profile associated with the incidence of different CVDs.METHODS: Plasma levels of 245 proteins suspected to be linked to CVD or metabolism were measured in 4 Swedish prospective population-based cohorts (SIMPLER [Swedish Infrastructure for Medical Population-Based Life-Course and Environmental Research], ULSAM (Uppsala Longitudinal Study of Adult Men), EpiHealth, and POEM [Prospective Investigation of Obesity, Energy Production, and Metabolism]) comprising 11 869 individuals, free of CVD diagnoses at baseline. Our primary CVD outcome was defined by a combined end point that included either incident myocardial infarction, stroke, or heart failure.RESULTS: Using a discovery/validation approach, 42 proteins were associated with our primary composite end point occurring in 1163 subjects. In separate meta-analyses for each of the 3 CVD outcomes, 49 proteins were related to myocardial infarction, 34 to ischemic stroke, and 109 to heart failure. Thirteen proteins were related to all 3 outcomes. Of those, urokinase plasminogen activator surface receptor, adrenomedullin, and KIM-1 (kidney injury molecule 1) were also related to several markers of subclinical CVD in Prospective Investigation of Obesity, Energy production and Metabolism, reflecting myocardial or arterial pathologies. In prediction analysis, a lasso selection of 11 proteins in ULSAM improved the discrimination of CVD by 3.3% (P<0.0001) in SIMPLER when added to traditional risk factors.CONCLUSIONS: Protein profiling in multiple samples disclosed several new proteins to be associated with subsequent myocardial infarction, stroke, and heart failure, suggesting common pathophysiological pathways for these diseases. KIM-1, urokinase plasminogen activator surface receptor, and adrenomedullin were novel early markers of CVD. A selection of 11 proteins improved the discrimination of CVD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- biomarkers
- cardiovascular diseases
- heart failure
- ischemic stroke
- myocardial infarction
- biomarkers
- cardiovascular diseases
- heart failure
- ischemic stroke
- myocardial infarction
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Lind, Lars
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Titova, Olga
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Zeng, Rui
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Zanetti, Daniela
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Ingelsson, Marti ...
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Gustafsson, Stef ...
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Sundström, Johan ...
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Ärnlöv, Johan, 1 ...
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Elmståhl, Sölve
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Assimes, Themist ...
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Michaëlsson, Kar ...
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Assimes, Tim
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
- Articles in the publication
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CIRCULATION-GENO ...
- By the university
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Uppsala University
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Högskolan Dalarna
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Karolinska Institutet
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Lund University