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Influence of exposu...
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Flores-Chavez, A.Hosp Clin Barcelona, Dept Autoimmune Dis, ICMiD, Barcelona, Spain.
(författare)
Influence of exposure to climate-related hazards in the phenotypic expression of primary Sjögren's syndrome
- Artikel/kapitelEngelska2023
Förlag, utgivningsår, omfång ...
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Clinical and Experimental Rheumatology,2023
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-521893
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-521893URI
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https://doi.org/10.55563/clinexprheumatol/pmbay6DOI
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Språk:engelska
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Sammanfattning på:engelska
Ingår i deldatabas
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Objective To analyse how the key components at the time of diagnosis of the Sjogren's phenotype (epidemiological profile, sicca symptoms, and systemic disease) can be influenced by the potential exposure to climate-related natural hazards. Methods For the present study, the following variables were selected for harmonisation and refinement: age, sex, country, fulfilment of 2002/2016 criteria items, dry eyes, dry mouth, and overall ESSDAI score. Climate-related hazards per country were defined according to the OECD and included seven climate-related hazard types: extreme temperature, extreme precipitation, drought, wildfire, wind threats, river flooding, and coastal flooding. Climatic variables were defined as dichotomous variables according to whether each country is ranked among the ten countries with the most significant exposure. Results After applying data-cleaning techniques and excluding people from countries not included in the OECD climate rankings, the database study analysed 16,042 patients from 23 countries. The disease was diagnosed between 1 and 3 years earlier in people living in countries included among the top 10 worst exposed to extreme precipitation, wildfire, wind threats, river flooding, and coastal flooding. A lower frequency of dry eyes was observed in people living in countries exposed to wind threats, river flooding, and coastal flooding, with a level of statistical association being classified as strong (p<0.0001 for the three variables). The frequency of dry mouth was significantly lower in people living in countries exposed to river flooding (p<0.0001) and coastal flooding (p<0.0001). People living in countries included in the worse climate scenarios for extreme temperature (p<0.0001) and river flooding (p<0.0001) showed a higher mean ESSDAI score in comparison with people living in no-risk countries. In contrast, those living in countries exposed to worse climate scenarios for wind threats (p<0.0001) and coastal flooding (p<0.0001) showed a lower mean ESSDAI score in comparison with people living in no-risk countries. Conclusion Local exposure to extreme climate-related hazards plays a role in modulating the presentation of Sjogren across countries concerning the age at which the disease is diagnosed, the frequency of dryness, and the degree of systemic activity.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Brito-Zeron, P.Sanitas Digital Hosp, Hosp CIMA Ctr Med Milenium Balmes Sanitas, Autoimmune Dis Unit, Res & Innovat Grp Autoimmune Dis, Barcelona, Spain.
(författare)
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Ng, W. -f.Newcastle Univ, Translat & Clin Res Inst, Newcastle Upon Tyne, Northumberland, England.;Newcastle Tyne Hosp NHS Fdn Trust, NIHR Newcastle Biomed Res Ctr, Newcastle Upon Tyne, Tyne & Wear, England.
(författare)
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Szanto, A.Univ Debrecen, Fac Med, Div Rheumatol, Debrecen, Hungary.
(författare)
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Rasmussen, A.Oklahoma Med Res Fdn, Genes & Human Dis Res Program, Oklahoma City, OK USA.
(författare)
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Priori, R.Sapienza Univ, Dept Internal Med & Med Specialties, Rome, Italy.;St Camillus Int Univ Hlth Sci, UniCamillus, Rome, Italy.
(författare)
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Baldini, C.Univ Pisa, Rheumatol Unit, Pisa, Italy.
(författare)
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Armagan, B.Hacettepe Univ, Fac Med, Dept Internal Med, Div Rheumatol, Ankara, Turkey.
(författare)
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Oezkiziltas, B.Gazi Univ, Sch Med, Dept Internal Med, Div Rheumatol, Ankara, Turkey.
(författare)
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Praprotnik, S.Univ Med Ctr Ljubljana, Dept Rheumatol, Llubljana, Slovenia.
(författare)
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Suzuki, Y.Kanazawa Univ Hosp, Div Rheumatol, Kanazawa, Ishikawa, Japan.
(författare)
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Quartuccio, L.St Maria Misericordia Univ Hosp, Univ Udine, Inst Dermatol, Dept Expt & Clin Med, Piazzale St Maria Misericordia 15, I-33100 Udine, Italy.
(författare)
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Hernandez-Molina, G.Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Immunol & Rheumatol, Mexico City, Mexico.
(författare)
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Inanc, N.Marmara Univ, Sch Med, Istanbul, Turkey.
(författare)
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Bartoloni, E.Univ Perugia, Dept Med, Rheumatol Unit, Perugia, Italy.
(författare)
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Rischmueller, M.Univ Adelaide, Queen Elizabeth Hosp, Discipline Med, Woodville, SA 5011, Australia.
(författare)
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Oliveira, F. Reis-deUniv Sao Paulo, Dept Ribeirao Preto Med Sch, Ribeirao Preto, Brazil.
(författare)
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Trevisani, V. Fernandes MocaUniv Fed Sao Paulo, Evidence Based Hlth Postgrad Program, Sao Paulo, Brazil.
(författare)
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Jurcut, C.Dr Carol Davila Cent Mil Emergency Univ Hosp, Dept Gastroenterol & Internal Med, Bucharest, Romania.
(författare)
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Nordmark, GunnelUppsala universitet,Reumatologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)gunnnord
(författare)
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Carubbi, F.San Salvatore Hosp, Internal Med & Nephrol Unit, Laquila, Italy.
(författare)
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Hofauer, B.Tech Univ Munich, Dept Otorhinolaryngol Head & Neck Surg, Munich, Germany.
(författare)
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Valim, V.Univ Fed Espirito Santo HUCAM UFES EBSERH, Hosp Univ Cassiano Antonio Moraes, Vitoria, ES, Brazil.
(författare)
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Pasoto, S. G.Univ Sao Paulo, Hosp Clin HCFMUSP, Rheumatol Div, Fac Med, Sao Paulo, Brazil.
(författare)
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Retamozo, S.Quiron Salud Hosp, Badajoz, Spain.
(författare)
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Atzeni, F.Univ Messina, Rheumatol Unit, Messina, Italy.
(författare)
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Fonseca-Aizpuru, E.Hosp Cabuenes, Serv Med EMULSA, Gijon, Spain.
(författare)
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Lopez-Dupla, M.Fdn Policlin Univ, Campus Biomed Roma, Rome, Italy.
(författare)
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Giacomelli, R.Hosp Univ Joan XXIII, Dept Internal Med, Tarragona 43007, Spain.;Univ Campus Biomed Roma, Dept Med & Surg, Res Unit Neurol, Rome, Italy.
(författare)
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Nakamura, H.Nihon Univ, Sch Med, Dept Med, Div Hematol & Rheumatol,Itabashi Ku, Tokyo, Japan.
(författare)
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Akasbi, M.Univ Hosp Infanta Leonor, Dept Internal Med, Madrid, Spain.
(författare)
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Thompson, K.Newcastle Univ, Translat & Clin Res Inst, Newcastle Upon Tyne, Northumberland, England.;Newcastle Tyne Hosp NHS Fdn Trust, NIHR Newcastle Biomed Res Ctr, Newcastle Upon Tyne, Tyne & Wear, England.
(författare)
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Horvath, I. FannyUniv Debrecen, Fac Med, Div Rheumatol, Debrecen, Hungary.
(författare)
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Farris, A. D.Oklahoma Med Res Fdn, Genes & Human Dis Res Program, Oklahoma City, OK USA.
(författare)
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Simoncelli, E.Sapienza Univ, Dept Internal Med & Med Specialties, Rome, Italy.;St Camillus Int Univ Hlth Sci, UniCamillus, Rome, Italy.
(författare)
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Bombardieri, S.Univ Pisa, Rheumatol Unit, Pisa, Italy.
(författare)
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Kilic, L.Hacettepe Univ, Fac Med, Dept Internal Med, Div Rheumatol, Ankara, Turkey.
(författare)
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Tufan, A.Gazi Univ, Sch Med, Dept Internal Med, Div Rheumatol, Ankara, Turkey.
(författare)
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Pirkmajer, K. PerdanUniv Med Ctr Ljubljana, Dept Rheumatol, Llubljana, Slovenia.;Univ Ljubljana, Fac Med, Dept Internal Med, Ljubljana, Slovenia.
(författare)
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Fujisawa, Y.Kanazawa Univ Hosp, Div Rheumatol, Kanazawa, Ishikawa, Japan.
(författare)
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De Vita, S.St Maria Misericordia Univ Hosp, Univ Udine, Inst Dermatol, Dept Expt & Clin Med, Piazzale St Maria Misericordia 15, I-33100 Udine, Italy.
(författare)
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Abacar, K.Marmara Univ, Sch Med, Istanbul, Turkey.
(författare)
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Ramos-Casals, M.Hosp Clin Barcelona, Dept Autoimmune Dis, ICMiD, Barcelona, Spain.;Univ Barcelona, Dept Med, Barcelona, Spain.;Hosp Clin Barcelona, Serv Malalties Autoimmunes Sistem, C Villarroel 170, Barcelona 08036, Spain.
(författare)
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Hosp Clin Barcelona, Dept Autoimmune Dis, ICMiD, Barcelona, Spain.Sanitas Digital Hosp, Hosp CIMA Ctr Med Milenium Balmes Sanitas, Autoimmune Dis Unit, Res & Innovat Grp Autoimmune Dis, Barcelona, Spain.
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Clinical and Experimental Rheumatology: Clinical and Experimental Rheumatology41:12, s. 2437-24470392-856X1593-098X
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Till lärosätets databas
- Av författaren/redakt...
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Flores-Chavez, A ...
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Brito-Zeron, P.
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Ng, W. -f.
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Szanto, A.
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Rasmussen, A.
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Priori, R.
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visa fler...
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Baldini, C.
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Armagan, B.
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Oezkiziltas, B.
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Praprotnik, S.
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Suzuki, Y.
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Quartuccio, L.
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Hernandez-Molina ...
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Inanc, N.
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Bartoloni, E.
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Rischmueller, M.
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Oliveira, F. Rei ...
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Trevisani, V. Fe ...
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Jurcut, C.
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Nordmark, Gunnel
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Carubbi, F.
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Hofauer, B.
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Valim, V.
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Pasoto, S. G.
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Retamozo, S.
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Atzeni, F.
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Fonseca-Aizpuru, ...
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Lopez-Dupla, M.
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Giacomelli, R.
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Nakamura, H.
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Akasbi, M.
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Thompson, K.
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Horvath, I. Fann ...
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Farris, A. D.
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Simoncelli, E.
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Bombardieri, S.
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Kilic, L.
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Tufan, A.
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Pirkmajer, K. Pe ...
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Fujisawa, Y.
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De Vita, S.
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Abacar, K.
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Ramos-Casals, M.
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