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Screening for infla...
Screening for inflammatory markers identifies IL18-Rα as a potential link between exenatide and its anti-inflammatory effect : New results from the Combat-JUDO randomized controlled trial
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- Stenlid, Rasmus (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi,Institutionen för kvinnors och barns hälsa
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- Cerenius, Sara Y. (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
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- Manell, Hannes (author)
- Uppsala universitet,Pediatrisk inflammations- och metabolismforskning samt barnhälsa,Uppsala Univ Hosp, Childrens Obes Clin, Uppsala, Sweden.
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- Aydin, Banu K. (author)
- Uppsala universitet,Pediatrisk inflammations- och metabolismforskning samt barnhälsa
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- Mörwald, Katharina (author)
- Paracelsus Med Univ, Dept Pediat, Salzburg, Austria.
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- Gomahr, Julian (author)
- Paracelsus Med Univ, Dept Pediat, Salzburg, Austria.;Paracelsus Medial Univ, Obes Res Unit, Salzburg, Austria.
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- Höghammar Mitkas, Marina (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Institutionen för medicinsk cellbiologi
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- Eriksson, Ida (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
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- Ciba, Iris (author)
- Uppsala universitet,Pediatrisk inflammations- och metabolismforskning samt barnhälsa,Uppsala Univ Hosp, Childrens Obes Clin, Uppsala, Sweden.
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- Geiersberger, Sabine (author)
- Paracelsus Med Univ, Dept Pediat, Salzburg, Austria.;Paracelsus Medial Univ, Obes Res Unit, Salzburg, Austria.
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- Thivel, David (author)
- Clermont Auvergne Univ, Lab Metab Adaptat Exercise Physiol & Pathol Condit, Clermont Ferrand, France.
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- Weghuber, Daniel (author)
- Paracelsus Med Univ, Dept Pediat, Salzburg, Austria.;Paracelsus Medial Univ, Obes Res Unit, Salzburg, Austria.;Paracelsus Med Univ, Dept Pediat, MÃŒllner Hauptstr 48, A-5020 Salzburg, Austria.
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- Bergsten, Peter (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi,Pediatrisk inflammations- och metabolismforskning samt barnhälsa
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- Forslund, Anders, 1961- (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi,Pediatrisk inflammations- och metabolismforskning samt barnhälsa
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(creator_code:org_t)
- S. Karger, 2023
- 2023
- English.
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In: Annals of Nutrition and Metabolism. - : S. Karger. - 0250-6807 .- 1421-9697. ; 79:6, s. 522-527
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Introduction: Obesity is associated with chronic inflammation. Chronic inflammation has also been linked to insulin resistance and type 2 diabetes, non-alcoholic fatty liver disease and cardiovascular disease. Glucagon-like peptide-1 (GLP-1) receptor analogs (GLP-1RA) are clinically used to treat obesity, with known anti-inflammatory properties. How the GLP-1RA exenatide effects inflammation in adolescents with obesity is not fully investigated.Methods: 44 patients were randomized to receive weekly subcutaneous injections with either 2 mg exenatide or placebo for 6 months. Plasma samples were collected at baseline and at the end of the study, and 90 inflammatory proteins were measured.Results: Following treatment with exenatide, 15 out of the 90 proteins were decreased, and one was increased. However, after adjustment for multiple testing, only IL18-R alpha was significantly lowered following treatment.Conclusions: Weekly injections with 2 mg of exenatide lowers circulating IL18-R alpha in adolescents with obesity, which may be a potential link between exenatide and its anti-inflammatory effect in vivo. This contributes to exenatide's pharmaceutical potential as a treatment for obesity beyond weight control and glucose tolerance, and should be further studied mechanistically.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Keyword
- Obesity
- Inflammation
- GLP-1
- IL-18
- IL-18R alpha
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Stenlid, Rasmus
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Cerenius, Sara Y ...
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Manell, Hannes
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Aydin, Banu K.
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Mörwald, Kathari ...
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Gomahr, Julian
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Höghammar Mitkas ...
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Eriksson, Ida
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Ciba, Iris
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Geiersberger, Sa ...
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Thivel, David
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Weghuber, Daniel
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Bergsten, Peter
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Forslund, Anders ...
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- MEDICAL AND HEALTH SCIENCES
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and Endocrinology an ...
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and Gastroenterology ...
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MEDICAL AND HEAL ...
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and Pediatrics
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Uppsala University