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Effect of preoperat...
Effect of preoperative chemotherapy on the histopathological classification of gastric cancer
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- Caspers, I. A. (author)
- Netherlands Canc Inst, Antoni van Leeuwenhoek Hosp, Dept Gastrointestinal Oncol, Amsterdam, Netherlands.;Amsterdam Univ Med Ctr, Canc Ctr Amsterdam, Dept Pathol, Boelelaan 1117, NL-1081HV Amsterdam, Netherlands.
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- Biesma, H. D. (author)
- Amsterdam Univ Med Ctr, Canc Ctr Amsterdam, Dept Pathol, Boelelaan 1117, NL-1081HV Amsterdam, Netherlands.
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- Wiklund, K. (author)
- Karolinska Inst, Dept Oncol & Pathol, Stockholm, Sweden.
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- Pontén, Fredrik (author)
- Uppsala universitet,Cancerprecisionsmedicin
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- Lind, P. (author)
- Karolinska Institutet,Karolinska Inst, Dept Oncol & Pathol, Stockholm, Sweden.
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- Nordsmark, M. (author)
- Aarhus Univ Hosp, Dept Oncol, Aarhus, Denmark.
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- Sikorska, K. (author)
- Netherlands Canc Inst Antoni van Leeuwenhoek, Dept Biometr, Amsterdam, Netherlands.
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- Meershoek-KleinKranenbarg, E. (author)
- Leiden Univ Med Ctr, Dept Surg Oncol, Leiden, Netherlands.
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- Hartgrink, H. H. (author)
- Leiden Univ Med Ctr, Dept Surg Oncol, Leiden, Netherlands.
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- van de Velde, C. J. H. (author)
- Leiden Univ Med Ctr, Dept Surg Oncol, Leiden, Netherlands.
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- van Sandick, J. W. (author)
- Netherlands Canc Inst Antoni Van Leeuwenhoek, Dept Surg Oncol, Amsterdam, Netherlands.
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- Verheij, M. (author)
- Radboud Univ Nijmegen Med Ctr, Dept Radiat Oncol, Nijmegen, Netherlands.;Netherlands Canc Inst Antoni Van Leeuwenhoek, Dept Radiat Oncol, Amsterdam, Netherlands.
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- Cats, A. (author)
- Netherlands Canc Inst, Antoni van Leeuwenhoek Hosp, Dept Gastrointestinal Oncol, Amsterdam, Netherlands.
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- van Grieken, N. C. T. (author)
- Amsterdam Univ Med Ctr, Canc Ctr Amsterdam, Dept Pathol, Boelelaan 1117, NL-1081HV Amsterdam, Netherlands.
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Netherlands Canc Inst, Antoni van Leeuwenhoek Hosp, Dept Gastrointestinal Oncol, Amsterdam, Netherlands;Amsterdam Univ Med Ctr, Canc Ctr Amsterdam, Dept Pathol, Boelelaan 1117, NL-1081HV Amsterdam, Netherlands. Amsterdam Univ Med Ctr, Canc Ctr Amsterdam, Dept Pathol, Boelelaan 1117, NL-1081HV Amsterdam, Netherlands. (creator_code:org_t)
- Springer, 2024
- 2024
- English.
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In: Gastric Cancer. - : Springer. - 1436-3291 .- 1436-3305. ; 27, s. 102-109
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Abstract
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- Background: In the era of individualized gastric cancer (GC) treatment, accurate determination of histological subtype becomes increasingly relevant. As yet, it is unclear whether preoperative chemotherapy may affect the histological subtype. The aim of this study was to assess concordance in histological subtype between pretreatment biopsies and surgical resection specimens before and after the introduction of perioperative treatment.Methods: Histological subtype was centrally determined in paired GC biopsies and surgical resection specimens of patients treated with either surgery alone (SA) in the Dutch D1/D2 study or with preoperative chemotherapy (CT) in the CRITICS trial. The histological subtype as determined in the resection specimen was considered the gold standard. Concordance rates and sensitivity and specificity of intestinal, diffuse, mixed, and "other" subtypes of GC were analyzed.Results: In total, 105 and 515 pairs of GC biopsies and resection specimens of patients treated in the SA and CT cohorts, respectively, were included. Overall concordance in the histological subtype was 72% in the SA and 74% in the CT cohort and substantially higher in the diffuse subtype (83% and 86%) compared to the intestinal (70% and 74%), mixed (21% and 33%) and "other" subtypes (54% and 54%). In the SA cohort, sensitivities and specificities were 0.88 and 0.71 in the intestinal, 0.67 and 0.93 in the diffuse, 0.20 and 0.98 in the mixed, and 0.50 and 0.93 in the "other" subtypes, respectively.Conclusion: Our results suggest that accurate determination of histological subtype on gastric cancer biopsies is suboptimal but that the impact of preoperative chemotherapy on histological subtype is negligible.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Keyword
- Gastric cancer
- Lauren classification
- Histological subtype
- Concordance
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Caspers, I. A.
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Biesma, H. D.
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Wiklund, K.
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Pontén, Fredrik
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Lind, P.
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Nordsmark, M.
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show more...
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Sikorska, K.
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Meershoek-KleinK ...
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Hartgrink, H. H.
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van de Velde, C. ...
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van Sandick, J. ...
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Verheij, M.
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Cats, A.
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van Grieken, N. ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
- Articles in the publication
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Gastric Cancer
- By the university
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Uppsala University
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Karolinska Institutet