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  • Jin, YingCapital Med Univ, Beijing Tiantan Hosp, Dept Radiol, Beijing 100070, Peoples R China. (author)

"Soap bubble" sign as an imaging marker for posterior fossa ependymoma Group B

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • Springer,2023
  • printrdacarrier

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  • LIBRIS-ID:oai:DiVA.org:uu-522785
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-522785URI
  • https://doi.org/10.1007/s00234-023-03231-9DOI

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  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Purpose: To investigate the predictive value of the "soap bubble" sign on molecular subtypes (Group A [PFA] and Group B [PFB]) of posterior fossa ependymomas (PF-EPNs).Methods: MRI scans of 227 PF-EPNs (internal retrospective discovery set) were evaluated by two independent neuroradiologists to assess the "soap bubble" sign, which was defined as clusters of cysts of various sizes that look like "soap bubbles" on T2-weighted images. Two independent cohorts (external validation set [n = 31] and prospective validation set [n = 27]) were collected to validate the "soap bubble" sign.Results: Across three datasets, the "soap bubble" sign was observed in 21 PFB cases (7.4% [21/285] of PF-EPNs and 12.9% [21/163] of PFB); none in PFA. Analysis of the internal retrospective discovery set demonstrated substantial interrater agreement (1st Rating: kappa = 0.71 [0.53-0.90], 2nd Rating: kappa = 0.83 [0.68-0.98]) and intrarater agreement (Rater 1: kappa = 0.73 [0.55-0.91], Rater 2: kappa = 0.74 [0.55-0.92]) for the "soap bubble" sign; all 13 cases positive for the "soap bubble" sign were PFB (p = 0.002; positive predictive value [PPV] = 100%, negative predictive value [NPV] = 44%, sensitivity = 10%, specificity = 100%). The findings from the external validation set and the prospective validation set were similar, all cases positive for the "soap bubble" sign were PFB (p < 0.001; PPV = 100%).Conclusion: The "soap bubble" sign represents a highly specific imaging marker for the PFB molecular subtype of PF-EPNs.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Cheng, DanCapital Med Univ, Beijing Tiantan Hosp, Dept Radiol, Beijing 100070, Peoples R China. (author)
  • Duan, YunyunCapital Med Univ, Beijing Tiantan Hosp, Dept Radiol, Beijing 100070, Peoples R China. (author)
  • Zhuo, ZhizhengCapital Med Univ, Beijing Tiantan Hosp, Dept Radiol, Beijing 100070, Peoples R China. (author)
  • Weng, JinyuanNeusoft Grp Ltd, Dept Med Imaging Prod, Shenyang 110179, Peoples R China. (author)
  • Zhang, ChengzhouYantai Yuhuangding Hosp, Dept Radiol, Yantai 264000, Shandong, Peoples R China. (author)
  • Zhu, MingwangCapital Med Univ, Sanbo Brain Hosp, Dept Radiol, Beijing 100070, Peoples R China. (author)
  • Liu, XingCapital Med Univ, Beijing Tiantan Hosp, Dept Pathol, Beijing 100070, Peoples R China. (author)
  • Du, JiangCapital Med Univ, Beijing Tiantan Hosp, Dept Pathol, Beijing 100070, Peoples R China. (author)
  • Hua, TiantianCapital Med Univ, Beijing Tiantan Hosp, Dept Radiol, Beijing 100070, Peoples R China. (author)
  • Li, HongfangCapital Med Univ, Beijing Tiantan Hosp, Dept Radiol, Beijing 100070, Peoples R China. (author)
  • Haller, SvenUppsala universitet,Radiologi,Capital Med Univ, Beijing Tiantan Hosp, Dept Radiol, Beijing 100070, Peoples R China.;CIMC Ctr Imagerie Med Cornavin, Geneva, Switzerland.;Univ Geneva, Fac Med, Geneva, Switzerland.(Swepub:uu)sveha228 (author)
  • Barkhof, FrederikVrije Univ, Dept Radiol & Nucl Med, Amsterdam UMC, Amsterdam, Netherlands.;UCL, Queen Sq Inst Neurol, London, England.;UCL, Ctr Med Image Comp, London, England. (author)
  • Liu, YaouCapital Med Univ, Beijing Tiantan Hosp, Dept Radiol, Beijing 100070, Peoples R China. (author)
  • Capital Med Univ, Beijing Tiantan Hosp, Dept Radiol, Beijing 100070, Peoples R China.Neusoft Grp Ltd, Dept Med Imaging Prod, Shenyang 110179, Peoples R China. (creator_code:org_t)

Related titles

  • In:Neuroradiology: Springer65, s. 1707-17140028-39401432-1920

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