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Sustained IFN signa...
Sustained IFN signaling is associated with delayed development of SARS-CoV-2-specific immunity
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Brunet-Ratnasingham, Elsa (author)
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Morin, Sacha (author)
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Randolph, Haley E. (author)
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Labrecque, Marjorie (author)
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Bélair, Justin (author)
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Lima-Barbosa, Raphaël (author)
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Pagliuzza, Amélie (author)
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Marchitto, Lorie (author)
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- Hultström, Michael, 1978- (author)
- Uppsala universitet,Anestesiologi och intensivvård,Institutionen för medicinsk cellbiologi
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Niessl, Julia (author)
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Cloutier, Rose (author)
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Sreng Flores, Alina M. (author)
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Brassard, Nathalie (author)
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Benlarbi, Mehdi (author)
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Prévost, Jérémie (author)
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Ding, Shilei (author)
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Anand, Sai Priya (author)
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Sannier, Gérémy (author)
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Bareke, Eric (author)
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Zeberg, Hugo (author)
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- Lipcsey, Miklós (author)
- Uppsala universitet,Anestesiologi och intensivvård
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- Frithiof, Robert (author)
- Uppsala universitet,Anestesiologi och intensivvård
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- Larsson, Anders (author)
- Uppsala universitet,Klinisk kemi
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Zhou, Sirui (author)
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Nakanishi, Tomoko (author)
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Morrison, David (author)
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Vezina, Dani (author)
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Bourassa, Catherine (author)
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Gendron-Lepage, Gabrielle (author)
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Medjahed, Halima (author)
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Point, Floriane (author)
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Richard, Jonathan (author)
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Larochelle, Catherine (author)
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Prat, Alexandre (author)
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Arbour, Nathalie (author)
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Durand, Madeleine (author)
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Brent Richards, J (author)
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Moon, Kevin (author)
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Chomont, Nicolas (author)
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Finzi, Andrés (author)
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Tétreault, Martine (author)
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Barreiro, Luis (author)
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Wolf, Guy (author)
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Kaufmann, Daniel E. (author)
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(creator_code:org_t)
- 2023
- English.
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Plasma RNAemia, delayed antibody responses and inflammation predict COVID-19 outcomes, but the mechanisms underlying these immunovirological patterns are poorly understood. We profile 782 longitudinal plasma samples from 318 hospitalized COVID-19 patients. Integrated analysis using k-means reveal four patient clusters in a discovery cohort: mechanically ventilated critically-ill cases are subdivided into good prognosis and high-fatality clusters (reproduced in a validation cohort), while non-critical survivors are delineated by high and low antibody responses. Only the high-fatality cluster is enriched for transcriptomic signatures associated with COVID-19 severity, and each cluster has distinct RBD-specific antibody elicitation kinetics. Both critical and non-critical clusters with delayed antibody responses exhibit sustained IFN signatures, which negatively correlate with contemporaneous RBD-specific IgG levels and absolute SARS-CoV-2-specific B and CD4+ T cell frequencies. These data suggest that the “Interferon paradox” previously described in murine LCMV models is operative in COVID-19, with excessive IFN signaling delaying development of adaptive virus-specific immunity.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)
Publication and Content Type
- vet (subject category)
- ovr (subject category)
To the university's database
- By the author/editor
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Brunet-Ratnasing ...
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Morin, Sacha
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Randolph, Haley ...
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Labrecque, Marjo ...
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Bélair, Justin
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Lima-Barbosa, Ra ...
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show more...
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Pagliuzza, Améli ...
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Marchitto, Lorie
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Hultström, Micha ...
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Niessl, Julia
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Cloutier, Rose
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Sreng Flores, Al ...
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Brassard, Nathal ...
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Benlarbi, Mehdi
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Prévost, Jérémie
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Ding, Shilei
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Anand, Sai Priya
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Sannier, Gérémy
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Bareke, Eric
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Zeberg, Hugo
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Lipcsey, Miklós
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Frithiof, Robert
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Larsson, Anders
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Zhou, Sirui
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Nakanishi, Tomok ...
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Morrison, David
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Vezina, Dani
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Bourassa, Cather ...
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Gendron-Lepage, ...
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Medjahed, Halima
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Point, Floriane
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Richard, Jonatha ...
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Larochelle, Cath ...
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Prat, Alexandre
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Arbour, Nathalie
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Durand, Madelein ...
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Brent Richards, ...
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Moon, Kevin
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Chomont, Nicolas
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Finzi, Andrés
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Tétreault, Marti ...
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Barreiro, Luis
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Wolf, Guy
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Kaufmann, Daniel ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Anesthesiology a ...
- By the university
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Uppsala University