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Lysicamine Reduces ...
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Rodrigues, Mariana TeixeiraUniv Fed Sao Paulo UNIFESP, Thyroid Mol Sci Lab, BR-04021001 Sao Paulo, Brazil.;Univ Fed Sao Paulo UNIFESP, Struct & Funct Biol Postgrad Program, BR-04021001 Sao Paulo, Brazil.;Univ Fed Sao Paulo UNIFESP, Canc Mol Biol Lab, BR-04021001 Sao Paulo, Brazil.
(author)
Lysicamine Reduces Protein Kinase B (AKT) Activation and Promotes Necrosis in Anaplastic Thyroid Cancer
- Article/chapterEnglish2023
Publisher, publication year, extent ...
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MDPI,2023
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electronicrdacarrier
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LIBRIS-ID:oai:DiVA.org:uu-523330
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-523330URI
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https://doi.org/10.3390/ph16121687DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Anaplastic thyroid cancer (ATC) is an aggressive form of thyroid cancer (TC), accounting for 50% of total TC-related deaths. Although therapeutic approaches against TC have improved in recent years, the survival rate remains low, and severe adverse effects are commonly reported. However, unexplored alternatives based on natural compounds, such as lysicamine, an alkaloid found in plants with established cytotoxicity against breast and liver cancers, offer promise. Therefore, this study aimed to explore the antineoplastic effects of lysicamine in papillary TC (BCPAP) and ATC (HTH83 and KTC-2) cells. Lysicamine treatment reduced cell viability, motility, colony formation, and AKT activation while increasing the percentage of necrotic cells. The absence of caspase activity confirmed apoptosis-independent cell death. Necrostatin-1 (NEC-1)-mediated necrosome inhibition reduced lysicamine-induced necrosis in KTC-2, suggesting necroptosis induction via a reactive oxygen species (ROS)-independent mechanism. Additionally, in silico analysis predicted lysicamine target proteins, particularly those related to MAPK and TGF-beta signaling. Our study demonstrated lysicamine's potential as an antineoplastic compound in ATC cells with a proposed mechanism related to inhibiting AKT activation and inducing cell death.
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Michelli, Ana Paula PicaroUniv Fed Sao Paulo UNIFESP, Thyroid Mol Sci Lab, BR-04021001 Sao Paulo, Brazil.;Univ Fed Sao Paulo UNIFESP, Canc Mol Biol Lab, BR-04021001 Sao Paulo, Brazil.
(author)
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Caso, Gustavo FelisolaUniv Fed Sao Paulo UNIFESP, Thyroid Mol Sci Lab, BR-04021001 Sao Paulo, Brazil.;Univ Fed Sao Paulo UNIFESP, Canc Mol Biol Lab, BR-04021001 Sao Paulo, Brazil.
(author)
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de Oliveira, Paloma RamosUniv Fed Sao Paulo UNIFESP, Thyroid Mol Sci Lab, BR-04021001 Sao Paulo, Brazil.;Univ Fed Sao Paulo UNIFESP, Canc Mol Biol Lab, BR-04021001 Sao Paulo, Brazil.
(author)
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Mendes Rodrigues Junior, DorivalUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab,Uppsala Univ, Biomed Ctr, Dept Med Biochem & Microbiol, Sci Life Lab, S-75236 Uppsala, Sweden.(Swepub:uu)dorme120
(author)
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Morale, Mirian GallioteUniv Fed Sao Paulo UNIFESP, Canc Mol Biol Lab, BR-04021001 Sao Paulo, Brazil.
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Machado Junior, JoelUniv Fed Sao Paulo UNIFESP, Biol Sci Dept, BR-09920000 Diadema, Brazil.
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Bortoluci, Karina RamalhoUniv Fed Sao Paulo UNIFESP, Pharmacol Dept, Escola Paulista Med, BR-04021001 Sao Paulo, Brazil.
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Tamura, Rodrigo EsakiUniv Fed Sao Paulo UNIFESP, Canc Mol Biol Lab, BR-04021001 Sao Paulo, Brazil.;Univ Fed Sao Paulo UNIFESP, Biol Sci Dept, BR-09920000 Diadema, Brazil.;Univ Fed Sao Paulo UNIFESP, Inst Environm Chem & Pharmaceut Sci, Biol Chem Postgrad Program, BR-09920000 Diadema, Brazil.
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da Silva, Tamiris Reissa CiprianoUniv Fed Sao Paulo UNIFESP, Inst Environm Chem & Pharmaceut Sci, Dept Chem, BR-09920000 Diadema, Brazil.
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Raminelli, CristianoUniv Fed Sao Paulo UNIFESP, Inst Environm Chem & Pharmaceut Sci, Dept Chem, BR-09920000 Diadema, Brazil.
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Chau, EricHouston Methodist Res Inst, Dept Nanomed, Houston, TX 77030 USA.
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Godin, BianaHouston Methodist Res Inst, Dept Nanomed, Houston, TX 77030 USA.;Weill Cornell Med Coll, Dept Obstet & Gynecol, New York, NY 10065 USA.
(author)
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Calil-Silveira, JamileUniv Fed Sao Paulo UNIFESP, Thyroid Mol Sci Lab, BR-04021001 Sao Paulo, Brazil.;Univ Nove de Julho, Hlth Board 3, BR-01525000 Sao Paulo, Brazil.
(author)
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Rubio, Ileana G. SanchezUniv Fed Sao Paulo UNIFESP, Thyroid Mol Sci Lab, BR-04021001 Sao Paulo, Brazil.;Univ Fed Sao Paulo UNIFESP, Struct & Funct Biol Postgrad Program, BR-04021001 Sao Paulo, Brazil.;Univ Fed Sao Paulo UNIFESP, Canc Mol Biol Lab, BR-04021001 Sao Paulo, Brazil.;Univ Fed Sao Paulo UNIFESP, Biol Sci Dept, BR-09920000 Diadema, Brazil.
(author)
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Univ Fed Sao Paulo UNIFESP, Thyroid Mol Sci Lab, BR-04021001 Sao Paulo, Brazil.;Univ Fed Sao Paulo UNIFESP, Struct & Funct Biol Postgrad Program, BR-04021001 Sao Paulo, Brazil.;Univ Fed Sao Paulo UNIFESP, Canc Mol Biol Lab, BR-04021001 Sao Paulo, Brazil.Univ Fed Sao Paulo UNIFESP, Thyroid Mol Sci Lab, BR-04021001 Sao Paulo, Brazil.;Univ Fed Sao Paulo UNIFESP, Canc Mol Biol Lab, BR-04021001 Sao Paulo, Brazil.
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In:Pharmaceuticals: MDPI16:121424-8247
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