SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:DiVA.org:uu-523334"
 

Search: onr:"swepub:oai:DiVA.org:uu-523334" > Influenza-A mediate...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Influenza-A mediated pre-existing immunity levels to SARS-CoV-2 could predict early COVID-19 outbreak dynamics

Almazan, Nerea Martin (author)
Karolinska Inst, Dept Med, Unit Microbial Pathogenesis, S-17164 Stockholm, Sweden.;Karolinska Univ Hosp, Dept Neurol, S-17176 Stockholm, Sweden.;Karolinska Inst, Dept Lab Med, Div Pathol, S-14186 Stockholm, Sweden.
Rahbar, Afsar (author)
Karolinska Inst, Dept Med, Unit Microbial Pathogenesis, S-17164 Stockholm, Sweden.;Karolinska Univ Hosp, Dept Neurol, S-17176 Stockholm, Sweden.
Carlsson, Marcus (author)
Lund Univ, Ctr Math Sci, S-22362 Lund, Sweden.
show more...
Hoffman, Tove (author)
Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Infektionsmedicin,Uppsala Univ, Zoonosis Sci Ctr ZSC, Dept Med Biochem & Microbiol IMBIM, S-1477 Uppsala, Sweden.
Kolstad, Linda (author)
Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Uppsala Univ, Zoonosis Sci Ctr ZSC, Dept Med Biochem & Microbiol IMBIM, S-1477 Uppsala, Sweden.
Rönnberg, Bengt (author)
Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Uppsala Univ, Zoonosis Sci Ctr ZSC, Dept Med Biochem & Microbiol IMBIM, S-1477 Uppsala, Sweden.
Pantalone, Mattia Russel (author)
Karolinska Institutet,Karolinska Inst, Dept Med, Unit Microbial Pathogenesis, S-17164 Stockholm, Sweden.;Karolinska Univ Hosp, Dept Neurol, S-17176 Stockholm, Sweden.
Fuchs, Ilona Lewensohn (author)
Karolinska Inst, Dept Lab Med, Div Clin Microbiol, S-14186 Stockholm, Sweden.;Karolinska Univ Hosp, Dept Clin Microbiol, S-14186 Stockholm, Sweden.
Naucler, Anna (author)
Karolinska Inst, Dept Med, Unit Microbial Pathogenesis, S-17164 Stockholm, Sweden.
Ohlin, Mats (author)
Lund Univ, Dept Immunotechnol, S-22362 Lund, Sweden.;Lund Univ, SciLifeLab Human Antibody Therapeut Infrastruct Un, S-22362 Lund, Sweden.
Sacharczuk, Mariusz (author)
Med Univ Warsaw, Fac Pharm, Ctr Preclin Res & Technol, Dept Pharmacodynam,Lab Med Div, Banacha 1B, PL-02091 Warsaw, Poland.;Polish Acad Sci, Inst Genet & Anim Biotechnol, Dept Expt Genom, Postepu 36A, PL-05552 Magdalenka, Poland.
Religa, Piotr (author)
Karolinska Inst, Dept Med, Unit Microbial Pathogenesis, S-17164 Stockholm, Sweden.;Karolinska Univ Hosp, Dept Neurol, S-17176 Stockholm, Sweden.;Polish Acad Sci, Inst Genet & Anim Biotechnol, Dept Expt Genom, Postepu 36A, PL-05552 Magdalenka, Poland.
Amer, Stefan (author)
Familjelakarna Saltsjdbaden, S-13334 Saltsjdbaden, Sweden.
Molnar, Christian (author)
Familjelakarna Saltsjdbaden, S-13334 Saltsjdbaden, Sweden.;Karolinska Inst, Dept Neurobiol Care Sci & Soc, NVS, S-17177 Stockholm, Sweden.
Lundkvist, Ake (author)
Susrud, Andres (author)
Immunor AS, N-0349 Oslo, Norway.
Sorensen, Birger (author)
Immunor AS, N-0349 Oslo, Norway.
Soderberg-Naucler, Cecilia (author)
Karolinska Inst, Dept Med, Unit Microbial Pathogenesis, S-17164 Stockholm, Sweden.;Karolinska Univ Hosp, Dept Neurol, S-17176 Stockholm, Sweden.;Univ Turku, Inst Biomed, Unit Infect & Immunol, MediCity Res Lab, FI-20014 Turku, Finland.
show less...
Karolinska Inst, Dept Med, Unit Microbial Pathogenesis, S-17164 Stockholm, Sweden;Karolinska Univ Hosp, Dept Neurol, S-17176 Stockholm, Sweden.;Karolinska Inst, Dept Lab Med, Div Pathol, S-14186 Stockholm, Sweden. Karolinska Inst, Dept Med, Unit Microbial Pathogenesis, S-17164 Stockholm, Sweden.;Karolinska Univ Hosp, Dept Neurol, S-17176 Stockholm, Sweden. (creator_code:org_t)
CELL PRESS, 2023
2023
English.
In: iScience. - : CELL PRESS. - 2589-0042. ; 26:12
Related links:
https://doi.org/10.1...
show more...
https://urn.kb.se/re...
https://doi.org/10.1...
http://kipublication...
show less...
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • Susceptibility to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections is highly variable and could be mediated by a cross-protective pre-immunity. We identified 14 cross-reactive peptides between SARS-CoV-2 and influenza A H1N1, H3N2, and human herpesvirus (HHV)-6A/B with potential relevance. The H1N1 peptide NGVEGF was identical to a peptide in the most critical receptor binding motif in SARS-CoV-2 spike protein that interacts with the angiotensin converting enzyme 2 receptor. About 62%-73% of COVID-19-negative blood donors in Stockholm had antibodies to this peptide in the early pre-vaccination phase of the pandemic. Seasonal flu vaccination enhanced neutralizing capacity to SARS-CoV-2 and T cell immunity to this peptide. Mathematical modeling taking the estimated pre -immunity levels to flu into account could fully predict pre-Omicron SARS-CoV-2 outbreaks in Stockholm and India. This cross-immunity provides mechanistic explanations to the epidemiological observation that influenza vaccination protected people against early SARS-CoV-2 infections and implies that flu-mediated cross-protective immunity significantly dampened the first SARS-CoV-2 outbreaks.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Infectious Medicine (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Immunology in the medical area (hsv//eng)

Publication and Content Type

ref (subject category)
art (subject category)

Find in a library

  • iScience (Search for host publication in LIBRIS)

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view