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  • Heo, Rachel HaeeunUniv Toronto, Dept Med, Toronto, ON, Canada.;McMaster Univ, Populat Hlth Res Inst, Hamilton, ON, Canada. (author)

Associations of Inflammatory Biomarkers With the Risk of Morbidity and Mortality After Cardiac Surgery : A Systematic Review and Meta-analysis

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • Elsevier,2023
  • printrdacarrier

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  • LIBRIS-ID:oai:DiVA.org:uu-523447
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-523447URI
  • https://doi.org/10.1016/j.cjca.2023.07.021DOI

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  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:for swepub-publicationtype

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  • Background: Although inflammatory biomarkers have been associated with cardiovascular events in nonsurgical settings, these associations have not been systematically addressed in patients undergoing cardiac surgery. This review aimed to evaluate the relationships of inflammatory markers with mortality and adverse cardiovascular events in patients undergoing cardiac surgery. Methods: Medline, Embase, and Central databases were systematically searched for studies reporting pre-or postoperative levels of inflammatory biomarkers in patients undergoing cardiac surgery. Outcomes of interest were postoperative mortality, nonfatal myocardial infarction, stroke, congestive heart failure, and major adverse cardiovascular events (MACE). Studies reporting multivariable adjusted risk estimates were included. Risk estimates were pooled with the use of random-effects models and reported as summary odds ratios (ORs).Results: Among 14,465 citations identified, 29 studies including 29,401 participants met the eligibility criteria. The average follow-up time after surgery was 31 months. Preoperative C-reactive protein (CRP) levels were associated with an increased risk of all-cause mortality (OR 1.88, 95% CI 1.60-2.20; I2 = 19%; 11 studies) and MACE (OR 1.73, 95% CI 1.34-2.24; I2 = 0%; 3 studies). CRP levels measured on postoperative day 6 (OR 7.4, 95% CI 2.90-18.88, 1 study) and day 10 (OR 11.8, 95% CI 3.50-39.78, 1 study) were associated with a higher risk of all-cause mortality. Less, but overall similar, information was available for other inflammatory biomarkers. Conclusions: In this large meta-analysis, inflammatory biomarkers measured before or after cardiac surgery were associated with mortality and adverse cardiovascular outcomes in patients undergoing cardiac surgery.

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  • Wang, Michael KeMcMaster Univ, Populat Hlth Res Inst, Hamilton, ON, Canada.;McMaster Univ, Dept Med, Hamilton, ON, Canada.;McMaster Univ, Dept Hlth Res Methods Evidence & Impact, Hamilton, ON, Canada. (author)
  • Meyre, Pascal B.Univ Hosp Basel, Cardiovasc Res Inst Basel, Basel, Switzerland.;Univ Hosp Basel, Div Cardiol, Basel, Switzerland. (author)
  • Birchenough, LaurenMcMaster Univ, Fac Hlth Sci, Hamilton, ON, Canada. (author)
  • Park, LouisMcMaster Univ, Fac Hlth Sci, Hamilton, ON, Canada. (author)
  • Vuong, KivenWestern Univ, Fac Hlth Sci, London, ON, Canada. (author)
  • Devereaux, P. J.McMaster Univ, Populat Hlth Res Inst, Hamilton, ON, Canada.;McMaster Univ, Dept Med, Hamilton, ON, Canada.;McMaster Univ, Dept Hlth Res Methods Evidence & Impact, Hamilton, ON, Canada. (author)
  • Blum, SteffenMcMaster Univ, Populat Hlth Res Inst, Hamilton, ON, Canada.;Univ Hosp Basel, Cardiovasc Res Inst Basel, Basel, Switzerland.;Univ Hosp Basel, Div Cardiol, Basel, Switzerland. (author)
  • Lindahl, Bertil,1957-Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)belin227 (author)
  • Stone, GreggIcahn Sch Med Mt Sinai, Michael A Wiener Cardiovasc Inst, New York, NY USA.;Cardiovasc Res Fdn, New York, NY USA. (author)
  • Conen, DavidMcMaster Univ, Populat Hlth Res Inst, Hamilton, ON, Canada.;McMaster Univ, Dept Med, Hamilton, ON, Canada.;McMaster Univ, Dept Hlth Res Methods Evidence & Impact, Hamilton, ON, Canada.;Populat Hlth Res Inst, 237 Barton St East, Hamilton, ON L8L 2X2, Canada. (author)
  • Univ Toronto, Dept Med, Toronto, ON, Canada.;McMaster Univ, Populat Hlth Res Inst, Hamilton, ON, Canada.McMaster Univ, Populat Hlth Res Inst, Hamilton, ON, Canada.;McMaster Univ, Dept Med, Hamilton, ON, Canada.;McMaster Univ, Dept Hlth Res Methods Evidence & Impact, Hamilton, ON, Canada. (creator_code:org_t)

Related titles

  • In:Canadian Journal of Cardiology: Elsevier39:11, s. 1686-16940828-282X1916-7075

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