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Key interaction net...
Key interaction networks : Identifying evolutionarily conserved non-covalent interaction networks across protein families
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- Yehorova, Dariia (author)
- Georgia Inst Technol, Sch Chem & Biochem, Atlanta, GA 30332 USA.
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- Crean, Rory M. (author)
- Uppsala universitet,Biokemi
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- Kasson, Peter M. (author)
- Uppsala universitet,Molekylär biofysik,Univ Virginia, Dept Mol Physiol, Charlottesville, VA 22903 USA; Univ Virginia, Dept Biomed Engn, Charlottesville, VA USA
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- Kamerlin, Shina C. L., 1981- (author)
- Uppsala universitet,Biokemi,Georgia Inst Technol, Sch Chem & Biochem, Atlanta, GA 30332 USA
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Georgia Inst Technol, Sch Chem & Biochem, Atlanta, GA 30332 USA Biokemi (creator_code:org_t)
- John Wiley & Sons, 2024
- 2024
- English.
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In: Protein Science. - : John Wiley & Sons. - 0961-8368 .- 1469-896X. ; 33:3
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Abstract
Subject headings
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- Protein structure (and thus function) is dictated by non-covalent interaction networks. These can be highly evolutionarily conserved across protein families, the members of which can diverge in sequence and evolutionary history. Here we present KIN, a tool to identify and analyze conserved non-covalent interaction networks across evolutionarily related groups of proteins. KIN is available for download under a GNU General Public License, version 2, from https://www.github.com/kamerlinlab/KIN. KIN can operate on experimentally determined structures, predicted structures, or molecular dynamics trajectories, providing insight into both conserved and missing interactions across evolutionarily related proteins. This provides useful insight both into protein evolution, as well as a tool that can be exploited for protein engineering efforts. As a showcase system, we demonstrate applications of this tool to understanding the evolutionary-relevant conserved interaction networks across the class A β-lactamases.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Keyword
- protein interaction networks
- class A beta-lactamases
- protein contact analysis
- protein engineering
Publication and Content Type
- ref (subject category)
- art (subject category)
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