Search: onr:"swepub:oai:DiVA.org:uu-526207" >
Tumor Predisposing ...
-
Stankowska, WiktoriaMed Univ Gdansk, Med Lab 3P, M Sklodowskiej Curie 3A, PL-80210 Gdansk, Poland.
(author)
Tumor Predisposing Post-Zygotic Chromosomal Alterations in Bladder Cancer-Insights from Histologically Normal Urothelium
- Article/chapterEnglish2024
Publisher, publication year, extent ...
-
MDPI,2024
-
electronicrdacarrier
Numbers
-
LIBRIS-ID:oai:DiVA.org:uu-526207
-
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-526207URI
-
https://doi.org/10.3390/cancers16050961DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Bladder urothelial carcinoma (BLCA) is the 10th most common cancer with a low survival rate and strong male bias. We studied the field cancerization in BLCA using multi-sample- and multi-tissue-per-patient protocol for sensitive detection of autosomal post-zygotic chromosomal alterations and loss of chromosome Y (LOY). We analysed 277 samples of histologically normal urothelium, 145 tumors and 63 blood samples from 52 males and 15 females, using the in-house adapted Mosaic Chromosomal Alterations (MoChA) pipeline. This approach allows identification of the early aberrations in urothelium from BLCA patients. Overall, 45% of patients exhibited at least one alteration in at least one normal urothelium sample. Recurrence analysis resulted in 16 hotspots composed of either gains and copy number neutral loss of heterozygosity (CN-LOH) or deletions and CN-LOH, encompassing well-known and new BLCA cancer driver genes. Conservative assessment of LOY showed 29%, 27% and 18% of LOY-cells in tumors, blood and normal urothelium, respectively. We provide a proof of principle that our approach can characterize the earliest alterations preconditioning normal urothelium to BLCA development. Frequent LOY in blood and urothelium-derived tissues suggest its involvement in BLCA.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Sarkisyan, DaniilUppsala universitet,Cancerprecisionsmedicin,Science for Life Laboratory, SciLifeLab(Swepub:uu)dansa302
(author)
-
Bruhn-Olszewska, BozenaUppsala universitet,Cancerprecisionsmedicin,Science for Life Laboratory, SciLifeLab(Swepub:uu)bozbr209
(author)
-
Duzowska, KatarzynaMed Univ Gdansk, Med Lab 3P, M Sklodowskiej Curie 3A, PL-80210 Gdansk, Poland.
(author)
-
Bienkowski, MichalMed Univ Gdansk, Dept Pathomorphol, M Sklodowskiej Curie 3A, PL-80210 Gdansk, Poland.
(author)
-
Jakalski, MarcinMed Univ Gdansk, Med Lab 3P, M Sklodowskiej Curie 3A, PL-80210 Gdansk, Poland.
(author)
-
Wojcik-Zalewska, MagdalenaMed Univ Gdansk, Med Lab 3P, M Sklodowskiej Curie 3A, PL-80210 Gdansk, Poland.
(author)
-
Davies, HannaUppsala universitet,Science for Life Laboratory, SciLifeLab,Cancerprecisionsmedicin(Swepub:uu)handa349
(author)
-
Drezek-Chyla, KingaMed Univ Gdansk, Med Lab 3P, M Sklodowskiej Curie 3A, PL-80210 Gdansk, Poland.
(author)
-
Peksa, RafalMed Univ Gdansk, Dept Pathomorphol, M Sklodowskiej Curie 3A, PL-80210 Gdansk, Poland.
(author)
-
Harazin-Lechowska, AgnieszkaMaria Sklodowska Curie Natl Res Inst Oncol, Dept Tumor Pathol, Inst Oncol, Garncarska 11, PL-31115 Krakow, Poland.
(author)
-
Ambicka, AleksandraMaria Sklodowska Curie Natl Res Inst Oncol, Dept Tumor Pathol, Inst Oncol, Garncarska 11, PL-31115 Krakow, Poland.
(author)
-
Przewoznik, MarcinMaria Sklodowska Curie Natl Res Inst Oncol, Dept Tumor Pathol, Inst Oncol, Garncarska 11, PL-31115 Krakow, Poland.
(author)
-
Adamczyk, AgnieszkaMaria Sklodowska Curie Natl Res Inst Oncol, Dept Tumor Pathol, Inst Oncol, Garncarska 11, PL-31115 Krakow, Poland.
(author)
-
Sasim, KarolSpecialist Hosp Koscierzyna, Clin Urol & Oncol Urol, Piechowskiego 36, PL-83400 Koscierzyna, Poland.
(author)
-
Makarewicz, WojciechSpecialist Hosp Koscierzyna, Clin Gen & Oncol Surg, Piechowskiego 36, PL-83400 Koscierzyna, Poland.
(author)
-
Matuszewski, MarcinMed Univ Gdansk, Dept Clin Urol, M Sklodowskiej Curie 3A, PL-80210 Gdansk, Poland.
(author)
-
Biernat, WojciechMed Univ Gdansk, Dept Pathomorphol, M Sklodowskiej Curie 3A, PL-80210 Gdansk, Poland.
(author)
-
Järhult, Josef D.,1975-Uppsala universitet,Infektionsmedicin(Swepub:uu)josja939
(author)
-
Lipcsey, MiklósUppsala universitet,Hedenstiernalaboratoriet(Swepub:uu)milip123
(author)
-
Hultström, Michael,1978-Uppsala universitet,Integrativ Fysiologi,Anestesiologi och intensivvård(Swepub:uu)mihul498
(author)
-
Frithiof, RobertUppsala universitet,Anestesiologi och intensivvård(Swepub:uu)robfr118
(author)
-
Jaszczynski, JanuszMaria Sklodowska Curie Natl Res Inst Oncol, Dept Urol, Garncarska 11, PL-31115 Krakow, Poland.
(author)
-
Rys, JanuszMaria Sklodowska Curie Natl Res Inst Oncol, Dept Tumor Pathol, Inst Oncol, Garncarska 11, PL-31115 Krakow, Poland.
(author)
-
Genovese, GiulioHarvard Med Sch, Dept Genet, 77 Ave Louis Pasteur, Boston, MA 02115 USA.
(author)
-
Piotrowski, ArkadiuszMed Univ Gdansk, Med Lab 3P, M Sklodowskiej Curie 3A, PL-80210 Gdansk, Poland.;Med Univ Gdansk, Dept Biol & Pharmaceut Bot, Hallera 107, PL-80416 Gdansk, Poland.
(author)
-
Filipowicz, NataliaMed Univ Gdansk, Med Lab 3P, M Sklodowskiej Curie 3A, PL-80210 Gdansk, Poland.
(author)
-
Dumanski, Jan P.Uppsala universitet,Science for Life Laboratory, SciLifeLab,Cancerprecisionsmedicin,3P-Medicine Laboratory, Medical University of Gdańsk, M. Sklodowskiej-Curie 3A, 80-210 Gdańsk, Poland; Department of Biology and Pharmaceutical Botany, Medical University of Gdańsk, Hallera 107, 80-416 Gdańsk, Poland(Swepub:uu)janduman
(author)
-
Med Univ Gdansk, Med Lab 3P, M Sklodowskiej Curie 3A, PL-80210 Gdansk, Poland.Cancerprecisionsmedicin
(creator_code:org_t)
Related titles
-
In:Cancers: MDPI16:52072-6694
Internet link
Find in a library
-
Cancers
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
-
Stankowska, Wikt ...
-
Sarkisyan, Danii ...
-
Bruhn-Olszewska, ...
-
Duzowska, Katarz ...
-
Bienkowski, Mich ...
-
Jakalski, Marcin
-
show more...
-
Wojcik-Zalewska, ...
-
Davies, Hanna
-
Drezek-Chyla, Ki ...
-
Peksa, Rafal
-
Harazin-Lechowsk ...
-
Ambicka, Aleksan ...
-
Przewoznik, Marc ...
-
Adamczyk, Agnies ...
-
Sasim, Karol
-
Makarewicz, Wojc ...
-
Matuszewski, Mar ...
-
Biernat, Wojciec ...
-
Järhult, Josef D ...
-
Lipcsey, Miklós
-
Hultström, Micha ...
-
Frithiof, Robert
-
Jaszczynski, Jan ...
-
Rys, Janusz
-
Genovese, Giulio
-
Piotrowski, Arka ...
-
Filipowicz, Nata ...
-
Dumanski, Jan P.
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cancer and Oncol ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Medical Genetics
- Articles in the publication
-
Cancers
- By the university
-
Uppsala University