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Impairments in comp...
Impairments in complement receptor-and Fc receptor-mediated functions in vivo in patients with psoriasis
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- Nilsson-Ekdahl, Kristina (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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- Michaelsson, Gerd (author)
- Uppsala universitet,Dermatologi och venereologi,Dermatology and Venereology
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- Gerdén, Barbro (author)
- Uppsala universitet,Dermatologi och venereologi
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- Lööf, Lars (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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Nilsson, Bo (author)
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(creator_code:org_t)
- 1995
- 1995
- English.
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In: Archives of Dermatological Research. - 0340-3696 .- 1432-069X. ; 287:3-4, s. 225-230
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- The function of the fixed macrophage system in 18 psoriasis patients was evaluated by measuring the elimination rate of injected autologous erythrocytes coated with iC3b or IgG. The mean half-life of iC3b-coated erythrocytes was significantly prolonged in patients with psoriasis compared with healthy controls (4.7 +/- 0.8 vs 2.7 +/- 0.2 min, P = 0.01). There was also a decrease in the total number of cells eliminated from the circulation (2.5 +/- 0.2 x 10(8) vs 3.3 +/- 0.2 x 10(8), P = 0.01). There was an even more pronounced increase in the half-life of IgG-coated erythrocytes (85 +/- 18 vs 20 +/- 5 min, P < 0.001), with normal values in only 5 of 15 patients, and 4 of these 5 patients were receiving systemic treatment. The slow elimination was interpreted as being caused by primary or secondary defects in receptor function rather than by blocking of the receptors by immune complexes, since patients with psoriasis show normal levels of circulating immune complexes. Further studies are needed to elucidate the nature of these defects.
Keyword
- Complement receptors
- Erythrocytes
- Fc Receptors
- Immune complex
- Psoriasis
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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