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Impairments in comp...
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Nilsson-Ekdahl, KristinaUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
(author)
Impairments in complement receptor-and Fc receptor-mediated functions in vivo in patients with psoriasis
- Article/chapterEnglish1995
Publisher, publication year, extent ...
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-52632
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-52632URI
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https://doi.org/10.1007/BF01105070DOI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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The function of the fixed macrophage system in 18 psoriasis patients was evaluated by measuring the elimination rate of injected autologous erythrocytes coated with iC3b or IgG. The mean half-life of iC3b-coated erythrocytes was significantly prolonged in patients with psoriasis compared with healthy controls (4.7 +/- 0.8 vs 2.7 +/- 0.2 min, P = 0.01). There was also a decrease in the total number of cells eliminated from the circulation (2.5 +/- 0.2 x 10(8) vs 3.3 +/- 0.2 x 10(8), P = 0.01). There was an even more pronounced increase in the half-life of IgG-coated erythrocytes (85 +/- 18 vs 20 +/- 5 min, P < 0.001), with normal values in only 5 of 15 patients, and 4 of these 5 patients were receiving systemic treatment. The slow elimination was interpreted as being caused by primary or secondary defects in receptor function rather than by blocking of the receptors by immune complexes, since patients with psoriasis show normal levels of circulating immune complexes. Further studies are needed to elucidate the nature of these defects.
Subject headings and genre
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Complement receptors
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Erythrocytes
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Fc Receptors
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Immune complex
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Psoriasis
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MEDICINE
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MEDICIN
Added entries (persons, corporate bodies, meetings, titles ...)
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Michaelsson, GerdUppsala universitet,Dermatologi och venereologi,Dermatology and Venereology
(author)
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Gerdén, BarbroUppsala universitet,Dermatologi och venereologi
(author)
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Lööf, LarsUppsala universitet,Institutionen för medicinska vetenskaper
(author)
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Nilsson, Bo
(author)
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Uppsala universitetInstitutionen för medicinsk biokemi och mikrobiologi
(creator_code:org_t)
Related titles
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In:Archives of Dermatological Research287:3-4, s. 225-2300340-36961432-069X
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