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Cryo-EM of Aβ fibri...
Cryo-EM of Aβ fibrils from mouse models find tg-APPArcSwe fibrils resemble those found in patients with sporadic Alzheimer's disease
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Zielinski, Mara (author)
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Peralta Reyes, Fernanda S (author)
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Gremer, Lothar (author)
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Schemmert, Sarah (author)
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Frieg, Benedikt (author)
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Schäfer, Luisa U (author)
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Willuweit, Antje (author)
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Donner, Lili (author)
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Elvers, Margitta (author)
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Nilsson, Lars N G (author)
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- Syvänen, Stina (author)
- Uppsala universitet,Molekylär geriatrik,Molecular Geriatrics
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- Sehlin, Dag, 1976- (author)
- Uppsala universitet,Molekylär geriatrik,Molecular Geriatrics
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- Ingelsson, Martin (author)
- Uppsala universitet,Molekylär geriatrik
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Willbold, Dieter (author)
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Schröder, Gunnar F (author)
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(creator_code:org_t)
- Springer Nature, 2023
- 2023
- English.
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In: Nature Neuroscience. - : Springer Nature. - 1097-6256 .- 1546-1726. ; 26:12, s. 2073-2080
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https://uu.diva-port... (primary) (Raw object)
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Abstract
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- The use of transgenic mice displaying amyloid-β (Aβ) brain pathology has been essential for the preclinical assessment of new treatment strategies for Alzheimer's disease. However, the properties of Aβ in such mice have not been systematically compared to Aβ in the brains of patients with Alzheimer's disease. Here, we determined the structures of nine ex vivo Aβ fibrils from six different mouse models by cryogenic-electron microscopy. We found novel Aβ fibril structures in the APP/PS1, ARTE10 and tg-SwDI models, whereas the human type II filament fold was found in the ARTE10, tg-APPSwe and APP23 models. The tg-APPArcSwe mice showed an Aβ fibril whose structure resembles the human type I filament found in patients with sporadic Alzheimer's disease. A detailed assessment of the Aβ fibril structure is key to the selection of adequate mouse models for the preclinical development of novel plaque-targeting therapeutics and positron emission tomography imaging tracers in Alzheimer's disease.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Zielinski, Mara
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Peralta Reyes, F ...
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Gremer, Lothar
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Schemmert, Sarah
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Frieg, Benedikt
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Schäfer, Luisa U
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show more...
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Willuweit, Antje
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Donner, Lili
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Elvers, Margitta
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Nilsson, Lars N ...
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Syvänen, Stina
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Sehlin, Dag, 197 ...
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Ingelsson, Marti ...
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Willbold, Dieter
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Schröder, Gunnar ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Nature Neuroscie ...
- By the university
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Uppsala University