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Neutralizing IFN-γ ...
Neutralizing IFN-γ autoantibodies are rare and pathogenic in HLA-DRB1*15:02 or 16:02 individuals
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Peel, Jessica N. (author)
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Yang, Rui (author)
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Le Voyer, Tom (author)
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show more...
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Gervais, Adrian (author)
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Rosain, Jérémie (author)
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Bastard, Paul (author)
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- Behere, Anish, 1993- (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab
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- Cederholm, Axel (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för medicinsk biokemi och mikrobiologi
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Bodansky, Aaron (author)
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Seeleuthner, Yoann (author)
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Conil, Clément (author)
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Ding, Jing-Ya (author)
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Lei, Wei-Te (author)
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Bizien, Lucy (author)
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Soudee, Camille (author)
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Migaud, Mélanie (author)
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Ogishi, Masato (author)
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Yatim, Ahmad (author)
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Lee, Danyel (author)
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Bohlen, Jonathan (author)
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Perpoint, Thomas (author)
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Perez, Laura (author)
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Messina, Fernando (author)
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Genet, Roxana (author)
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Karkowski, Ludovic (author)
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Blot, Mathieu (author)
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Lafont, Emmanuel (author)
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Toullec, Laurie (author)
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Goulvestre, Claire (author)
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Mehlal-Sedkaoui, Souad (author)
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Sallette, Jérôme (author)
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Martin, Fernando (author)
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Puel, Anne (author)
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Jouanguy, Emmanuelle (author)
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Anderson, Mark S. (author)
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- Landegren, Nils, 1986- (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för medicinsk biokemi och mikrobiologi
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Tiberghien, Pierre (author)
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Abel, Laurent (author)
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Boisson-Dupuis, Stéphanie (author)
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Bustamante, Jacinta (author)
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Ku, Cheng-Lung (author)
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Casanova, Jean-Laurent (author)
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(creator_code:org_t)
- American Society For Clinical Investigation, 2024
- 2024
- English.
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In: Journal of Clinical Investigation. - : American Society For Clinical Investigation. - 0021-9738 .- 1558-8238. ; 134:8
- Related links:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- BACKGROUND. Weakly virulent environmental mycobacteria (EM) can cause severe disease in HLA-DRB1*15:02 or 16:02 adults harboring neutralizing anti-IFN-γ autoantibodies (nAIGAs). The overall prevalence of nAIGAs in the general population is unknown, as are the penetrance of nAIGAs in HLA-DRB1*15:02 or 16:02 individuals and the proportion of patients with unexplained, adult-onset EM infections carrying nAIGAs.METHODS. This study analyzed the detection and neutralization of anti-IFN-γ autoantibodies (auto-Abs) from 8,430 healthy individuals of the general population, 257 HLA-DRB1*15:02 or 16:02 carriers, 1,063 patients with autoimmune disease, and 497 patients with unexplained severe disease due to EM.RESULTS. We found that anti-IFN-γ auto-Abs detected in 4,148 of 8,430 healthy individuals (49.2%) from the general population of an unknown HLA-DRB1 genotype were not neutralizing. Moreover, we did not find nAIGAs in 257 individuals carrying HLA-DRB1* 15:02 or 16:02. Additionally, nAIGAs were absent in 1,063 patients with an autoimmune disease. Finally, 7 of 497 patients (1.4%) with unexplained severe disease due to EM harbored nAIGAs.CONCLUSION. These findings suggest that nAIGAs are isolated and that their penetrance in HLA-DRB1*15:02 or 16:02 individuals is low, implying that they may be triggered by rare germline or somatic variants. In contrast, the risk of mycobacterial disease in patients with nAIGAs is high, confirming that these nAIGAs are the cause of EM disease.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Peel, Jessica N.
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Yang, Rui
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Le Voyer, Tom
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Gervais, Adrian
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Rosain, Jérémie
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Bastard, Paul
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show more...
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Behere, Anish, 1 ...
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Cederholm, Axel
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Bodansky, Aaron
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Seeleuthner, Yoa ...
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Conil, Clément
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Ding, Jing-Ya
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Lei, Wei-Te
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Bizien, Lucy
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Soudee, Camille
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Migaud, Mélanie
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Ogishi, Masato
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Yatim, Ahmad
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Lee, Danyel
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Bohlen, Jonathan
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Perpoint, Thomas
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Perez, Laura
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Messina, Fernand ...
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Genet, Roxana
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Karkowski, Ludov ...
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Blot, Mathieu
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Lafont, Emmanuel
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Toullec, Laurie
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Goulvestre, Clai ...
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Mehlal-Sedkaoui, ...
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Sallette, Jérôme
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Martin, Fernando
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Puel, Anne
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Jouanguy, Emmanu ...
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Anderson, Mark S ...
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Landegren, Nils, ...
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Tiberghien, Pier ...
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Abel, Laurent
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Boisson-Dupuis, ...
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Bustamante, Jaci ...
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Ku, Cheng-Lung
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Casanova, Jean-L ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
- Articles in the publication
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Journal of Clini ...
- By the university
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Uppsala University