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Platelet-derived gr...
Platelet-derived growth factor beta receptor regulates interstitial fluid homeostasis through phosphatidylinositol-3' kinase signaling
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- Heuchel, Rainer (author)
- Ludwiginstitutet för Cancerforskning
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Berg, Ansgar (author)
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Tallquist, Michelle (author)
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- Åhlén, Karina (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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Reed, Rolf K (author)
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- Rubin, Kristofer (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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- Claesson-Welsh, Lena (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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- Heldin, Carl-Henrik (author)
- Ludwiginstitutet för Cancerforskning
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Soriano, Philippe (author)
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(creator_code:org_t)
- 1999
- 1999
- English.
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In: Proc Natl Acad Sci U S A. ; 96:20, s. 11410-5
- Related links:
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https://urn.kb.se/re...
Abstract
Subject headings
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- Platelet-derived growth factor (PDGF) isoforms lead to mitogenic, survival, and chemotactic responses in a variety of mesenchymal cell types during development and in the adult. We have studied the importance of phosphatidylinositol-3' kinase (PI3K) signaling in these responses by mutating the PI3K-binding sites in the PDGF-beta receptor by gene targeting in embryonic stem cells. Homozygous mutant mice developed normally; however, cells derived from the mutants were less chemotactic and had largely lost their ability to contract collagen gels in response to PDGF. Injection of a mast cell degranulating agent in mice led to a decrease in interstitial fluid pressure resulting in edema formation. In contrast to wild-type mice, mutant mice were unable to normalize the pressure after treatment with PDGF. Taken together, these observations suggest a function for PDGF signaling through PI3K in interstitial fluid homeostasis by modulating the tension between cells and extracellular matrix structures.
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- art (subject category)
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