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STING inhibitors sensitize platinum chemotherapy in ovarian cancer by inhibiting the CGAS-STING pathway in cancer-associated fibroblasts (CAFs)
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- Liu, Jiale (author)
- Shandong Univ, Qilu Hosp, Dept Obstet & Gynecol, 107 Wenhua Xi Rd, Jinan 250012, Shandong, Peoples R China.
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- Liu, Chenmian (author)
- Shandong Univ, Qilu Hosp, Dept Obstet & Gynecol, 107 Wenhua Xi Rd, Jinan 250012, Shandong, Peoples R China.
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- Ma, Yana (author)
- Shandong Univ, Qilu Hosp, Dept Obstet & Gynecol, 107 Wenhua Xi Rd, Jinan 250012, Shandong, Peoples R China.
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- Shandong Univ, Qilu Hosp, Dept Obstet & Gynecol, 107 Wenhua Xi Rd, Jinan 250012, Shandong, Peoples R China Shandong First Med Univ, Shandong Prov Hosp, Dept Obstet & Gynecol, Jinan 250021, Shandong, Peoples R China. (creator_code:org_t)
- Elsevier, 2024
- 2024
- English.
- In: Cancer Letters. - : Elsevier. - 0304-3835 .- 1872-7980. ; 588
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Chemotherapy resistance in ovarian cancer hampers cure rates, with cancer-associated fibroblasts (CAFs) playing a pivotal role. Despite their known impact on cancer progression and chemotherapy resistance, the specific mechanism by which CAFs regulate the tumor inflammatory environment remains unclear. This study reveals that cisplatin facilitates DNA transfer from ovarian cancer cells to CAFs, activating the CGAS-STING-IFNB1 pathway in CAFs and promoting IFNB1 release. Consequently, this reinforces cancer cell resistance to platinum drugs. High STING expression in the tumor stroma was associated with a poor prognosis, while inhibiting STING expression enhanced ovarian cancer sensitivity. Understanding the relevance of the CGAS-STING pathway in CAFs for platinum resistance suggests targeting STING as a promising combination therapy for ovarian cancer, providing potential avenues for improved treatment outcomes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Ovarian cancer
- Chemoresistance
- Cancer -associated fibroblasts
- STING inhibitors
- IFNB1
Publication and Content Type
- ref (subject category)
- art (subject category)
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- Liu, Jiale
- Liu, Chenmian
- Ma, Yana
- Pan, Xiyu
- Chu, Ran
- Yao, Shu
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- Chen, Junyu
- Liu, Chang
- Chen, Zhongshao
- Sheng, Chenchen
- Zhang, Kai
- Xue, Ying
- Schiöth, Helgi
- Kong, Beihua
- Zhang, Qing
- Song, Kun
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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- Cancer Letters
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- Uppsala University
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