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Studies in children...
Studies in children with obesity in two European treatment centres show a high prevalence of impaired glucose metabolism in the Swedish cohort
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- Ciba, Iris (author)
- Uppsala universitet,Pediatrisk inflammations- och metabolismforskning samt barnhälsa,Uppsala Univ, Childrens Hosp, Uppsala, Sweden.
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- Dahlbom, Marie (author)
- Uppsala universitet,Pediatrisk inflammations- och metabolismforskning samt barnhälsa,Uppsala Univ, Childrens Hosp, Uppsala, Sweden.
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- Manell, Hannes (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi,Uppsala Univ, Childrens Hosp, Uppsala, Sweden.
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- Mörwald, Katharina (author)
- Paracelsus Med Univ, Dept Pediat, Salzburg, Austria.;Paracelsus Med Univ, Obes Res Unit, Salzburg, Austria.
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- Roomp, Kirsten (author)
- Univ Luxembourg, Luxembourg Ctr Syst Biomed, Belvaux, Luxembourg.
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- Weghuber, Daniel (author)
- Paracelsus Med Univ, Dept Pediat, Salzburg, Austria.;Paracelsus Med Univ, Obes Res Unit, Salzburg, Austria.
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- Bergsten, Peter (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi,Pediatrisk inflammations- och metabolismforskning samt barnhälsa,Uppsala Univ, Childrens Hosp, Uppsala, Sweden.
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- Forslund, Anders, 1961- (author)
- Uppsala universitet,Pediatrisk inflammations- och metabolismforskning samt barnhälsa,Uppsala Univ, Childrens Hosp, Uppsala, Sweden.
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(creator_code:org_t)
- John Wiley & Sons, 2024
- 2024
- English.
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In: Acta Paediatrica. - : John Wiley & Sons. - 0803-5253 .- 1651-2227. ; 113:2, s. 286-295
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Abstract
Subject headings
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- Aim: To investigate the prevalence and possible risk factors for the development of impaired glucose metabolism in children and adolescents with obesity.Methods: This was a cross-sectional retrospective cohort study, including 634 patients with obesity and 98 normal weight controls aged 4-18 years from the Beta-cell function in Juvenile Diabetes and Obesity (Beta-JUDO) cohort, a dual-centre study at Uppsala University Hospital (Sweden) and Paracelsus Medical University Hospital (Salzburg, Austria) conducted between 2012 and 2021. A longitudinal subgroup analysis, including 188 of these subjects was performed. Impaired glucose metabolism was diagnosed by oral glucose tolerance tests according to American Diabetes Association criteria.Results: The prevalence of impaired glucose metabolism was 72% in Uppsala patients, 24% in Salzburg patients, 30% in Uppsala controls and 13% in Salzburg controls. The prevalence was lower at the follow-up visits compared with baseline both in Uppsala and Salzburg patients. A family history of type 2 diabetes showed the strongest association with impaired glucose metabolism at the follow-up visits besides belonging to the Uppsala cohort.Conclusion: The prevalence of impaired glucose metabolism was extraordinarily high in Swedish children and adolescents with obesity, but decreased during the follow-up period.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- Austria
- glucose metabolism
- Paediatric obesity
- Sweden
- type 2 diabetes
Publication and Content Type
- ref (subject category)
- art (subject category)
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