Expression of intestinal drug transporter proteins and metabolic enzymes in neonatal and pediatric patients

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: onr:"swepub:oai:DiVA.org:uu-528223" > Expression of intes...

1 of 1
Previous record
Next record
To hitlist

Details
MARC

de Waal, TomKatholieke Univ Leuven, Drug Delivery & Disposit, Leuven, Belgium. (author)

Expression of intestinal drug transporter proteins and metabolic enzymes in neonatal and pediatric patients

Article/chapterEnglish2024

Publisher, publication year, extent ...

Elsevier,2024
printrdacarrier

Numbers

LIBRIS-ID:oai:DiVA.org:uu-528223
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-528223URI
https://doi.org/10.1016/j.ijpharm.2024.123962DOI

Supplementary language notes

Language:English
Summary in:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

The development of pediatric oral drugs is hampered by a lack of predictive simulation tools. These tools, in turn, require data on the physiological variables that influence oral drug absorption, including the expression of drug transporter proteins (DTPs) and drug-metabolizing enzymes (DMEs) in the intestinal tract. The expression of hepatic DTPs and DMEs shows age-related changes, but there are few data on protein levels in the intestine of children. In this study, tissue was collected from different regions of the small and large intestine from neonates (i.e., surgically removed tissue) and from pediatric patients (i.e., gastroscopic duodenal biopsies). The protein expression of clinically relevant DTPs and DMEs was determined using a targeted mass spectrometry approach. The regional distribution of DTPs and DMEs was similar to adults. Most DTPs, with the exception of MRP3, MCT1, and OCT3, and all DMEs showed the highest protein expression in the proximal small intestine. Several proteins (i.e., P-gp, ASBT, CYP3A4, CYP3A5, CYP2C9, CYP2C19, and UGT1A1) showed an increase with age. Such increase appeared to be even more pronounced for DMEs. This exploratory study highlights the developmental changes in DTPs and DMEs in the intestinal tract of the pediatric population. Additional evaluation of protein function in this population would elucidate the implications of the presented changes in protein expression on absorption of orally administered drugs in neonates and pediatric patients.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Farmaceutiska vetenskaper hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Pharmaceutical Sciences hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Pediatrik hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Pediatrics hsv//eng
Drug transporter proteins
Metabolic enzymes
Pediatric patients
Neonates
Gastrointestinal ontogeny

Added entries (persons, corporate bodies, meetings, titles ...)

Handin, NiklasUppsala universitet,Institutionen för farmaci(Swepub:uu)nikha230 (author)
Brouwers, JoachimKatholieke Univ Leuven, Drug Delivery & Disposit, Leuven, Belgium. (author)
Miserez, MarcUniv Hosp Leuven, Dept Abdominal Surg, Leuven, Belgium. (author)
Hoffman, IlseUniv Hosp Leuven, Pediat Gastroenterol Hepatol & Nutr, Leuven, Belgium. (author)
Rayyan, MaissaUniv Hosp Leuven, Neonatal Intens Care Unit, Leuven, Belgium. (author)
Artursson, PerUppsala universitet,Institutionen för farmaci(Swepub:uu)perartur (author)
Augustijns, PatrickKatholieke Univ Leuven, Drug Delivery & Disposit, Leuven, Belgium. (author)
Katholieke Univ Leuven, Drug Delivery & Disposit, Leuven, Belgium.Institutionen för farmaci (creator_code:org_t)

Related titles

In:International Journal of Pharmaceutics: Elsevier6540378-51731873-3476

Internet link

Find in a library

International Journal of Pharmaceutics (Search for host publication in LIBRIS)

To the university's database

1 of 1
Previous record
Next record
To hitlist

Find more in SwePub

By the author/editor: de Waal, Tom; Handin, Niklas; Brouwers, Joachi ...; Miserez, Marc; Hoffman, Ilse; Rayyan, Maissa; show more...; Artursson, Per; Augustijns, Patr ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Pharmaceutical S ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Pediatrics

Articles in the publication: International Jo ...

By the university: Uppsala University

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se