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Sustained IFN signa...
Sustained IFN signaling is associated with delayed development of SARS-CoV-2-specific immunity.
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- Brunet-Ratnasingham, Elsa (author)
- Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.
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- Morin, Sacha (author)
- Department of Computer Science and Operations Research, Université de Montréal, Montreal, QC, Canada.
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- Randolph, Haley E (author)
- Committee on Genetics, Genomics, and Systems Biology, University of Chicago, Chicago, IL, USA.
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- Labrecque, Marjorie (author)
- Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.
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- Bélair, Justin (author)
- Department of Mathematics and Statistics, Université de Montréal, Montreal, QC, Canada.
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- Lima-Barbosa, Raphaël (author)
- Department of Mathematics and Statistics, Université de Montréal, Montreal, QC, Canada.
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- Pagliuzza, Amélie (author)
- Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.
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- Marchitto, Lorie (author)
- Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.
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- Hultström, Michael (author)
- Uppsala universitet,Anestesiologi och intensivvård
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- Niessl, Julia (author)
- Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.
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- Cloutier, Rose (author)
- Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.
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- Sreng Flores, Alina M (author)
- Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.
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- Brassard, Nathalie (author)
- Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.
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- Benlarbi, Mehdi (author)
- Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.
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- Prévost, Jérémie (author)
- Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.
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- Ding, Shilei (author)
- Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.
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- Anand, Sai Priya (author)
- Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.
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- Sannier, Gérémy (author)
- Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.
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- Marks, Amanda (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
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- Wågsäter, Dick (author)
- Uppsala universitet,Integrativ Fysiologi
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- Bareke, Eric (author)
- Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.
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- Zeberg, Hugo (author)
- Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
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- Lipcsey, Miklos (author)
- Uppsala universitet,Anestesiologi och intensivvård
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- Frithiof, Robert (author)
- Uppsala universitet,Anestesiologi och intensivvård
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- Larsson, Anders (author)
- Uppsala universitet,Klinisk kemi
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- Zhou, Sirui (author)
- Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada.
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- Nakanishi, Tomoko (author)
- Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada.
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- Morrison, David (author)
- Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada.
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- Vezina, Dani (author)
- Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.
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- Bourassa, Catherine (author)
- Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.
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- Gendron-Lepage, Gabrielle (author)
- Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.
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- Medjahed, Halima (author)
- Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.
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- Point, Floriane (author)
- Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.
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- Richard, Jonathan (author)
- Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.
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- Larochelle, Catherine (author)
- Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.
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- Prat, Alexandre (author)
- Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.
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- Cunningham, Janet L (author)
- Uppsala universitet,Psykiatri
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- Arbour, Nathalie (author)
- Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.
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- Durand, Madeleine (author)
- Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.
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- Richards, J Brent (author)
- Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada.
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- Moon, Kevin (author)
- Department of Mathematics and Statistics, Utah State University, Logan, UT, USA.
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- Chomont, Nicolas (author)
- Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.
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- Finzi, Andrés (author)
- Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.
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- Tétreault, Martine (author)
- Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.
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- Barreiro, Luis (author)
- Committee on Genetics, Genomics, and Systems Biology, University of Chicago, Chicago, IL, USA.
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- Wolf, Guy (author)
- Department of Computer Science and Operations Research, Université de Montréal, Montreal, QC, Canada. guy.wolf@umontreal.ca.
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- Kaufmann, Daniel E (author)
- Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada. daniel.kaufmann@chuv.ch.
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Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada Department of Computer Science and Operations Research, Université de Montréal, Montreal, QC, Canada. (creator_code:org_t)
- 2024
- 2024
- English.
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In: Nature Communications. - 2041-1723. ; 15:1, s. 4177-
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Plasma RNAemia, delayed antibody responses and inflammation predict COVID-19 outcomes, but the mechanisms underlying these immunovirological patterns are poorly understood. We profile 782 longitudinal plasma samples from 318 hospitalized patients with COVID-19. Integrated analysis using k-means reveals four patient clusters in a discovery cohort: mechanically ventilated critically-ill cases are subdivided into good prognosis and high-fatality clusters (reproduced in a validation cohort), while non-critical survivors segregate into high and low early antibody responders. Only the high-fatality cluster is enriched for transcriptomic signatures associated with COVID-19 severity, and each cluster has distinct RBD-specific antibody elicitation kinetics. Both critical and non-critical clusters with delayed antibody responses exhibit sustained IFN signatures, which negatively correlate with contemporaneous RBD-specific IgG levels and absolute SARS-CoV-2-specific B and CD4+ T cell frequencies. These data suggest that the "Interferon paradox" previously described in murine LCMV models is operative in COVID-19, with excessive IFN signaling delaying development of adaptive virus-specific immunity.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Brunet-Ratnasing ...
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Morin, Sacha
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Randolph, Haley ...
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Labrecque, Marjo ...
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Bélair, Justin
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Lima-Barbosa, Ra ...
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show more...
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Pagliuzza, Améli ...
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Marchitto, Lorie
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Hultström, Micha ...
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Niessl, Julia
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Cloutier, Rose
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Sreng Flores, Al ...
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Brassard, Nathal ...
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Benlarbi, Mehdi
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Prévost, Jérémie
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Ding, Shilei
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Anand, Sai Priya
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Sannier, Gérémy
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Marks, Amanda
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Wågsäter, Dick
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Bareke, Eric
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Zeberg, Hugo
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Lipcsey, Miklos
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Frithiof, Robert
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Larsson, Anders
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Zhou, Sirui
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Nakanishi, Tomok ...
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Morrison, David
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Vezina, Dani
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Bourassa, Cather ...
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Gendron-Lepage, ...
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Medjahed, Halima
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Point, Floriane
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Richard, Jonatha ...
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Larochelle, Cath ...
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Prat, Alexandre
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Cunningham, Jane ...
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Arbour, Nathalie
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Durand, Madelein ...
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Richards, J Bren ...
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Moon, Kevin
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Chomont, Nicolas
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Finzi, Andrés
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Tétreault, Marti ...
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Barreiro, Luis
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Wolf, Guy
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Kaufmann, Daniel ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Anesthesiology a ...
- Articles in the publication
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Nature Communica ...
- By the university
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Uppsala University