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Exhaled Nitric Oxid...
Exhaled Nitric Oxide Reflects the Immune Reactions of the Airways in Early Rheumatoid Arthritis
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- Weitoft, Tomas (author)
- Uppsala universitet,Centrum för klinisk forskning, Gävleborg,Reumatologi,Uppsala Univ, Sweden
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- Rönnelid, Johan (author)
- Uppsala universitet,Vaskulärbiologi,Uppsala Univ, Sweden
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- Lind, Anders (author)
- Uppsala universitet,Centrum för klinisk forskning, Gävleborg,Uppsala Univ, Sweden
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- de Vries, Charlotte (author)
- Rheumatology Unit, Department of Medicine, Karolinska University Hospital, 171 76 Solna, Sweden,Karolinska Univ Hosp, Sweden
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- Larsson, Anders (author)
- Uppsala universitet,Klinisk kemi,Uppsala Univ, Sweden
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- Potempa, Barbara (author)
- Department of Oral Immunity and Infectious Diseases, School of Dentistry, University of Louisville, 501 S. Preston St., Louisville, KY 40202, USA,Univ Louisville, KY 40202 USA
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- Potempa, Jan (author)
- Department of Oral Immunity and Infectious Diseases, School of Dentistry, University of Louisville, 501 S. Preston St., Louisville, KY 40202, USA;Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa St. 7, 31-387 Krakow, Poland,Univ Louisville, KY 40202 USA; Jagiellonian Univ, Poland
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- Kastbom, Alf (author)
- Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland
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- Martinsson, Klara (author)
- Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten
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- Lundberg, Karin (author)
- Rheumatology Unit, Department of Medicine, Karolinska University Hospital, 171 76 Solna, Sweden,Karolinska Univ Hosp, Sweden
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- Högman, Marieann (author)
- Uppsala universitet,Lung- allergi- och sömnforskning,Uppsala Univ, Sweden
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(creator_code:org_t)
- MDPI, 2024
- 2024
- English.
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In: Biomedicines. - : MDPI. - 2227-9059. ; 12:5
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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Abstract
Subject headings
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- Patients with rheumatoid arthritis (RA) have altered levels of exhaled nitric oxide (NO) compared with healthy controls. Here, we investigated whether the clinical features of and immunological factors in RA pathogenesis could be linked to the NO lung dynamics in early disease. A total of 44 patients with early RA and anti-citrullinated peptide antibodies (ACPAs), specified as cyclic citrullinated peptide 2 (CCP2), were included. Their exhaled NO levels were measured, and the alveolar concentration, the airway compartment diffusing capacity and the airway wall concentration of NO were estimated using the Högman–Meriläinen algorithm. The disease activity was measured using the Disease Activity Score for 28 joints. Serum samples were analysed for anti-CCP2, rheumatoid factor, free secretory component, secretory component containing ACPAs, antibodies against Porphyromonas gingivalis (Rgp) and total levels of IgA, IgA1 and IgA2. Significant negative correlations were found between the airway wall concentration of NO and the number of swollen joints (Rho −0.48, p = 0.004), between the airway wall concentration of NO and IgA rheumatoid factor (Rho −0.41, p = 0.017), between the alveolar concentration and free secretory component (Rho −0.35, p = 0.023) and between the alveolar concentration and C-reactive protein (Rho −0.36, p = 0.016), but none were found for anti-CCP2, IgM rheumatoid factor or the anti-Rgp levels. In conclusion, altered NO levels, particularly its production in the airway walls, may have a role in the pathogenesis of ACPA-positive RA.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- rheumatoid arthritis
- free secretory component
- ACPA
- exhaled nitric oxide
- lung
- pathogenesis
- rheumatoid factor
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Weitoft, Tomas
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Rönnelid, Johan
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Lind, Anders
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de Vries, Charlo ...
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Larsson, Anders
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Potempa, Barbara
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Potempa, Jan
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Kastbom, Alf
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Martinsson, Klar ...
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Lundberg, Karin
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Högman, Marieann
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Respiratory Medi ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
- Articles in the publication
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Biomedicines
- By the university
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Uppsala University
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Linköping University