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Compositional and f...
Compositional and functional differences of the vaginal microbiota of women with and without cervical dysplasia.
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- Norenhag, Johanna (author)
- Uppsala universitet,Reproduktionsbiologi
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- Edfeldt, Gabriella (author)
- Karolinska Institutet
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- Stålberg, Karin (author)
- Uppsala universitet,Reproduktiv hälsa
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Garcia, Fabricio (author)
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Hugerth, Luisa Warchavchik (author)
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Engstrand, Lars (author)
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- Fransson, Emma, PhD, 1973- (author)
- Karolinska Institutet,Uppsala universitet,Obstetrisk och reproduktiv hälsoforskning
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Du, Juan (author)
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Schuppe-Koistinen, Ina (author)
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- Olovsson, Matts, 1958- (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Reproduktionsbiologi
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(creator_code:org_t)
- 2024
- 2024
- English.
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In: Scientific Reports. - 2045-2322. ; 14:1, s. 11183-
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Alterations in the vaginal microbiota, including both species composition and functional pathways, have been associated with HPV infection and progression of dysplasia to cervical cancer. To further explore this, shotgun metagenomic sequencing was used to taxonomically and functionally characterize the vaginal microbiota of women with and without cervical dysplasia. Women with histologically verified dysplasia (n = 177; low grade dysplasia (LSIL) n = 81, high-grade dysplasia (HSIL) n = 94, cancer n = 2) were compared with healthy controls recruited from the cervical screening programme (n = 177). Women with dysplasia had a higher vaginal microbial diversity, and higher abundances of Gardnerella vaginalis, Aerococcus christensenii, Peptoniphilus lacrimalis and Fannyhessea vaginae, while healthy controls had higher relative abundance of Lactobacillus crispatus. Genes involved in e.g. nucleotide biosynthesis and peptidoglycan biosynthesis were more abundant in women with dysplasia. Healthy controls showed higher abundance of genes important for e.g. amino acid biosynthesis, (especially L-lysine) and sugar degradation. These findings suggest that the microbiota may have a role in creating a pro-oncogenic environment in women with dysplasia. Its role and potential interactions with other components in the microenvironment deserve further exploration.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Norenhag, Johann ...
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Edfeldt, Gabriel ...
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Stålberg, Karin
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Garcia, Fabricio
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Hugerth, Luisa W ...
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Engstrand, Lars
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Fransson, Emma, ...
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Du, Juan
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Schuppe-Koistine ...
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Olovsson, Matts, ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Obstetrics Gynae ...
- Articles in the publication
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Scientific Repor ...
- By the university
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Uppsala University
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Karolinska Institutet